Moderna COVID-19 Vaccine Overview and Safety
NOTICE: FDA expanded the use of a booster shot for COVID-19 vaccines in certain populations and authorized a single booster shot for Moderna and the Johnson & Johnson/Janssen vaccine. The Advisory Committee on Immunization Practices is meeting on Thursday, October 21, to discuss its recommendations for COVID-19 booster shots.
Manufacturer: ModernaTX, Inc.
Type of Vaccine: mRNA
Number of Shots: 2 shots, 28 days apart
Some immunocompromised people should get 3 shots.
Booster Shots: At this time, people who got the Moderna vaccine are not eligible for a booster shot. More data on the effectiveness and safety of Moderna booster shots are expected soon. With those data in hand, CDC will keep the public informed with a timely plan for Moderna booster shots.
How Given: Shot in the muscle of the upper arm
Does NOT Contain: Eggs, preservatives, latex, metals
Full List of Ingredients
- The Moderna vaccine is recommended for people aged 18 years and older.
- Learn more about how CDC is making COVID-19 vaccine recommendations.
- If you have had a severe allergic reaction (anaphylaxis) or an immediate allergic reaction, even if it was not severe, to any ingredient in an mRNA COVID-19 vaccine (such as polyethylene glycol), you should not get an mRNA COVID-19 vaccine.
- If you had a severe or immediate allergic reaction after getting the first dose of an mRNA COVID-19 vaccine, you should not get a second dose of either of the mRNA COVID-19 vaccines (Moderna or Pfizer-BioNTech).
- A severe allergic reaction is one that needs to be treated with epinephrine or EpiPen or with medical care. Learn about common side effects of COVID-19 vaccines and when to call a doctor.
- An immediate allergic reaction means a reaction within 4 hours of getting the shot, including symptoms such as hives, swelling, or wheezing (respiratory distress).
If you aren’t able to get an mRNA COVID-19 vaccine, you may still be able to get a different type of COVID-19 vaccine. Get more information for people with allergies.
Possible Side Effects
In the arm where you got the shot:
Throughout the rest of your body:
- Muscle pain
These side effects happen within a day or two of getting the vaccine. They are normal signs that your body is building protection and should go away within a few days.
Learn more about possible side effects after getting a COVID-19 vaccine.
COVID-19 vaccines are not interchangeable. If you received a Pfizer-BioNTech or Moderna COVID-19 vaccine, you should get the same product for your second shot.
Safety Data Summary
- In clinical trials, reactogenicity symptoms (side effects that happen within 7 days of getting vaccinated) were common but were mostly mild to moderate. Few people had reactions that affected their ability to do daily activities.
- Side effects throughout the body (such as fever, chills, tiredness, and headache) were more common after the second dose of the vaccine.
- Cases of myocarditis and pericarditis in adolescents and young adults have been reported more often after getting the second dose than after the first dose of one of the two mRNA COVID-19 vaccines, Pfizer-BioNTech or Moderna. These reports are rare and the known and potential benefits of COVID-19 vaccination outweigh the known and potential risks, including the possible risk of myocarditis or pericarditis.
- CDC will continue to provide updates as we learn more about the safety of the Moderna vaccine in real-world conditions.
Learn more about vaccine safety monitoring after a vaccine is authorized or approved for use.
How Well the Vaccine Works
- Based on evidence from clinical trials, in people aged 18 years and older, the Moderna vaccine was 94.1% effective at preventing laboratory-confirmed COVID-19 infection in people who received two doses and had no evidence of being previously infected.
- The vaccine was also highly effective in clinical trials at preventing COVID-19 among people of diverse age, sex, race, and ethnicity categories and among people with underlying medical conditions.
- CDC will continue to provide updates as we learn more about how well the Moderna vaccine works in real-world conditions.
Clinical trials for the Moderna vaccine included people from the following racial, ethnic, age, and sex categories:
- 79% White
- 10% African American
- 5% Asian
- <3% other races/ethnicities
- <1% American Indian or Alaska Native
- <1% Native Hawaiian or Other Pacific Islander
- 79% not Hispanic or Latino
- 20% Hispanic or Latino
- 1% unknown
- 53% male
- 47% female
- 75% 18 through 64 years
- 25% 65 years and older
Twenty-two (22%) of people who participated in the clinical trials had at least one condition that put them at risk of severe illness from COVID-19. The most frequent underlying medical conditions among participants were lung disease, heart disease, obesity, diabetes, liver disease, or HIV infection. Four percent (4%) of participants had two or more high-risk conditions.
Most people who participated in the trials (82%) were considered to have an occupational risk of exposure, with 25% of them being healthcare workers.