Vaccine and Immune Globulin Availability

Current Situation
Updated: February 25, 2020

Currently, there is not a shortage of rabies vaccines or rabies immune globulin products in the U.S.

Rabies Vaccine

  • RabAvertexternal icon rabies vaccine (produced by GlaxoSmithKline [GSK]) is now available following a shortage in 2019. GSK currently has no ordering restrictions for RabAvert.
  • IMOVAXexternal icon rabies vaccine (produced by Sanofi Pasteur) is now available, following a shortage in 2019.  IMOVAX is available from wholesalers, distributors, and directly from the manufacturer. Call Sanofi Pasteur at 1-800-VACCINE if IMOVAX is not available from your wholesaler or distributor.

Human Rabies Immune Globulin

  • KEDRABexternal icon (produced by Kedrion Biopharma) is available with no restrictions.
  • HyperRabexternal icon (produced by Grifols) is available with no restrictions. (HyperRab® is a more potent version of the previously licensed HyperRab™ S/Dexternal icon and requires a smaller volume to achieve the recommended 20 IU/kg dose.)
  • Imogamexternal icon (produced by Sanofi Pasteur) is now available following a shortage earlier this year. Sanofi Pasteur has no ordering restrictions for Imogam as of February 20, 2020.

*Note: HyperRab®external icon immunoglobulin product has a different concentration compared to all other rabies immunoglobulin products (including the very similarly named HyperRab™external icon S/D) and requires lower volumes to administer the recommended dose of 20 IU/kg. Care should be taken to ensure the correct dose of immunoglobulin is administered to ensure adequate immune response.

Recommended Preventive Measures Unaffected by Supply Restriction
  • Standard rabies exposure prevention messaging should be reinforced.
    • Pets and livestock should be vaccinated against rabies as recommended.
    • When possible, after an exposure, efforts should be made to safely capture the animal involved in the exposure and it should be held for observation (if a cat, dog, or ferret) or tested for rabies.
  • Health providers should consult with local/state public health departments to ensure appropriate use of PEP. See: State and local rabies consultation contacts
  • Persons at increased risk for rabies exposure should take appropriate precautions to avoid exposure and consider rabies pre-exposure prophylaxis according to ACIP recommendations.

Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services.