Articles about Sickle Cell Disease

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Featured Topics on Sickle Cell Disease

Sickle Cell Data Collection Program
This World Sickle Cell Day 2023, learn about CDC’s SCDC program, and find a suite of online resources that can help you or someone you know live healthy with SCD.

Stories of Sickle Cell
Learn about sickle cell disease and the Stories of Sickle Cell project.

CDC Study Highlights Importance of Increasing Flu Vaccine for People with Sickle Cell Disease
Flu vaccination is particularly important for people who are at higher risk of serious complications from influenza. This includes people with SCD.

What is Sickle Cell Disease?
Learn about sickle cell disease and find resources for patients and caregivers.

Sickle Cell Summer Camp
Learn about Sickle Cell Camp and find one near you.

Did You Know Sickle Cell Has Many Faces?
Learn about the many faces of sickle cell disease and read Mimi’s story.

Sickle Cell Disease Monitoring
CDC is working to raise awareness about sickle cell disease. You can help by reading and sharing our resources with friends and family.

Taking Charge of Your Health and Health Care
Learn how young people with sickle cell disease can take a more active role in their health care.

Caregivers and Sickle Cell Disease
Learn the effect sickle cell disease has on family members & caregivers.

Recent Scientific Articles

* These CDC scientific articles are listed in order of date published from 2014 to present.

Use of Recommended Health Care Measures to Prevent Selected Complications of Sickle Cell Anemia in Children and Adolescents — Selected U.S. States, 2019
Schieve LA, Simmons GM, Payne AB, et al. MMWR Morb Mortal Wkly Rep 2022;71:1241–1246. DOI:

Surveillance for Sickle Cell Disease — Sickle Cell Data Collection Program, Two States, 2004–2018.
Snyder AB, Lakshmanan S, Hulihan MM, et al. MMWR Surveill Summ 2022;71(No. SS-9):1–18. DOI:

Prioritizing Sickle Cell Disease.
Lewis L. Hsu, W. Craig Hooper, Laura A. Schieve. Pediatrics December 2022; 150 (6): e2022059491. 10.1542/peds.2022-059491

Sickle Cell Disease: A Review
Kavanagh PL, Fasipe TA, Wun T. JAMA. 2022;328(1):57–68. doi:10.1001/jama.2022.10233

COVID-19 and Sickle Cell Disease-Related Deaths Reported in the United States.
Payne AB, Schieve LA, Abe K, Hulihan M, Hooper WC, Hsu LL. [published online ahead of print, 2022 Jan 21]. Public Health Rep. 2022;333549211063518. doi:10.1177/00333549211063518.

Influenza vaccination rates and hospitalizations among Medicaid enrollees with and without sickle cell disease, 2009-2015.
Payne AB, Adamkiewicz TV, Grosse SD, Steffens A, Shay DK, Reed C, Schieve LA. Pediatr Blood Cancer. 2021 Sep 20:e29351. doi: 10.1002/pbc.29351. Epub ahead of print. PMID: 34542932.

Coronavirus Disease Among Persons with Sickle Cell Disease, United States, March 20–May 21, 2020
Panepinto JA, Brandow A, Mucalo L, Yusuf F, Singh A, Taylor B, Payne AB, Peacock G, Schieve LA. Emerging Infectious Diseases. 2020 Oct. doi: 10.3201/eid2610.202792.

Trends in sickle cell disease-related mortality in the United States, 1979-2017
Payne AB, Mehal JM, Chapman C, Haberling DL, Richardson LC, Bean CJ, Hooper WC. Annals of Emergency Medicine. 2020; 76 (3S):S28-S36

Using surveillance to determine the number of individuals with sickle cell disease in California and Georgia, 2005-2016
Aluc A, Zhou M, Paulukonis ST, Snyder AB, Wong D, Hulihan MM. [published online ahead of print, 2020 Aug 12]. Pediatr Hematol Oncol. 2020;1-5. doi:10.1080/08880018.2020.1779886

Impact of Medicaid expansion on access and healthcare among individuals with sickle cell disease
Kayle M, Valle J, Paulukonis S, Holl JL, Tanabe P, French DD, Garg R, Liem RI, Badawy SM, Treadwell MJ. Pediatr Blood Cancer. 2020 May;67(5):e28152.

Acute Care Utilization at End of Life in Sickle Cell Disease: Highlighting the Need for a Palliative Approach
Johnston EE, Adesina OO, Alvarez E, Amato H, Paulukonis S, Nichols A, Chamberlain LJ, Bhatia S. J Palliat Med. 2020 Jan;23(1):24-32.

