U.S. Case Data: Monkeypox

Data reported to CDC as of October 1, 2026
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What to know

U.S. monkeypox case trends data will be updated the first week of every month. Clade II monkeypox is still circulating at low levels. Imported clade I cases in the United States increased in frequency beginning in March 2026, and local transmission has been occurring since August 2026, indicating a likely transition to sustained clade Ib transmission in the United States. CDC recommends two doses of JYNNEOS to provide maximum protection against both clades of monkeypox.

Trends of monkeypox cases reported to CDC by date*^

*Date is defined as the earliest date available regarding the case (i.e., date of illness onset, diagnosis date, positive laboratory test report date, or date reported to CDC).

Case counts include those who tested positive for either monkeypox virus or orthopoxvirus as described in the case definition.

^ Includes all monkeypox cases (clade I and clade II) reported to CDC.

2024-2026 cases counts are preliminary and subject to change. Data for most recent month may be incomplete due to reporting delays and should be interpreted with caution.

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National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
About This Page
Published: September 16, 2024
Updated: October 8, 2026

This page was last updated on this date. Updates may include minor edits, image changes, or other modifications to page content.

Reviewed: October 8, 2026

The information on this page was last reviewed by subject matter experts to ensure accuracy.