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Histoplasmosis Risk & Prevention

Who gets histoplasmosis?

Anyone can get histoplasmosis if they’ve been in an area where Histoplasma lives in the environment. Histoplasmosis is often associated with activities that disturb soil, particularly soil that contains bird or bat droppings. Certain groups of people are at higher risk for developing the severe forms of histoplasmosis:

Is histoplasmosis contagious?

No. Histoplasmosis can’t spread from the lungs between people or between people and animals. However, in extremely rare cases, the infection can be passed through an organ transplant with an infected organ.7

If I've already had histoplasmosis, could I get it again?

It’s possible for someone who’s already had histoplasmosis to get it again, but the body’s immune system usually provides some partial protection so that the infection is less severe the second time. In people who have weakened immune systems, histoplasmosis can remain hidden in the body for months or years and then cause symptoms later (also called a relapse of infection).8

Can my pets get histoplasmosis?

Yes. Pets, particularly cats, can get histoplasmosis, but it is not contagious between animals and people.9 Histoplasmosis in cats and dogs is similar to histoplasmosis in humans. Like humans, many cats and dogs that are exposed to Histoplasma never get sick. Cats and dogs that do develop symptoms often have symptoms that include coughing, lack of energy, and weight loss. The fungus that causes histoplasmosis grows well in soil that contains bird droppings, but birds don’t appear to be able to get histoplasmosis. If you’re concerned about your pet’s risk of getting histoplasmosis or if you think that your pet has histoplasmosis, please talk to a veterinarian.

How can I prevent histoplasmosis?

It can be difficult to avoid breathing in Histoplasma in areas where it’s common in the environment. In areas where Histoplasma is known to live, people who have weakened immune systems (for example, by HIV/AIDS, an organ transplant, or medications such as corticosteroids or TNF-inhibitors) should avoid doing activities that are known to be associated with getting histoplasmosis, including:10

  • Disturbing material (for example, digging in soil or chopping wood) where there are bird or bat droppings
  • Cleaning chicken coops
  • Exploring caves
  • Cleaning, remodeling, or tearing down old buildings

Large amounts of bird or bat droppings should be cleaned up by professional companies that specialize in the removal of hazardous waste. Before starting a job or activity where there’s a possibility of being exposed to Histoplasma, consult the document Histoplasmosis: Protecting Workers at Risk [PDF - 39 pages].

What are public health agencies doing about histoplasmosis?

  • Surveillance. In some states, healthcare providers and laboratories are required to report histoplasmosis cases to public health authorities. Disease reporting helps government officials and healthcare providers understand how and why outbreaks occur and allows them to monitor trends in the number of histoplasmosis cases.
  • Developing better diagnostic tools. The symptoms of histoplasmosis can be similar to those of other respiratory diseases. Faster, more reliable methods to diagnosis histoplasmosis are in development, which could help minimize delays in treatment, save money and resources looking for other diagnoses, and reduce unnecessary treatment for other suspected illnesses.
  • Building laboratory capacity. Equipping laboratories in Latin America to be able to diagnose histoplasmosis and perform laboratory-based surveillance will help reduce the burden of HIV-associated histoplasmosis in these areas.


  1. Marukutira T, Huprikar S, Azie N, Quan SP, Meier-Kriesche HU, Horn DL. Clinical characteristics and outcomes in 303 HIV-infected patients with invasive fungal infections: data from the Prospective Antifungal Therapy Alliance registry, a multicenter, observational study. HIV/AIDS. 2014;6:39-47.
  2. McKinsey DS, McKinsey JP. Pulmonary histoplasmosis. Semin Respir Crit Care Med. 2011 Dec;32(6):735-44.
  3. Cuellar-Rodriguez J, Avery RK, Lard M, Budev M, Gordon SM, Shrestha NK, et al. Histoplasmosis in solid organ transplant recipients: 10 years of experience at a large transplant center in an endemic area. Clin Infect Dis. 2009 Sep 1;49(5):710-6.
  4. Smith JA, Kauffman CA. Endemic fungal infections in patients receiving tumour necrosis factor-alpha inhibitor therapy. Drugs. 2009 Jul 30;69(11):1403-15.
  5. Odio CM, Navarrete M, Carrillo JM, Mora L, Carranza A. Disseminated histoplasmosis in infants. Ped Infect Dis J. 1999 Dec;18(12):1065-8.
  6. Wheat LJ, Slama TG, Norton JA, Kohler RB, Eitzen HE, French ML, et al. Risk factors for disseminated or fatal histoplasmosis. Analysis of a large urban outbreak. Ann Intern Med. 1982 Feb;96(2):159-63.
  7. Roy M, Park BJ, Chiller TM. Donor-Derived Fungal Infections in Transplant Patients. Curr Fungal Infect Rep. 2010;4:219-28.
  8. Wheat LJ, Conces D, Allen SD, Blue-Hnidy D, Loyd J. Pulmonary histoplasmosis syndromes: recognition, diagnosis, and management. Semin Respir Crit Care Med. 2004 Apr;25(2):129-44.
  9. Bromel C, Sykes JE. Histoplasmosis in dogs and cats. Clinical techniques in small animal practice. 2005 Nov;20(4):227-32.
  10. Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H, et al. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR. 2009 Apr 10;58(RR-4):1-207.