Pelvic Inflammatory Disease
Ceftriaxone 1 g IV every 24 hours
PLUS
Doxycycline 100 mg orally or IV every 12 hours
PLUS
Metronidazole 500 mg orally or IV every 12 hours
OR
Cefotetan 2 g IV every 12 hours
PLUS
Doxycycline 100 mg orally or IV every 12 hours
OR
Cefoxitin 2 g IV every 6 hours
PLUS
Doxycycline 100 mg orally or IV every 12 hours
Ampicillin-sulbactam 3 g IV every 6 hours
PLUS
Doxycycline 100 mg orally or IV every 12 hours
OR
Clindamycin 900 mg IV every 8 hours
PLUS
Gentamicin loading dose IV or IM (2 mg/kg body weight), followed by a maintenance dose (1.5 mg/kg body weight) every 8 hours; single daily dosing (3–5 mg/kg body weight) can be substituted
Ceftriaxone 500 mg* IM in a single dose
PLUS
Doxycycline 100 mg orally 2 times/day for 14 days with metronidazole 500 mg orally 2 times/day for 14 days
OR
Cefoxitin 2 g IM in a single dose and probenecid 1 g orally administered concurrently in a single dose
PLUS
Doxycycline 100 mg orally 2 times/day for 14 days with metronidazole 500 mg orally 2 times/day for 14 days
OR
Other parenteral third-generation cephalosporin (e.g., ceftizoxime or cefotaxime)
PLUS
Doxycycline 100 mg orally 2 times/day for 14 days with metronidazole 500 mg orally 2 times/day for 14 days
* For persons weighing ≥150 kg, 1 g of ceftriaxone should be administered.