Lymphogranuloma Venereum (LGV)
Doxycycline 100 mg orally 2 times/day for 21 days
Azithromycin 1 g orally once weekly for 3 weeks*
Erythromycin base 500 mg orally 4 times/day for 21 days
* Because this regimen has not been validated, a test of cure with C. trachomatis NAAT 4 weeks after completion of treatment can be considered.
Azithromycin might prove useful for LGV treatment during pregnancy, at a presumptive dose of 1 g weekly for 3 weeks; no published data are available regarding an effective dose and duration of treatment.
Pregnant and lactating women with LGV can be treated with erythromycin, although this regimen is associated with frequent gastrointestinal side effects.
*Pregnant women treated for LGV should have a test of cure performed 4 weeks after the initial C. trachomatis NAAT-positive test.
Persons with LGV and HIV infection should receive the same regimens as those who do not have HIV. Prolonged therapy might be required because a delay in resolution of symptoms might occur.