Strategies for Prevention and Response to Novel & Targeted Multidrug-Resistant Organisms (MDROs)


Multidrug-resistant organisms (MDROs) are continuing to develop and spread in healthcare settings throughout the United States. Because of this, efforts to prevent MDRO transmission are still needed. In the past, MDROs were identified after lab confirmation, however, research has found that these organisms can spread long before being detected. A prevention approach that incorporates multiple healthcare facilities can potentially limit spread more effectively than response strategies alone.

CDC has developed two guides and FAQs for healthcare facilities, state, local, and territorial health departments to limit the spread of novel or targeted (e.g., Candida auris, carbapenemase-producing CRE) MDROs, FAQs, and a graphic (Figure 1) showing the relationship between prevention and response activities.

Comparison of Strategies

Figure 1. Relationship between epidemic stages, response tiers, containment response, and prevention activities for novel or targeted MDROs.

Frequently Asked Questions

Evidence for Prevention Interventions

Facility Risk Stratification & Prevention Planning


Colonization Screening

Other Prevention Strategies

Response Implementation