Key points
- La Crosse virus infection can result in mild febrile illness or severe neurologic disease, including meningitis or encephalitis.
- If you think you or a family member might have La Crosse, talk to your healthcare provider.

Symptoms
Most people infected with La Crosse virus do not have symptoms. For people with symptoms, the time from infected mosquito bite to feeling sick (incubation period) ranges from 5 to 15 days.
Initial symptoms
Initial symptoms can include:
- Fever (usually lasting 2-3 days)
- Headache
- Nausea
- Vomiting
- Fatigue (tiredness)
- Lethargy (reduced activity or alertness)
Severe illness
La Crosse virus can cause severe illness, such as inflammation of the brain (encephalitis).
Symptoms of severe illness include:
- High fever
- Headache
- Neck stiffness
- Stupor
- Disorientation
- Coma
- Seizures
- Muscle weakness
- Vision loss
- Numbness
- Paralysis
Outcome and complications
Recovery time from severe illness varies and some effects can persist over time. These can include recurrent seizures and thinking or behavioral problems.
Most patients recover though death does occur rarely (<1%).
Testing and diagnosis
If you think you or a family member might have La Crosse, talk to your healthcare provider.
Healthcare providers diagnose La Crosse based on:
- Signs and symptoms
- History of living in or traveling to an area where La Crosse virus is known to circulate
- History of possible exposure to the mosquitoes that can spread La Crosse virus
- Laboratory testing
Your healthcare provider can order tests to look for La Crosse virus or other infections that cause similar symptoms.