Syphilis / Tertiary

Tertiary syphilis without evidence of neurosyphilis by clinical and CSF examination:   

Benzathine penicillin G 7.2 million units total, administered as 3 doses of 2.4 million units IM each at 1-week intervals 

Tertiary syphilis without evidence of neurosyphilis by clinical and CSF examination: 

Benzathine penicillin G 7.2 million units total, administered as 3 doses of 2.4 million units IM at 1-week intervals 

Pregnant women should be treated with the recommended penicillin regimen for their stage of infection. 

Parenteral penicillin G is the only therapy with documented efficacy for syphilis during pregnancy. Pregnant women who are allergic to penicillin should be desensitized and treated with penicillin G. Skin testing or oral graded penicillin dose challenge might be helpful in identifying women at risk for acute allergic reactions.