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The tables in this report highlight current trends for nationally notifiable STIs, including chlamydia, gonorrhea, and syphilis, and supersede those in earlier publications of these data.

Trends presented in Sexually Transmitted Disease Surveillance, 2021 should be interpreted cautiously. For more information, see Impact of COVID-19 on STDs.

State Rankings Tables are available in Table 2, Table 7, Table 13, and Table 20.

They can also be downloaded as a PDF.

Table 12. Total Syphilis* — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2017-2021

Table 13. Primary and Secondary Syphilis — Reported Cases and Rates of Reported Cases by State, Ranked by Rates, United States, 2021

Table 14. Primary and Secondary Syphilis — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2017–2021

Table 14A. Primary and Secondary Syphilis Among Men — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2017–2021

Table 14B. Primary and Secondary Syphilis Among Women — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2017–2021

Table 15. Primary and Secondary Syphilis — Reported Cases and Rates of Reported Cases by Age Group and Sex, 2017–2021

Table 16A. Primary and Secondary Syphilis — Reported Cases by Race/Hispanic Ethnicity, Age Group, and Sex, United States, 2021

Table 16B. Primary and Secondary Syphilis — Rates of Reported Cases* by Race/Hispanic Ethnicity, Age Group, and Sex, United States, 2021

Table 17. Primary and Secondary Syphilis —Reported Cases* and Rates of Reported Cases Among Gay, Bisexual, and Other Men Who Have Sex with Men by State in Alphabetical Order, United States, 2017–2021

Table 18. Early Non-Primary Non-Secondary Syphilis — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States and Territories, 2017–2021

Table 19. Unknown Duration or Late Syphilis* — Reported Cases and Rates of Reported Cases by State/Territory and Region in Alphabetical Order, United States, 2017–2021

Table 20. Congenital Syphilis — Reported Cases and Rates of Reported Cases by State, Ranked by Rates, United States, 2021

Table 21. Congenital Syphilis — Reported Cases and Rates of Reported Cases by Year of Birth, by State/Territory* and Region in Alphabetical Order, United States, 2017–2021

Table 22. Congenital Syphilis — Reported Cases and Rates of Reported Cases* by Year of Birth and Race/Hispanic Ethnicity of Mother, United States, 2017–2021

Table 23. Syphilis — Reported Cases and Rates of Total Syphilis (All Stages) Among Women Aged 15-44 Years and Reported Cases and Rates of Congenital Syphilis by State/Territory* and Region in Alphabetical Order, United States, 2021