SARS-CoV-2 Variants
SARS-CoV-2 Variants
Name (Pangolin) |
Name (Nextstrain) |
First Detected | Cases in the US |
Countries Reporting Cases |
Key Mutations | Transmissibility Rate |
---|---|---|---|---|---|---|
B.1.1.7 | 20I/501Y.V1 | United Kingdom | Y | 70 |
|
~50% increase 14,15 |
P.1 | 20J/501Y.V3 | Japan/ Brazil |
Y | >4 |
|
Not determined |
B.1.351 | 20H/501.V2 | South Africa | Y | >30 |
|
Not determined |
Last Updated: Jan 27, 2021
References
- Horby P, Huntley C, Davies N et al. NERVTAG note on B.1.1.7 severity. New & Emerging Threats Advisory Group, Jan. 21, 2021. Retrieved from NERVTAG note on variant severityexternal icon.
- Public Health England. Investigation of novel SARS-CoV-2 variant: Variant of Concern 202012/01.202012/01. Technical briefing 3. 28 Dec 2020. Retrieved from Investigation of novel SARS-CoV-2 Variant: Variant of Concern 202012/01pdf iconexternal icon.
- *Tegally H, Wilkinson E, Giovanetti M, et al. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa. MedRxiv 2020. doi: https://doi.org/10.1101/2020.12.21.20248640external icon.
- *Wu K, Werner AP, Moliva JI, et al. MRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants. BioRxiv 2021. doi: https://doi.org/10.1101/2021.01.25.427948external icon.
- National Institute of Infectious Diseases, Japan. (2021, January 12.) Brief report: New Variant Strain of SARS-CoV-2 Identified in Travelers from Brazil [Press release]. Retrieved from https://www.niid.go.jp/niid/en/2019-ncov-e/10108-covid19-33-en.htmlexternal icon.
- MN Department of Health. (2021, January 25). MDH lab testing confirms nation’s first known COVID-19 case associate with Brazil P.1 variant [Press release]. Retrieved from News release: MDH lab testing confirms nation’s first known COVID-19 case associated with Brazil P.1 variant (state.mn.us)external icon.
- *Faria NR, Claro IM, Candido D, et al. Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings. 12 Jan 2021. Retrieved from Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings – SARS-CoV-2 coronavirus / nCoV-2019 Genomic Epidemiologyexternal icon – Virological.
- *Resende PC, Bezerra JF, de Vasconcelos RHT, et al. Spike E484K mutation in the first SARS-CoV-2 reinfection case confirmed in Brazil, 2020. 10 Jan 2021. Retrieved from Spike E484K mutation in the first SARS-CoV-2 reinfection case confirmed in Brazil, 2020 – SARS-CoV-2 coronavirus / nCoV-2019 Genomic Epidemiology – Virologicalexternal icon.
- *Naveca F, de Costa C, Nascimento V, et al. SARS-CoV-2 reinfection by the new Variant of Concern (VOC) P.1 in Amazonas, Brazil. Retrieved from SARS-CoV-2 reinfection by the new Variant of Concern (VOC) P.1 in Amazonas, Brazil – SARS-CoV-2 coronavirus / nCoV-2019 Genomic Epidemiology – Virologicalexternal icon.
- *Bin Zhou, Tran Thi Nhu Thao, Donata Hoffmann, et al. SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility bioRxiv 2020.10.27 doi: https://doi.org/10.1101/2020.10.27.357558external icon.
- Volz E, Hill V, McCrone J, et al. Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity. Cell 2021; 184(64-75). doi: https://doi.org/10.1016/j.cell.2020.11.020external icon.
- Korber B, Fischer WM, Gnanakaran S, et al. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell 2021; 182(812-7). doi: https://doi.org/10.1016/j.cell.2020.06.043external icon.
- Yurkovetskiy L, Wang X, Pascal KE, et al. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell 2020; 183(3): 739-1. doi: https://doi.org/10.1016/j.cell.2020.09.032external icon.
- *McCarthy KR, Rennick LJ, Namnulli S, et al. Natural deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape. bioRxiv [Preprint posted online November 19, 2020] https://www.biorxiv.org/content/10.1101/2020.11.19.389916v1external icon.
- *Kemp SA, Harvey WT, Datir RP, et al. Recurrent emergence and transmission of a SARS-CoV-2 spike deletion ΔH69/V70. bioRxiv [Preprint posted online January 14, 2021] https://www.biorxiv.org/content/10.1101/2020.12.14.422555v4external icon .
*Non-peer-reviewed