PHIN Guides

At a glance

The guides presented here provide format and content specifications for public health information exchange. Their use supports seamless interchange of information among healthcare, public health and other partners.

Technical resources

Guides by Topic

Document Transaction Standard(s) Used Status

HL7®Version 2.5.1 Implementation Guide:Electronic Laboratory Reporting to Public Health (US Realm), Release 2, HL7®Informative Document (May 2014)

(HL7®account required)

Electronic Laboratory Reporting to Public Health HL7®2.5.1 Published

CDC’s National Healthcare Safety Network (NHSN) supports Clinical Document Architecture (CDA) import of certain healthcare-associated infection (HAI) data. Please visit the NHSN CDA Submission Support Portal for the implementation guide, toolkits, training videos, and other resources.

Please visit the National Notifiable Diseases Surveillance System (NNDSS) Technical Resource Center at There, you can access finalized NNDSS HL7®Message Mapping Guides (MMGs), HL7®MMGs in development, MMG-related artifacts, and an archive of historical documentation.

CDC, in collaboration with the International Society for Disease Surveillance, has developed and published syndromic surveillance messaging guides. These guides support Promoting Interoperability programs that employ health information technology to improve the quality and value of American healthcare. To access and use the HL7®implementation guides for the Syndromic Surveillance Promoting Interoperability objectives, please see the table below.

Syndromic Surveillance
Location Transaction Standard(s) Used Status
Syndromic Surveillance Message Mapping Guides Syndromic surveillance transmissions from healthcare providers to public health

HL7®Version 2.5.1,




Rx Norm,



The following decisions were made by the ISDS Message Guide Workgroup as well as the changes to streamline and reduce redundancies from previous versions of the guide:

  • Removed all references to laboratory data
  • Removed all ICD 9 references
  • Removed all references to HL7®v2.3.1