Skin Notation Strategy

Historically, skin notations have been published in the NIOSH Pocket Guide to Chemical Hazards. This practice will continue with the NIOSH skin notation assignments for each evaluated chemical being integrated as they become available. A support document called a Skin Notation Profile has been developed for each evaluated chemical. The Skin Notation Profile for a chemical is intended to provide information supplemental to the skin notation, including a summary of all relevant data used to aid in determining the hazards associated with skin exposures.

NIOSH obtained comments on the draft skin notation assignments and Skin Notation Profiles for 22 chemicals. The submissions are listed below.

Note: To view the final Skin Notation Profiles visit the Skin Notation Profiles website .

Background Information

Revised Final Document: NIOSH Current Intelligence Bulletin (CIB): 61: A strategy for Assigning New NIOSH Skin Notations – 8/1/17 pdf icon[PDF – 2 MB]

Final document: NIOSH Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations; 2009-147 – 7/1/09pdf icon

Peer reviewer summary of comments – 06/01/10pdf icon [PDF – 3,712 KB]

Notice of public comment period; 75 FR 22148 – 04/27/10pdf icon [PDF – 3,628 KB]

Charge to Reviewers – 04/27/10pdf icon [PDF – 1,287 KB]

Peer Reviewer Submissions on 22 Chemicals (in Numerical Order)

• A-01 1, 3-Dichloropropene (CAS # 542–75–6): Submission to the docket from peer reviewers on 1,3-Dichloropropene – 06/01/10pdf icon [PDF – 3,483 KB]
• A-02 Phenol (CAS # 108–95–2): Submission to the docket from peer reviewers on Phenol – 06/01/10pdf icon [PDF – 2,381 KB]
• A-03 Hydrogen fluoride/hydrofluoric acid (CAS # 7664–39–3): Submission to the docket from peer reviewers on Hydrogen fluoride/hydrofluoric acid – 06/01/10pdf icon [PDF – 2,552 KB]
• A-04 Dinitrotoluene (CAS # 25321–14–6); 2,4–; (CAS # 121–14–2); 2,6–; (CAS # 606–20–2): Submission to the docket from peer reviewers on Dinitrotoluene – 06/01/10pdf icon [PDF – 4,410 KB]
• A-05 Acrylamide (CAS # 79–06–1): Submission to the docket from peer reviewers on Acrylamide – 06/01/10pdf icon [PDF – 1,516 KB]
• A-06 Acrylonitrile (CAS # 107–13–1): Submission to the docket from peer reviewers on Acrylonitrile – 06/01/10pdf icon [PDF – 1,673 KB]
• A-07 Metallic Chromium and other Substances containing Hexavalent Chromium [Cr(VI)] CAS # 7440–47–3; 18540–29–9: Submission to the docket from peer reviewers on Metallic Chromium and other Substances containing Hexavalent Chromium (Cr(VI)) – 06/01/10pdf icon [PDF – 3,095 KB]
• A-08 m,p,o-Dinitrobenzene (CAS # 99–65–0; 58–29–0; 100–25–4): Submission to the docket from peer reviewers on m,p,o-Dinitrobenzene – 06/01/10pdf icon [PDF – 2,327 KB]
• A-09 Epichlorohydrin (CAS # 106–89–8): Submission to the docket from peer reviewers on Epichlorohydrin – 06/01/10pdf icon [PDF – 1,971 KB]
• A-10 Ethylene glycol dinitrate (CAS # 628–96–6): Submission to the docket from peer reviewers on Ethylene glycol dinitrate – 06/01/10pdf icon [PDF – 2,642 KB]
• A-11 Bisphenol A (CAS # 80–05–7): Submission to the docket from peer reviewers on Bisphenol A – 06/01/10pdf icon [PDF – 2,428 KB]
• A-12 Formaldehyde (CAS # 50–00–0): Submission to the docket from peer reviewers on Formaldehyde – 06/01/10pdf icon [PDF – 3,426 KB]
• A-13 Hydrazine (CAS # 302–01–2): Submission to the docket from peer reviewers on Hydrazine – 06/01/10pdf icon [PDF – 2,343 KB]
• A-14 Nitroglycerin (CAS # 55–63–0): Submission to the docket from peer reviewers on Nitroglycerin – 06/01/10pdf icon [PDF – 2,461 KB]
• A-15 Nonane (CAS # 111–84–2): Submission to the docket from peer reviewers on Nonane – 06/01/10pdf icon [PDF – 1,937 KB]
• A-16 Glutaraldehyde (CAS # 111–30–8): Submission to the docket from peer reviewers on Glutaraldehyde – 06/01/10pdf icon [PDF – 2,556 KB]
• A-17 Sodium hydroxide (CAS # 1310–73–2): Submission to the docket from peer reviewers on Sodium hydroxide – 06/01/10pdf icon [PDF – 2,354 KB]
• A-18 Trichloroethylene (CAS # 79–01–6): Submission to the docket from peer reviewers on Trichloroethylene – 06/01/10pdf icon [PDF – 3,277 KB]
• A-19 Methyl cellosolve (CAS # 109–86–4): Submission to the docket from peer reviewers on Methyl cellosolve – 06/01/10pdf icon [PDF – 2,958 KB]
• A-20 2-Butoxyethanol (CAS # 111–76–2): Submission to the docket from peer reviewers on 2-Butoxyethanol – 06/01/10pdf icon [PDF – 2,619 KB]
• A-21 2-Ethoxyethanol (CAS # 110–80–5): Submission to the docket from peer reviewers on 2-Ethoxyethanol – 06/01/10pdf icon [PDF – 2,055 KB]
• A-22 p-Phenylenediamine (CAS # 106–50–3): Submission to the docket from peer reviewers on p-Phenylenediamine – 06/01/10pdf icon [PDF – 1,920 KB]

Submissions in Numerical Order

Submission to Docket Office from Kristy Morrison (American Chemistry Council) on A-03; 06/11/10pdf icon [PDF – 2,153 KB]

Submission to Docket Office from Markku Huvienen and Grant Darrie (International Chromium Development Association) on A-07; 05/12/10pdf icon [PDF – 2,941 KB]

Submission to Docket Office from John Wittenborn (Counsel to the Specialty Steel Industry of North American) on A-07; 06/10/10pdf icon [PDF – 2,443 KB]

Submission to Docket Office from Paul Dugard (Halogenated Solvents Industry Alliance Inc) on A-18; w/3 attachments; 06/11/10pdf icon [PDF – 1,922 KB]

Attachment 1-HLA-B*1301 as a Biomarker for Genetic Susceptibility to Hypersensitivity Dermatitis Induced by Trichloroethylene among Workers in China;11/01/07pdf icon [PDF – 5,507 KB]

Attachment 2-Hepatitis, Rash and Eosinophilia Following Trichloroethylene Exposure: A Case Report and Speculation on Mechanistic Similarity to Halothane Induced Hepatitis;01/01/96pdf icon [PDF – 5,946 KB]

Attachment 3-Occupational Trichloroethylene Exposure as a Cause of Idiosyncratic Generalized Skin Disorders and Accompanying Hepatitis Similar to Drug Hypersensitivities;01/01/0pdf icon [PDF – 16,005 KB]