Reported Cases of Hantavirus Disease
Hantavirus disease surveillance in the United States began in 1993 during an outbreak of severe respiratory illness in the Four Corners region – the area where Arizona, Colorado, New Mexico, and Utah meet. Hantavirus pulmonary syndrome (HPS) became a nationally notifiable disease in 1995 and is now reported through the Nationally Notifiable Disease Surveillance System (NNDSS) when fever is present in a patient with laboratory-confirmed evidence of hantavirus infection.
In 2014, the Council of State & Territorial Epidemiologists expanded the national reporting of laboratory-confirmed hantavirus infections to include HPS and non-pulmonary hantavirus infection, an illness with non-specific viral symptoms, such as fever, chills, headache, fatigue, but no cardio-pulmonary symptoms. Reporting of non-pulmonary hantavirus cases began in 2015.
As of the end of 2019*, 816 cases of hantavirus disease were reported in the United States since surveillance began in 1993. These were all laboratory-confirmed cases and included HPS and non-pulmonary hantavirus infection.
The map below shows the distribution by state of hantavirus cases in the United States from 1993 through 2019.
Data is reported by state only. County-level data for hantavirus cannot be provided to protect the identities of the people who contracted hantavirus. Contact your local or state health department for information about hantavirus disease cases in your area.
* Due to the case review and confirmation process, annual hantavirus case information is reported in the spring of the following year. Reporting of annual case information is delayed due to the COVID-19 pandemic.
The following table is based on the national surveillance data reported to CDC’s Viral Special Pathogens Branch and collected by the NNDSS.
Table 1. Hantavirus Disease** Characteristics in the United States
Cases of hantavirus infection, as of December 2019
Patients ill with HPS (Sex)
Patients ill with HPS (Race)
17% American Indian
1% African American
Mean age of confirmed case patients
39 years (range 5 to 84 years)
Reported cases of hantavirus disease resulting in death.
Cases occurring in states west of the Mississippi River
** Hantavirus disease includes HPS and non-pulmonary hantavirus infection