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Treatment and Outcomes for Cryptococcosis

Cryptococcosis requires treatment with prescription antifungal medication for at least 6 months, usually longer. Treatment of severe cryptococcal infections, including those with central nervous system involvement, usually begins with amphotericin B, often in combination with flucytosine. For patients with asymptomatic or mild-to-moderate cryptococcosis, fluconazole or itraconazole are the preferred forms of treatment. Fluconazole can also be used for maintenance therapy in HIV-infected patients with cryptococcal meningoencephalitis.

For more information on the diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children, visit the World Health Organization website.

For healthcare providers: the most up-to-date guidelines for treating cryptococcal infections are available at the Infectious Diseases Society of America website.

 
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