NIOSH Skin Notation Profile: Diacetyl and 2,3-Pentanedione

This Skin Notation Profile provides the SK assignments and supportive data for Diacetyl and 2,3-Pentanedione. In particular, this document evaluates and summarizes the literature describing the hazard potential of the substance and its assessment according to the scientific rationale and framework outlined in Current Intelligence Bulletin 61. In meeting this objective, this Skin Notation Profile intends to inform the audience—mostly occupational health practitioners, researchers, policy- and decision-makers, employers, and workers in potentially hazardous workplaces—so that improved risk-management practices may be developed to better protect workers from the risks of skin contact with the chemicals of interest.