Disease Threats and Global WASH Killers:
Cholera, Typhoid, and Other Waterborne Infections

Image of young girl outside holding a jug full of water

Safe water, sanitation, and hygiene (WASH) are fundamental to human health. Yet more than 884 million people globally have no safe water to drink.

Nearly 2.4 billion people lack access to basic sanitation facilities. Many people resort to open defecation—a practice that can endanger the safety of water used for drinking and personal use.

Infants and children are more likely to die due to lack of access to safe water.

Many diarrheal diseases spread through unsafe water and sanitation. These condi­tions, along with poor hygiene, can also cause the deadly diseases cholera and typhoid fever. Poor WASH conditions are also linked to emerging challenges such as extensively drug-resistant typhoid fever.

Focused efforts are needed to accelerate and sustain progress toward eliminating WASH-related diseases and emerging threats like antibiotic-resistant infections.

Preventable Diseases

Each year…

  • 1.7 billion cases among children under 5
  • 3 million cases
  • 95,000 deaths
Typhoid Fever
  • 11 million cases
  • 117,000 deaths

The Global Impact of Waterborne Infections and WASH-related Diseases

  • Many waterborne infections cause diarrhea and loss of body fluids, resulting too often in severe dehydration and death. Diarrhea is the fifth-leading cause of death among children under the age of 5.
  • Frequent and recurring diarrhea can reduce children’s growth and cognitive development and increase their susceptibility to other infectious diseases.
  • About 88% of diarrhea-associated deaths are due to unsafe water, inadequate sanitation, and insufficient hygiene.
Graphic of Diarrheal Risk Factors of 77% from inadequate WASH, 54% from unsafe sanitation, 34% from lack of handwashing facilities, and 70% from unsafe water

Ending Cholera: A Roadmap to 2030

In 2017, the Global Task Force on Cholera Control launched Ending Cholera: The Global Roadmap to 2030. The declaration calls for a collective approach to reduce cholera deaths by 90% and to eliminate local disease transmission by 2030 in 20 countries.

  • Infections cause extreme diarrhea with rapid loss of body fluids and can be fatal within hours if not treated.
  • Cholera has been reported in 47 countries worldwide, and is most likely to affect the poorest and most vulnerable populations, including young children and older adults.
  • Global efforts which primarily focus on outbreak response are shifting to include long-term prevention initiatives through improved WASH and oral cholera vaccines.
Typhoid Fever
  • Typhoid fever is a bacterial disease spread by drinking or eating contaminated water or food.
  • The first known outbreak of a strain of extensively drug-resistant (XDR) typhoid fever in Pakistan resulted in over 10,000 cases from 2016-2019, including 30 cases in the United States.
  • This XDR strain does not respond to most antibiotics, making infections harder to treat.
  • As treatment options become more limited, further preventive measures are urgently needed to prevent typhoid infections and deaths, such as improved sanitation and hygiene, and typhoid vaccination campaigns.

Improving Access to WASH in Resource-limited Settings

For every $1 invested in water and sanitation, $4 will be saved in global healthcare costs.

Making progress on WASH challenges in healthcare facilities and community settings in low- and middle-income countries will require commitment and resource mobilization at the local, national, and global levels.

Healthcare Clinics

Ensuring access in healthcare facilities to safe drinking water, handwashing facilities, and safe disposal of human waste, among other prevention strategies for infection control, can help prevent disease transmission and reduce the spread of antimicrobial resistance.

image of patients with safe drinking water

Safe Water
Safe drinking water for patients and staff

Image of 3 outdoor isolated bathroom facilities

Clean and maintained toilets or latrines that isolate or treat waste effectively

Image of hands being washed from an outside water despenser

Handwashing stations with sinks, soap and water, and alcohol-based hand sanitizer for clinic staff


Identifying WASH challenges and implementing solutions in households, schools, and other community settings can help prevent diarrhea, cholera, typhoid fever, or some antibiotic-resistant infections.

Image of young girl getting water from a well in a plastic container

Safe Water
Improve access to safe community water systems and household water treatment

Image of woman handling a mobile porter potty

Manage fecal waste using new approaches

Image of young girls having access to  outdoor handwashing facilities

Increase access to and use of handwashing facilities

Taking Action

CDC’s Waterborne Disease Prevention Branch works with partners to reduce the global burden of waterborne infections in the following ways:

Supporting the Ending Cholera Initiative
Close up of several hands being washed with clean water
  • Working as a founding member of the Global Task Force on Cholera Control
  • Providing expertise to countries that have committed to the Ending Cholera initiative by supporting WASH disease prevention measures, cholera treatment, surveillance, laboratory testing, epidemiologic studies and vaccines
  • Working with the World Health Organization, UNICEF, Doctors Without Borders, the International Federation of the Red Cross, and other institutions to reduce cholera deaths by 90% in 20 countries by 2030
  • Improving cholera surveillance, treatment, laboratory testing, outbreak preparedness, and prevention through targeted WASH interventions and vaccination campaigns
Combating XDR Typhoid
  • Working with Ministries of Health and Ministries of Water globally to improve typhoid surveillance, community water treatment, and community WASH practices in typhoid endemic areas, especially municipal settings where antibiotic resistance is a big concern
  • Educating clinicians in the United States and abroad on approaches for diagnosing typhoid fever, testing for antibiotic resistance, and properly treating patients diagnosed with XDR typhoid
  • Educating people on the importance of typhoid vaccination before travel to endemic areas and on safe food and water practices while traveling
Improving WASH in Limited Resource Settings
  • Working with governmental partners, Ministries of Health and Water, and non-governmental aid organizations to include water, sanitation, hygiene, and waste management for healthcare facilities
  • Supporting the UN’s Sustainable Development Goals
  • Training public health workers on the importance of WASH-based practices 
Improving WASH Around the Globe

Safe Water

Adequate Sanitation

Improved Hygiene