Technical Review of 25 Draft Skin Notation Profiles

September 2014
NIOSH Docket Number 153-B, CDC-2013-0022

The purpose of the Skin Notation Profiles is to summarize the available data on the hazards of dermal exposure to the chemical(s)-of-interest and provide the scientific rationale for the assignment of hazard-specific skin notations (SK) for systemic, direct, and sensitizing effects. These technical documents have been designed to provide exposure recommendations to occupational health practitioners, researchers, policy- and decision-makers, employers, and workers concerned about dermal exposures so that improved risk-management practices may be developed to better protect workers from the risks of dermal contact with the chemical(s)-of-interest. Historically, skin notations have been published in the NIOSH Pocket Guide to Chemical Hazards [NIOSH 2005-149] , and this practice will continue for each evaluated chemical. The Skin Notation Profiles do not have the force and effect of law.

Document Review Process: In 2013, NIOSH posted in the Federal Register [78 FR 70047] an announcement of the availability of the draft Skin Notation Profiles for public review and comment. The external review, which included reviews by peers, stakeholders, and the public, was conducted in accordance with the Office of Management and Budget (OMB) guidelines under the Federal Data Quality Act 2000 (Public Law 106-554, Section 1(a)(3)[515]) based on the classification of the draft technical reports by NIOSH as a Highly Influential Scientific Assessments (HISA). The draft technical reports were submitted for review to peers that were selected because they are recognized as subject matter experts (SMEs) in the fields of toxicology, industrial hygiene, occupational medicine, dermatology, and human health risk assessment. In addition, stakeholders and the public were provided the opportunity to review the draft technical reports and submit comments via the Federal rulemaking portal: https://www.regulations.govexternal icon and the NIOSH docket office. All comments that were received during the external review were evaluated for their scientific and technical merit. The final Skin Notation Profiles include changes that are based on the comments submitted from peer reviewers, in addition to stakeholders and the public.

To view the notice and related materials, visit https://www.regulations.govexternal icon and enter CDC-2013-0022 in the search field and click “Search.”

Final Skin Notation Profiles

  • Aldrin (CAS# 309-00-2)
  • Allyl glycidyl ether (CAS# 108-92-3)
  • Aniline (CAS# 62-53-3)
  • Azinphos-methyl (CAS# 86-50-0)
  • Captafol (CAS# 2425-06-1)
  • Chlordane and Technical Grade Chlordane (CAS# 57-74-9; 127889-03-6)
  • Dieldrin (CAS# 60-57-1)
  • Dinitro-o-cresol (CAS# 534-52-1)
  • 2-Diethylaminoethanol (CAS# 100-37-8)
  • Endrin (CAS# 72-20-8)
  • 2-Ethoxyethyl acetate (CAS# 111-15-9)
  • Ethyl acrylate (CAS# 140-88-5)
  • Isophorone diisocyanate (CAS# 4098-71-9)
  • 2-Mercaptobenzothiazole, Sodium 2-Mercaptobenzothiazole, Zinc 2-Mercaptobenzothiazole (CAS# 149-30-4; 2492-26-4; and 155-04-4)
  • Methyl isocyanate (CAS# 624-83-9)
  • Methyl parathion (CAS# 298-00-0)
  • Nicotine (CAS# 54-11-5)
  • Nitrobenzene (CAS# 98-95-3)
  • Parathion (CAS# 56-38-2)
  • Phorate (CAS# 298-02-2)
  • Phosdrin (CAS# 7786-34-7)
  • Propargyl alcohol (CAS# 107-19-7)
  • Phenylhydrazine (CAS# 100-63-0)
  • Tetraethyl dithionopyrophosphate (TEDP) (CAS# 3689-24-5)
  • Tetraethyl pyrophosphate (TEPP) (CAS# 107-49-3)

To view the final Skin Notation Profiles visit the Skin Notation Profiles website.

Background Information

Revised Final Document: NIOSH Current Intelligence Bulletin (CIB) 61: A strategy for Assigning New NIOSH Skin Notation – 8/1/17pdf icon

Final document: NIOSH Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations; 2009-147 – 7/1/09pdf icon

Federal Register Notice: Notice of issuance of final guidance publicationspdf iconexternal icon (10/13/2015)

Federal Register Notice: Issuance of final guidance document; 79FR58352pdf iconexternal icon (9/29/2014)

Federal Register Notice: Request for comments; 78FR70047pdf iconexternal icon (11/22/2013)

Page last reviewed: August 31, 2017