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Sexually Transmitted Infections Treatment Guidelines, 2021
On July 10, 2025, King Pharmaceuticals, a subsidiary of Pfizer, issued a voluntary recall of specific referenced lots of Bicillin® L-A (Penicillin G Benzathine Injectable Suspension). Updates are available on FDA’s website. Further details and priority actions for health departments and healthcare providers are available in the Dear Colleague Letter.
CDC’s Sexually Transmitted Infections (STI) Treatment Guidelines, 2021 provides current evidence-based prevention, diagnostic and treatment recommendations that replace the 2015 guidance. The recommendations are intended to be a source for clinical guidance. Healthcare providers should always assess patients based on their clinical circumstances and local burden.
View the full STI Treatment Guidelines.
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- Suspected Gonorrhea Treatment Failure Consultation Form
- Mycoplasma genitalium Treatment Failure Registry
- Customizable Announcement
- Screening Recommendations
- Tables of Evidence
- A Guide to Taking a Sexual History
- Expedited Partner Therapy
- Availability of STI Testing & Treatment Products
- Prenatal Syphilis Screening Laws
- National STD Curriculum