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    Guided by the National HIV/AIDS Strategy for the United States, CDC provides national leadership and support for the implementation of a high-impact prevention approach to reducing new HIV infections by using combinations of scientifically proven, cost-effective, and scalable interventions and prevention strategies directed towards the most vulnerable populations in the US who are most affected by, or at greatest risk for, HIV infection. Find out more about the Division of HIV Prevention’s funded programs and interventions.

    Effective Interventions

    Interventions and strategies with evidence of effectiveness from the Compendium are used to support the Ending the HIV Epidemic in the U.S. initiative. The highest-impact HIV prevention, care, treatment, and outbreak response strategies are scaled up to provide the biggest impact.

    Compendium

    The Evidence-Based Interventions (EBIs) and Best Practices in the Compendium are identified by the CDC’s Prevention Research Synthesis (PRS) Project through a series of ongoing systematic reviews.

    Replicating Effective Programs (REP)

    The programs in REP are tested, science-based behavioral interventions with demonstrated evidence of effectiveness in reducing risky behaviors, such as unprotected sex, or in encouraging safer ones, such as using condoms and other methods of practicing safer sex.

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    Page last reviewed: March 2, 2022
    Content source: Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention
    homeIntervention Research
    • Effective Interventions
    • Prevention Research Synthesisplus icon
      • PRS FAQ
      • Systematic Reviews and Publicationsplus icon
        • Systematic Reviews FAQ
        • Systematic Reviews
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        • Search PRS Publications
        • Featured Publications
    • Compendium of Evidence-Based Interventions and Best Practices for HIV Preventionplus icon
      • PrEP Chapterplus icon
        • PrEP Best Practices Criteria
        • Complete List of PrEP Best Practices Interventions
      • Structural Interventions (SI) Chapterplus icon
        • SI Best Practices Criteria
        • Complete List of SI Best Practices
      • Linkage to, Retention in, and Re-engagement in HIV Care (LRC) Chapterplus icon
        • LRC Best Practices Criteria
        • Complete List of LRC Best Practices
      • Medication Adherence (MA) Chapterplus icon
        • MA Efficacy Criteria
        • Complete List of MA EBIs
      • Risk Reduction (RR) Chapterplus icon
        • RR Efficacy Criteria
        • Complete List of RR EBIs
        • RR Archived Interventions
      • Search the Compendium
      • Featured Interventions
    • Replicating Effective Programs (REP)plus icon
      • REP Packages

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