Nongonococcal Urethritis (NGU)

Recommended Regimen

Doxycycline 100 mg orally 2 times/day for 7 days 

Alternative Regimen

Azithromycin 1 g orally in a single dose  


Azithromycin 500 mg orally in a single dose; then 250 mg orally daily for 4 days 

Persistent or Recurrent Nongonococcal Urethritis

The objective diagnosis of persistent or recurrent NGU should be made before considering additional antimicrobial therapy. Symptomatic recurrent or persistent urethritis might be caused by treatment failure or reinfection after successful treatment. Among men who have persistent symptoms after treatment without objective signs of urethral inflammation, the value of extending the duration of antimicrobials has not been demonstrated.  The initial step in recurrent urethritis is assessing compliance with treatment or potential reexposure to an untreated sex partner. If the patient did not comply with the treatment regimen or was reexposed to an untreated partner, retreatment with the initial regimen can be considered. If therapy was appropriately completed and no reexposure occurred, therapy is dependent on the initial treatment regimen. Ideally, diagnostic testing among men with recurrent or persistent symptoms, including those with gonorrhea, chlamydia, M. genitalium, and trichomoniasis, can be used to guide further management decisions. 

Page last reviewed: July 16, 2021
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