Characterizing complication risk from multisite, intermittent transfusions for the treatment of sickle cell disease
Tang A, Branscomb J, Zhou M, Snyder A, Eckman J. Pediatr Blood Cancer. 2019 Oct;66(10):e27921.

Health literacy and knowledge of chronic transfusion therapy in adolescents with sickle cell disease and caregivers
Yee MEM, Meyer EK, Fasano, RM, Lane PA, Josephson CD, Brega AG. Pediatr Blood Cancer. 2019 Jul;66(7):e27733.

Understanding the Complications of Sickle Cell Disease
Tanabe P, Spratling R, Smith D, Grissom P, Hulihan M.  American Journal of Nursing 2019 June; 119 (6) 26-35. doi: 10.1097/01.NAJ.0000559779.40570.2c

Improving an Administrative Case Definition for Longitudinal Surveillance of Sickle Cell Disease
Snyder AB, Zhou M, Theodore R, Quarmyne MO, Eckman J, Lane PA. Public Health Rep. 2019 May/Jun;134(3):274-281. doi: 10.1177/0033354919839072.

Transfusion service knowledge and immunohaematological practices related to sickle cell disease and thalassemia
Fasano RM, Branscomb J, Lane PA, Josephson CD, Snyder AB, Eckman JR. Transfus Med. 2019 Feb 10.

Facilitators and Barriers to Minority Blood Donations: A Systematic Review
Spratling R, Lawrence RH. Nurs Res. 2019 Mar 1. [Epub ahead of print].

A Strategic Planning Tool for Increasing African American Blood Donation
Singleton A, Spratling R. Health Promot Pract. 2018 May 1:1524839918775733. doi: 10.1177/1524839918775733.

Hemoglobin A clearance in children with sickle cell anemia on chronic transfusion therapy
Yee MEM, Josephson CD, Winkler AM, Webb J, Luban NLC, Leong T, Stowell SR, Roback JD, Fasano RM. Transfusion. 2018 Apr 17. doi: 10.1111/trf.14610.

CDC Grand Rounds: Improving the Lives of Persons with Sickle Cell Disease
Hulihan M, Hassell KL, Raphael JL, Smith-Whitley K, Thorpe P. MMWR Morb Mortal Wkly Rep. 2017 Nov 24;66(46):1269-1271. doi: 10.15585/mmwr.mm6646a2.

Red blood cell minor antigen mismatches during chronic transfusion therapy for sickle cell anemia
Yee MEM, Josephson CD, Winkler AM, Webb J, Luban NLC, Leong T, Stowell SR, Fasano RM. Transfusion. 2017 Nov;57(11):2738-2746. doi: 10.1111/trf.14282.

The accuracy of hospital ICD-9-CM codes for determining Sickle Cell Disease genotype
Snyder AB, Lane PA, Zhou M, Paulukonis ST, Hulihan MM. J Rare Dis Res Treat. 2017;2(4):39-45.

Emergency Department Utilization by Californians with Sickle Cell Disease, 2005-2014
Paulukonis ST, Feuchtbaum L, Coates TD, Neumayr LD, Treadwell MJ, Vichinsky EP, Hulihan MM. Pediatric Blood & Cancer. 2016 Dec 21. Published online ahead of print.

Community engagement to inform the development of a sickle cell counselor training and certification program in Ghana
Anie KA, Treadwell MJ, Grant AM, Dennis-Antwi JA, Asafo MK, Lamptey ME, Ojodu J, Yusuf C, Otaigbe A, Ohene-Frempong K. J Community Genet. 2016 Jul;7(3):195-202. doi: 10.1007/s12687-016-0267-3.

Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006-2010
Dupervil B, Grosse S, Burnett A, Parker C. PLoS One. 2016 Apr 14;11(4):e0153257. doi: 10.1371/journal.pone.0153257.

Defining Sickle Cell Disease Mortality Using a Population-Based Surveillance System, 2004 through 2008
Paulukonis ST, Eckman JR, Snyder AB, Hagar W, Feuchtbaum LB, Zhou M, Grant AM, Hulihan MM. Public Health Rep. 2016 Mar-Apr;131(2):367-75.

Observed and expected frequencies of structural hemoglobin variants in newborn screening surveys in Africa and the Middle East: deviations from Hardy-Weinberg equilibrium
Piel FB, Adamkiewicz TV, Amendah D, Williams TN, Gupta S, Grosse SD. Genet Med. 2016 Mar;18(3):265-74. doi: 10.1038/gim.2015.143.

