Gonorrhea / Neonates (up to 4 weeks)

Erythromycin 0.5% ophthalmic ointment in each eye in a single application at birth 

If erythromycin ointment is unavailable, infants at risk for exposure to N. gonorrhoeae, especially those born to a mother at risk for gonococcal infection or with no prenatal care, can be administered ceftriaxone 25–50 mg/kg body weight IV or IM, not to exceed 250 mg in a single dose. 

Ceftriaxone 25–50 mg/kg body weight IV or IM in a single dose, not to exceed 250 mg 

Ceftriaxone should be administered cautiously to neonates with hyperbilirubinemia, especially those born prematurely. 

Cefotaxime 100 mg/kg body weight IV or IM as a single dose can be administered for those neonates unable to receive ceftriaxone because of simultaneous administration of IV calcium. 

Ceftriaxone 25–50 mg/kg body weight/day IV or IM in a single daily dose for 7 days, with a duration of 10–14 days if meningitis is documented  

OR 

Cefotaxime 25 mg/kg body weight/day IV or IM every 12 hours for 7 days, with a duration of 10–14 days if meningitis is documented 

Ceftriaxone should be administered cautiously to neonates with hyperbilirubinemia, especially those born prematurely. 

Cefotaxime 100 mg/kg body weight IV or IM as a single dose can be administered for those neonates unable to receive ceftriaxone because of simultaneous administration of IV calcium. 

Ceftriaxone 20–50 mg/kg body weight IV or IM in a single dose, not to exceed 250 mg 

Ceftriaxone should be administered cautiously to neonates with hyperbilirubinemia, especially those born prematurely. 

Cefotaxime 100 mg/kg body weight IV or IM as a single dose can be administered for those neonates unable to receive ceftriaxone because of simultaneous administration of IV calcium.