At a glance
CDC works with the U.S. Food and Drug Administration (FDA); state, territorial, and local health departments; and Human Cells, Tissues, or Cellular or Tissue-based Products (HCT/P) establishments to help ensure the safety of the HCT/P supply.
What to know
On May 20, 2024, the FDA withdrew the “Guidance for Industry, Donor Screening Recommendations to Reduce the Risk of Transmission of Zika Virus by Human Cells, Tissues, and Cellular and Tissue-Based Products (Updated May 2018).” Please access the following website for further information regarding withdrawal: Information for Human Cell, Tissue, and Cellular and Tissue-Based Product (HCT/P) Establishments Regarding FDA's Determination that Zika Virus is no Longer a Relevant Communicable Disease Agent or Disease | FDA.
To access archived HCT/P donor screening information used prior to the date of withdrawal, please access these websites:
- Benjamin I, Fernandez G, Figueira JV, et al. Zika virus detected in amniotic fluid and umbilical cord blood in an in vitro fertilization-conceived pregnancy in Venezuela. Fertil Steril 2017;107(6):1319-1322.
- Bhatnagar J, Rabeneck DB, Martines RB, et al. Zika Virus RNA Replication and Persistence in Brain and Placental Tissue. Emerg Infect Dis. Mar 2017;23(3):405-414. doi:10.3201/eid2303.161499
- Reagan-Steiner S, Simeone R, Simon E, et al. Evaluation of Placental and Fetal Tissue Specimens for Zika Virus Infection - 50 States and District of Columbia, January-December, 2016. MMWR Morb Mortal Wkly Rep. Jun 23 2017;66(24):636-643. doi:10.15585/mmwr.mm6624a3
- Hall V, Walker WL, Lindsey NP, et al. Update: Noncongenital Zika Virus Disease Cases - 50 U.S. States and the District of Columbia, 2016. MMWR Morb Mortal Wkly Rep. Mar 9 2018;67(9):265-269. doi:10.15585/mmwr.mm6709a1
- El Costa H, Gouilly J, Mansuy JM, et al. ZIKA virus reveals broad tissue and cell tropism during the first trimester of pregnancy. Sci Rep. Oct 19 2016;6:35296. doi:10.1038/srep35296
- Garcia-Bujalance S, Gutierrez-Arroyo A, De la Calle F, et al. Persistence and infectivity of Zika virus in semen after returning from endemic areas: Report of 5 cases. J Clin Virol. Nov 2017;96:110-115. doi:10.1016/j.jcv.2017.10.006