Contribution of Sickle Cell Disease to the Pediatric Stroke Burden Among Hospital Discharges of African-Americans-United States, 1997-2012
Baker C, Grant AM, George MG, Grosse SD, Adamkiewicz TV. Pediatr Blood Cancer. 2015 Dec;62(12):2076-81. doi: 10.1002/pbc.25655.

Mortality of New York children with sickle cell disease identified through newborn screening
Wang Y, Liu G, Caggana M, Kennedy J, Zimmerman R, Oyeku SO, Werner EM, Grant AM, Green NS, Grosse SD. Genet Med. 2015 Jun;17(6):452-9. doi: 10.1038/gim.2014.123.

Health policy for sickle cell disease in Africa: experience from Tanzania on interventions to reduce under-five mortality
Makani J, Soka D, Rwezaula S, Krag M, Mghamba J, Ramaiya K, Cox SE, Grosse SD. Trop Med Int Health. 2015 Feb;20(2):184-7. doi: 10.1111/tmi.12428.

State-based surveillance for selected hemoglobinopathies
Hulihan MM, Feuchtbaum L, Jordan L, Kirby RS, Snyder A, Young W, Greene Y, Telfair J, Wang Y, Cramer W, Werner EM, Kenney K, Creary M, Grant AM. Genet Med. 2015 Feb;17(2):125-30. doi: 10.1038/gim.2014.81.

Attitudes toward Management of Sickle Cell Disease and Its Complications: A National Survey of Academic Family Physicians
Mainous AG 3rd, Tanner RJ, Harle CA, Baker R, Shokar NK, Hulihan MM. Anemia. 2015;2015:853835. doi: 10.1155/2015/853835.

Population based surveillance in sickle cell disease: methods, findings and implications from the California registry and surveillance system in hemoglobinopathies project (RuSH). Pediatr Blood Cancer
Paulukonis ST, Harris WT, Coates TD, Neumayr L, Treadwell M, Vichinsky E, Feuchtbaum LB. 2014 Dec;61(12):2271-6. doi: 10.1002/pbc.25208.

Incidence of sickle cell trait–United States, 2010
Ojodu J, Hulihan MM, Pope SN, Grant AM; Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. 2014 Dec 12;63(49):1155-8.

Obstetrician-gynecologists’ knowledge of sickle cell disease screening and management
Azonobi IC, Anderson BL, Byams VR, Grant AM, Schulkin J. BMC Pregnancy Childbirth. 2014 Oct 14;14:356. doi: 10.1186/1471-2393-14-356.

Discordance between self-report and genetic confirmation of sickle cell disease status in African-American adults
Bean CJ, Hooper WC, Ellingsen D, DeBaun MR, Sonderman J, Blot WJ. Public Health Genomics. 2014;17(3):169-72. doi: 10.1159/000360260.

Additional Selected Articles

Invasive pneumococcal disease among children with and without sickle cell disease in the United States, 1998 to 2009
Payne AB, Link-Gelles R, Azonobi I, Hooper WC, Beall BW, Jorgensen JH, Juni B, Moore M; Active Bacterial Core Surveillance Team. Pediatr Infect Dis J. 2013 Dec;32(12):1308-12. doi: 10.1097/INF.0b013e3182a11808.

Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia
Bean CJ, Boulet SL, Yang G, Payne AB, Ghaji N, Pyle ME, Hooper WC, Bhatnagar P, Keefer J, Barron-Casella EA, Casella JF, Debaun MR. Br J Haematol. 2013 Oct;163(2):268-76. doi: 10.1111/bjh.12507.

Hydroxyurea is associated with lower costs of care of young children with sickle cell anemia
Wang WC, Oyeku SO, Luo Z, Boulet SL, Miller ST, Casella JF, Fish B, Thompson BW, Grosse SD; BABY HUG Investigators. Pediatrics. 2013 Oct;132(4):677-83. doi: 10.1542/peds.2013-0333.

Sickle cell disease incidence among newborns in New York State by maternal race/ethnicity and nativity
Wang Y, Kennedy J, Caggana M, Zimmerman R, Thomas S, Berninger J, Harris K, Green NS, Oyeku S, Hulihan M, Grant AM, Grosse SD. Genet Med. 2013 Mar;15(3):222-8. doi: 10.1038/gim.2012.128.

Sickle cell disease in pregnancy: maternal complications in a Medicaid-enrolled population
Boulet SL, Okoroh EM, Azonobi I, Grant A, Craig Hooper W. Matern Child Health J. 2013 Feb;17(2):200-7. doi: 10.1007/s10995-012-1216-3.