Important update: Healthcare facilities
CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. Learn more
UPDATE
Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the guidance for fully vaccinated people. CDC recommends universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status. Children should return to full-time in-person learning in the fall with layered prevention strategies in place.
UPDATE
The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. For purposes of entry into the United States, vaccines accepted will include FDA approved or authorized and WHO Emergency Use Listing vaccines. More information is available here.
UPDATE
Travel requirements to enter the United States are changing, starting November 8, 2021. More information is available here.

Different COVID-19 Vaccines

Different COVID-19 Vaccines
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Approved or Authorized Vaccines

Below are the vaccines that are approved or authorized in the United States to prevent COVID-19:

Pfizer-BioNTech
Moderna
Johnson & Johnson’s Janssen

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Different COVID-19 Vaccines

COVID-19 vaccines are now widely available for people ages 5 years and older. In most cases, you do not need an appointment. Learn how to find a COVID-19 vaccine so you can get vaccinated as soon as possible.

All currently approved or authorized COVID-19 vaccines are safe and effective and reduce your risk of severe illness. CDC does not recommend one vaccine over another.

Vaccine Brand Name [ 1 ]
Pfizer-BioNTech

Ages Recommended
5+ years old

Primary Series
2 doses
Given 3 weeks (21 days) apart [ 2 ]

Booster Dose
Everyone ages 18 years and older is eligible at least 6 months after the last dose in their primary series. Any of the three COVID-19 vaccines can be used for the booster dose.

When Fully Vaccinated
2 weeks after 2nd dose

Vaccine Brand Name [ 1 ]
Moderna

Ages Recommended
18+ years old

Primary Series
2 doses
Given 4 weeks (28 days) apart [ 2 ]

Booster Dose
Everyone ages 18 years and older is eligible at least 6 months after the last dose in their primary series. Any of the three COVID-19 vaccines can be used for the booster dose.

When Fully Vaccinated
2 weeks after 2nd dose

Vaccine Brand Name [ 1 ]
Johnson & Johnson’s Janssen

Ages Recommended
18+ years old

Primary Series
1 dose

Booster Dose
At least 2 months after first dose in all people ages 18 years and older. Any of the three COVID-19 vaccines can be used for the booster dose.

When Fully Vaccinated
2 weeks after 1st dose

Pfizer-BioNTech [ 1 ]

Moderna [ 1 ]

Johnson & Johnson’s Janssen [ 1 ]

Pfizer-BioNTech [ 1 ]

Ages Recommended
5+ years old

Moderna [ 1 ]

Ages Recommended
18+ years old

Johnson & Johnson’s Janssen [ 1 ]

Ages Recommended
18+ years old

Pfizer-BioNTech [ 1 ]

Primary Series
2 doses
Given 3 weeks (21 days) apart [ 2 ]

Moderna [ 1 ]

Primary Series
2 doses
Given 4 weeks (28 days) apart [ 2 ]

Johnson & Johnson’s Janssen [ 1 ]

Primary Series
1 dose

Pfizer-BioNTech [ 1 ]

Booster Dose
Everyone ages 18 years and older is eligible at least 6 months after the last dose in their primary series. Any of the three COVID-19 vaccines can be used for the booster dose.

Moderna [ 1 ]

Booster Dose
Everyone ages 18 years and older is eligible at least 6 months after the last dose in their primary series. Any of the three COVID-19 vaccines can be used for the booster dose.

Johnson & Johnson’s Janssen [ 1 ]

Booster Dose
At least 2 months after the first dose for all people ages 18 years and older. Any of the three COVID-19 vaccines can be used for the booster dose.

Pfizer-BioNTech [ 1 ]

When Fully Vaccinated
2 weeks after 2nd dose

Moderna [ 1 ]

When Fully Vaccinated
2 weeks after 2nd dose

Johnson & Johnson’s Janssen [ 1 ]

When Fully Vaccinated
2 weeks after 1st dose

1 If you had a severe allergic reaction after a previous dose or if you have a known (diagnosed) allergy to a COVID-19 vaccine ingredient, you should not get that vaccine. If you have been instructed not to get one type of COVID-19 vaccine, you may still be able to get another type. Learn more information for people with allergies.

2 You should get your second shot as close to the recommended 3-week or 4-week interval as possible.

Additional Recommendations for Immunocompromised People

Additional primary dose: Moderately to severely immunocompromised people who are 12 years and older and received a Pfizer-BioNTech primary series or 18 years and older and received a Moderna primary series should receive an additional primary dose of the same vaccine at least 28 days after their second dose.

Booster dose:  Moderately to severely immunocompromised people who are 18 years of age and older and received a Pfizer-BioNTech or Moderna primary series are also eligible for a booster dose at least 6 months after their additional primary dose, using any of the three COVID-19 vaccines.

Immunocompromised people who received a J&J/Janssen vaccine are not recommended to receive an additional primary dose, but should receive a booster dose at least 2 months after their initial dose, using any of the three COVID-19 vaccines.

Vaccine Types and How They Work

  • Understanding How COVID-19 Vaccines Work
    Learn how the body fights infection and how COVID-19 vaccines protect people by producing immunity. Also see the different types of COVID-19 vaccines that currently are available or are undergoing large-scale (Phase 3) clinical trials in the United States.​
  • COVID-19 mRNA Vaccines
    Information about mRNA vaccines generally and COVID-19 vaccines that use this technology.
  • Viral Vector COVID-19 Vaccines
    Information about viral vector vaccines generally and COVID-19 vaccines that use this technology.

Vaccines in Phase 3 Clinical Trials

Large-scale (Phase 3) clinical trials are in progress or being planned for COVID-19 vaccines in the United States. To learn more about U.S. COVID-19 vaccine clinical trials, including vaccines in earlier stages of development, by visiting clinicaltrials.gov.external icon

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For Healthcare and Public Health

COVID-19 Clinical and Professional Resources