Cholesterol Reference Method Laboratory Network

The Cholesterol Reference Method Laboratory Network (CRMLN) is a network of highly specialized laboratories that work directly with manufacturers and laboratories to assess the analytical accuracy and precision of their tests. CRMLN provides reference measurement services to laboratories for measuring total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and total glycerides (TG). CRMLN laboratories have to meet stringent analytical performance criteria to ensure their measurements are sufficiently accurate and precise for evaluating these tests.

Network laboratories assess tests produced by manufacturers and laboratories for their analytical accuracy and precision. Tests and laboratories meeting established criteria for accuracy and precision are considered “CDC-certified,” and sufficiently accurate and precise for use in patient care. Lists of the clinical diagnostic products that have been certified through this process are updated regularly.

The Food and Drug Administration (FDA) has recognized the value of CDC’s Standardization Programs and work performed through CRMLN, and encourages manufacturers to be standardized to CDC.


Use of trade names is for identification only and does not constitute endorsement by the CDC or the U.S. Department of Health and Human Services.