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Isophorone

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Synonyms & Trade Names
Isoacetophorone, 3,5,5-Trimethyl-2-cyclohexenone, 3,5,5-Trimethyl-2-cyclo-hexen-1-one
CAS No.
78-59-1
RTECS No.
GW7700000
DOT ID & Guide
1993 128(combustible liquid, n.o.s.)
Formula
C₉H₁₄O
Conversion
1 ppm = 5.65 mg/m3
IDLH
200 ppm
See: 78591
Exposure Limits
NIOSH REL
TWA 4 ppm (23 mg/m3)
OSHA PEL
TWA 25 ppm (140 mg/m3) See Appendix G
Measurement Methods
NIOSH 2508 , 2556;
OSHA 7
See: NMAM or OSHA Methods
Physical Description
Colorless to white liquid with a peppermint-like odor.
Molecular Weight
138.2
Boiling Point
419°F
Freezing Point
17°F
Solubility
1%
Vapor Pressure
0.3 mmHg
Ionization Potential
9.07 eV
Specific Gravity
0.92
Flash Point
184°F
Upper Explosive Limit
3.8%
Lower Explosive Limit
0.8%
Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.
Incompatibilities & Reactivities
Oxidizers, strong alkalis, amines
Exposure Routes
inhalation, ingestion, skin and/or eye contact
Symptoms
irritation eyes, nose, throat; headache, nausea, dizziness, lassitude (weakness, exhaustion), malaise (vague feeling of discomfort), narcosis; dermatitis; In Animals: kidney, liver damage
Target Organs
Eyes, skin, respiratory system, central nervous system, liver, kidneys
Personal Protection/Sanitation
(See protection codes)
Skin:Prevent skin contact
Eyes:Prevent eye contact
Wash skin:When contaminated
Remove:When wet or contaminated
Change:No recommendation
Provide:Eyewash
First Aid
(See procedures)
Eye:Irrigate immediately
Skin:Soap wash promptly
Breathing:Respiratory support
Swallow:Medical attention immediately
Respirator Recommendations

NIOSH

Up to 40 ppm:
(APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)*
(APF = 10) Any supplied-air respirator*

Up to 100 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*
(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)*

Up to 200 ppm:
(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)*
(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode*
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece

Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus

Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
Any appropriate escape-type, self-contained breathing apparatus

Important additional information about respirator selection

See also
INTRODUCTION   ICSC CARD: 0169   MEDICAL TESTS: 0123
Page last reviewed: October 30, 2019
Content source: National Institute for Occupational Safety and Health