At a glance
- These clinical considerations provide guidance to healthcare professionals and public health officials on use of COVID-19 vaccines.
- The Table of Contents on each page can be used to navigate to all guidance pages.
- A PDF version of the complete clinical considerations is available below to download and print.
Summary of recent changes
Last updated November 4, 2025
- The COVID-19 vaccination recommendations have been updated to reflect individual-based decision-making (also known as shared clinical decision-making) for people ages 6 months and older.
- Pfizer-BioNTech COVID-19 Vaccine is no longer authorized for children ages 6 months–4 years. The only FDA-approved COVID-19 vaccine available for this age group is Moderna (Spikevax).
Download the clinical considerations
Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States