The Review of 19 Draft Skin Notation Assignments and Skin Notation Profiles

May 2015
NIOSH Docket Number 153-C, CDC-2015-0021

The purpose of the Skin Notation Profiles is to summarize the available data on the hazards of dermal exposure to the chemical(s)-of-interest and provide the scientific rationale for the assignment of hazard-specific skin notations (SK) for systemic, direct, and sensitizing effects. These technical documents have been designed to provide exposure recommendations to occupational health practitioners, researchers, policy- and decision-makers, employers, and workers concerned about dermal exposures so that improved risk-management practices may be developed to better protect workers from the risks of dermal contact with the chemical(s)-of-interest. Historically, skin notations have been published in the NIOSH Pocket Guide to Chemical Hazards [NIOSH 2005-149], and this practice will continue for each evaluated chemical. The Skin Notation Profiles do not have the force and effect of law.

Document Review Process: In 2015, NIOSH posted in the Federal Register [80 FR 24932] an announcement of the availability of the draft Skin Notation Profiles for public review and comment. The external review, which included reviews by peers, stakeholders, and the public, was conducted in accordance with the Office of Management and Budget (OMB) guidelines under the Federal Data Quality Act 2000 (Public Law 106-554, Section 1(a)(3)[515]) based on the classification of the draft technical reports by NIOSH as a Highly Influential Scientific Assessments (HISA). The draft technical reports were submitted for review to peers that were selected because they are recognized as subject matter experts (SMEs) in the fields of toxicology, industrial hygiene, occupational medicine, dermatology, and human health risk assessment. In addition, stakeholders and the public were provided the opportunity to review the draft technical reports and submit comments via the Federal rulemaking portal: https://www.regulations.govexternal icon and the NIOSH docket office. All comments that were received during the external review were evaluated for their scientific and technical merit. The final Skin Notation Profiles include changes that are based on the comments submitted from peer reviewers, in addition to stakeholders and the public.

To view the notice and related materials, visit https://www.regulations.govexternal icon and enter CDC-2015-0021 in the search field and click “Search.”

Final Skin Notation Profiles

The following 19 NIOSH Skin Notation Profile documents include changes that are based on the comments submitted from peer reviewers, in addition to the stakeholders and public.

Skin Notation Profiles
Document# Substance(s)
CAS No. 79-01-7 Acrylic acid
CAS No. 7440-38-2 Arsenic and compounds
CAS No. 1912-24-9 Atrazinepdf icon
CAS No. 106-94-5 1-Bromopropane
CAS No. 120-80-9 Catecholpdf icon
CAS No. 8001-35-2 Chlorinated camphenepdf icon
CAS No. 62-73-7 Dichlorvos
CAS No. 77-78-1 Dimethyl sulfate
CAS No. 78-34-2 Dioxathion
CAS No. 298-04-4 Disulfoton
CAS No. 2104-64-5 Ethyl p-nitrophenyl phenylphosphorothioate (EPN)
CAS No. 76-44-8 Heptachlor
CAS No. 999-61-1 2-Hydroxypropyl acrylate
CAS No. 110-91-8 Morpholine
CAS No. 87-86-5 Pentachlorophenol (PCP)pdf icon
CAS No. 62-74-8 Sodium fluoroacetatepdf icon
CAS No. 78-00-2 Tetraethyl leadpdf icon
CAS No. 75-74-1 Tetramethyl leadpdf icon
CAS No. 79-01-6 Trichloroethylenepdf icon

To view the final Skin Notation Profiles visit the Skin Notation Profiles website.

Page last reviewed: August 31, 2017