Table 24. Trends in Reported Cases and Rates of Reported Cases for Nationally Notifiable STDs, United States, 2016-2020

Table 24. Trends in Reported Cases and Rates of Reported Cases for Nationally Notifiable STDs, United States, 2016-2020
Disease Sex*
Cases
Percent Change
2016 2017 2018 2019 2020 5 Year 1 Year
Chlamydia Men 522,870 577,644 610,447 644,337 548,676 4.9 -14.8
Women 1,072,719 1,127,651 1,145,063 1,160,470 1,027,061 -4.3 -11.5
Total 1,598,354 1,708,569 1,758,668 1,808,703 1,579,885 -1.2 -12.7
Gonorrhea Men 270,033 322,169 341,401 361,586 385,551 42.8 6.6
Women 197,499 232,587 241,074 253,359 290,666 47.2 14.7
Total 468,514 555,608 583,405 616,392 677,769 44.7 10.0
Total Syphilis Total 88,055 101,590 115,062 129,818 133,945 52.1 3.2
   Congenital Syphilis† Total 641 941 1,323 1,875 2,148 235.1 14.6
   Primary and Secondary Syphilis Men 24,724 26,885 30,034 32,402 33,646 36.1 3.8
Women 3,049 3,722 4,995 6,493 7,901 159.1 21.7
Total 27,814 30,644 35,063 38,992 41,655 49.8 6.8
   Early Non-Primary Non-Secondary Syphilis Men 24,919 29,251 32,619 34,427 35,165 41.1 2.1
Women 3,939 4,684 5,891 7,081 7,809 98.2 10.3
Total 28,924 34,013 38,539 41,655 43,145 49.2 3.6
   Unknown Duration or Late Syphilis‡ Men 22,785 26,178 28,872 32,411 31,868 39.9 -1.7
Women 7,850 9,740 11,232 14,598 14,959 90.6 2.5
Total 30,676 35,992 40,137 47,296 46,997 53.2 -0.6
Combined Total of Chlamydia, Gonorrhea, and Total Syphilis Total 2,154,923 2,365,767 2,457,135 2,554,913 2,391,599 11.0 -6.4
Table 24. Trends in Reported Cases and Rates of Reported Cases for Nationally Notifiable STDs, United States, 2016-2020
Disease Sex*
Rates per 100,000 Population
Percent Change
2016 2017 2018 2019 2020 5 Year 1 Year
Chlamydia Men 328.7 360.1 378.9 398.6 339.4 3.3 -14.9
Women 653.9 682.1 689.6 696.6 616.5 -5.7 -11.5
Total 494.7 524.6 537.5 551.0 481.3 -2.7 -12.6
Gonorrhea Men 169.7 200.8 211.9 223.7 238.5 40.5 6.6
Women 120.4 140.7 145.2 152.1 174.5 44.9 14.7
Total 145.0 170.6 178.3 187.8 206.5 42.4 10.0
Total Syphilis Total 27.3 31.2 35.2 39.5 40.8 49.5 3.3
   Congenital Syphilis† Total 16.2 24.4 34.9 50.0 57.3 253.7 14.6
   Primary and Secondary Syphilis Men 15.5 16.8 18.6 20.0 20.8 34.2 4.0
Women 1.9 2.3 3.0 3.9 4.7 147.4 20.5
Total 8.6 9.4 10.7 11.9 12.7 47.7 6.7
   Early Non-Primary Non-Secondary Syphilis Men 15.7 18.2 20.2 21.3 21.8 38.9 2.3
Women 2.4 2.8 3.5 4.3 4.7 95.8 9.3
Total 9.0 10.4 11.8 12.7 13.1 45.6 3.1
   Unknown Duration or Late Syphilis‡ Men 14.3 16.3 17.9 20.0 19.7 37.8 -1.5
Women 4.8 5.9 6.8 8.8 9.0 87.5 2.3
Total 9.5 11.1 12.3 14.4 14.3 50.5 -0.7
Combined Total of Chlamydia, Gonorrhea, and Total Syphilis Total 666.9 726.3 751.0 778.4 728.6 9.3 -6.4
* Total includes cases reported with unknown sex.

† Sex of infant is not reported. Rates are per 100,000 live births.

‡ The case classification of ‘Unknown duration or late syphilis’ went into effect in January 2018. During 2016–2017, cases in this category include cases classified as late latent syphilis and late syphilis with clinical manifestations. See Technical Notes for a detailed explanation of changes to the syphilis case definition.

NOTE: The COVID-19 pandemic has introduced uncertainty and difficulty in interpreting 2020 case data. See Impact of COVID-19 on STDs for more information.

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