Table 35. Trends in Reported Cases and Rates of Reported Cases for Nationally Notifiable STIs, United States, 2018–2022
| Disease | Sex* | Cases | Percent Change | |||||
|---|---|---|---|---|---|---|---|---|
| 2018 | 2019 | 2020 | 2021 | 2022 | 5 Year | 1 Year | ||
| Chlamydia | Men | 610,447 | 644,337 | 548,676 | 587,473 | 601,205 | -1.5 | 2.3 |
| Women | 1,145,063 | 1,160,470 | 1,027,061 | 1,053,246 | 1,043,573 | -8.9 | -0.9 | |
| Total | 1,758,668 | 1,808,703 | 1,579,885 | 1,644,416 | 1,649,716 | -6.2 | 0.3 | |
| Gonorrhea | Men | 341,401 | 361,586 | 385,551 | 410,388 | 390,548 | 14.4 | -4.8 |
| Women | 241,074 | 253,359 | 290,666 | 298,015 | 255,566 | 6.0 | -14.2 | |
| Total | 583,405 | 616,392 | 677,769 | 710,151 | 648,056 | 11.1 | -8.7 | |
| Primary and Secondary Syphilis | Men | 30,034 | 32,402 | 33,646 | 41,349 | 44,309 | 47.5 | 7.2 |
| Women | 4,995 | 6,493 | 7,901 | 12,265 | 14,652 | 193.3 | 19.5 | |
| Total | 35,063 | 38,992 | 41,655 | 53,767 | 59,016 | 68.3 | 9.8 | |
| Early Non-Primary Non-Secondary Syphilis | Men | 32,619 | 34,427 | 35,165 | 40,979 | 44,143 | 35.3 | 7.7 |
| Women | 5,891 | 7,081 | 7,809 | 10,668 | 12,674 | 115.1 | 18.8 | |
| Total | 38,539 | 41,655 | 43,145 | 51,830 | 56,913 | 47.7 | 9.8 | |
| Unknown Duration or Late Syphilis | Men | 28,872 | 32,411 | 31,868 | 44,548 | 55,094 | 90.8 | 23.7 |
| Women | 11,232 | 14,598 | 14,959 | 23,474 | 32,347 | 188.0 | 37.8 | |
| Total | 40,137 | 47,296 | 46,997 | 68,261 | 87,571 | 118.2 | 28.3 | |
| Congenital Syphilis† | Total | 1,325 | 1,882 | 2,162 | 2,875 | 3,755 | 183.4 | 30.6 |
| Total Syphilis‡ | Total | 115,064 | 129,825 | 133,959 | 176,733 | 207,255 | 80.1 | 17.3 |
| Combined Total of Chlamydia, Gonorrhea, and Total Syphilis | Total | 2,457,137 | 2,554,920 | 2,391,613 | 2,531,300 | 2,505,027 | 1.9 | -1.0 |
| Disease | Sex* | Rates per 100,000 Population | Percent Change | |||||
|---|---|---|---|---|---|---|---|---|
| 2018 | 2019 | 2020 | 2021 | 2022 | 5 Year | 1 Year | ||
| Chlamydia | Men | 378.9 | 398.6 | 334.2 | 357.4 | 363.7 | -4.0 | 1.8 |
| Women | 689.6 | 696.6 | 614.1 | 628.8 | 621.2 | -9.9 | -1.2 | |
| Total | 537.5 | 551.0 | 476.7 | 495.5 | 495.0 | -7.9 | -0.1 | |
| Gonorrhea | Men | 211.9 | 223.7 | 234.8 | 249.7 | 236.3 | 11.5 | -5.4 |
| Women | 145.2 | 152.1 | 173.8 | 177.9 | 152.1 | 4.8 | -14.5 | |
| Total | 178.3 | 187.8 | 204.5 | 214.0 | 194.4 | 9.0 | -9.2 | |
| Primary and Secondary Syphilis | Men | 18.6 | 20.0 | 20.5 | 25.2 | 26.8 | 44.1 | 6.3 |
| Women | 3.0 | 3.9 | 4.7 | 7.3 | 8.7 | 190.0 | 19.2 | |
| Total | 10.7 | 11.9 | 12.6 | 16.2 | 17.7 | 65.4 | 9.3 | |
| Early Non-Primary Non-Secondary Syphilis | Men | 20.2 | 21.3 | 21.4 | 24.9 | 26.7 | 32.2 | 7.2 |
| Women | 3.5 | 4.3 | 4.7 | 6.4 | 7.5 | 114.3 | 17.2 | |
| Total | 11.8 | 12.7 | 13.0 | 15.6 | 17.1 | 44.9 | 9.6 | |
| Unknown Duration or Late Syphilis | Men | 17.9 | 20.0 | 19.4 | 27.1 | 33.3 | 86.0 | 22.9 |
| Women | 6.8 | 8.8 | 8.9 | 14.0 | 19.3 | 183.8 | 37.9 | |
| Total | 12.3 | 14.4 | 14.2 | 20.6 | 26.3 | 113.8 | 27.7 | |
| Congenital Syphilis† | Total | 34.9 | 50.2 | 59.8 | 78.5 | 102.5 | 193.7 | 30.6 |
| Total Syphilis‡ | Total | 35.2 | 39.6 | 40.4 | 53.2 | 62.2 | 76.7 | 16.9 |
| Combined Total of Chlamydia, Gonorrhea, and Total Syphilis | Total | 751.0 | 778.4 | 721.6 | 762.7 | 751.6 | 0.1 | -1.5 |
| * Total includes cases reported with unknown sex. † Sex of infant is not reported. Rates are per 100,000 live births. ‡ Total includes cases of congenital syphilis. NOTE: This report includes data from years that coincide with the COVID-19 pandemic, which introduced uncertainty and difficulty in interpreting case data. See Impact of COVID-19 on STIs for more information. |
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