Sister to Sister

Sister to Sister is a risk-reduction behavioral intervention for sexually active African American women ages 18 and older. Delivered during a routine medical visit, Sister to Sister aims to enhance women’s knowledge, beliefs, confidence, and skills to help reduce their risk for sexually transmitted diseases (STDs), especially HIV.

About Sister to Sister

Sister to Sister is a brief (20-minute), one-on-one, skill-based HIV/sexually transmitted disease (STD) risk reduction behavioral intervention that is highly structured and is implemented in primary health care settings by nurses, health educators, or other professional clinic staff using a scripted teaching guide. It is educational, engaging, and gender-appropriate; it uses videos, brainstorming, demonstrations, and skills-building activities. It is designed to be easily integrated into the health care provider’s standard clinical practice. As such, Sister to Sister is an effective tool for addressing the needs of both patients and providers in primary health care settings.

Intervention Goals

  • To provide intensive, culturally sensitive health information to empower and educate women in a clinical setting.
  • To help women understand the various behaviors that put them at risk for HIV and other STDs.
  • To enhance women’s knowledge, beliefs, motivation, confidence, and skills to help them make behavioral changes that will reduce their risk for STDs, especially HIV.

Intervention Core Elements

  • Bolster outcome expectancies regarding condom use.
  • Teach, demonstrate, and practice negotiation and refusal skills.
  • Condom use demonstration.
  • Build self-efficacy to empower the women to want to be safe sexually.

Intervention Population

  • Sexually active women ages 18-45 at high risk for STD and HIV attending primary health care clinics.

Sister to Sister Training

There is no CDC-supported training currently available for Sister to Sister. Technical assistance for the implementation of Sister to Sister is available.

To request technical assistance:

  1. CDC’s directly funded health department and CBO partners may request technical assistance by submitting a request in the CBA Tracking System.
  2. Organizations not directly funded by CDC may contact their local health department for assistance in submitting a request.

If you have questions or need additional assistance, please contact

Implementation and Marketing Materials

The materials and resources listed below support the implementation and/or marketing of Sister to Sister by health departments, community-based organizations, and health care or other organizations. The resources are evidence-based and designed for cost-effective, scalable implementation.

  • Jemmott LS, Jemmott JB, O’Leary A. Effects on sexual risk behavior and STD rate of brief HIV/STD prevention interventions for African American women in primary settings. Am J Public Health 2007;97(6):1034-1040.