Chronic Diseases, Conditions, or Surgical Procedures

Bone fractures (n = 515, 16%), anxiety (n=377, 12%), iron deficiency anemia (n=363, 12%), hypertension (n=333, 11%), and depression (n=329, 10%) accounted for the five most common non-bleeding disorder diseases or conditions ever experienced among the Registry participants (Table 6).

Table 6: Number and percent of selected chronic diseases, conditions, or surgical procedures ever experienced among the Registry participants, 2014

Number and percent of selected chronic diseases, conditions, or surgical procedures ever experienced among the Registry participants
Diagnosis Total = 3,161  (%)
Cancer
Hepatocellular carcinoma (HCC) * *
Leukemia (any type) 6 (<1)
Cancer other than HCC and leukemia 82 (3)
Bone Disease
Fracture of a bone 515   (16)
Osteopenia 68 (2)
Osteoporosis 44 (1)
Cardiovascular Disease
Acute ischemic stroke 16 (<1)
Atrial fibrillation 22  (1)
Coronary artery disease 38 (1)
Congestive heart failure 11 (<1)
Myocardial infarction 8 (<1)
Transient ischemic attack 14 (<1)
Kidney Disease
Chronic kidney disease 22 (1)
Kidney stones 151 (5)
Nephrotic syndrome 11 (<1)
Liver Disease
Ascites 17 (1)
Cirrhosis 67 (2)
Hepatic fibrosis 70 (2)
Splenomegaly 47 (2)
Varices (esophageal or gastric) 37 (1)
Thrombosis
Deep vein thrombosis 30 (1)
Pulmonary embolism 7 (<1)
Other
Anxiety 377 (12)
Depression 329 (10)
Diabetes mellitus 118 (4)
Hypertension 333 (11)
Iron deficiency anemia 363 (12)
Pseudotumor 27 (1)
Surgical Procedure
Coronary angioplasty or stent placement 20 (1)
Coronary artery bypass graft 14 (<1)
Dialysis (peritoneal or hemodialysis) 6 (<1)
Heart valve replacement or repair 10 (<1)
Kidney transplant * *
Liver transplant * *
Peripheral revascularization 6 (<1)

* Counts greater than zero but less than five have been suppressed to protect patient confidentiality.

More female participants in the Registry reported iron deficiency anemia (28% versus 8%), depression (18% versus 9%), and anxiety (18% versus 11%) than male participants (Figure 8A).

Figure 8A: History of selected diseases or conditions among the Registry participants by sex, 2014

Bar chart showing History of selected diseases or conditions among the Registry participants by sex, see details below

Figure 8A: History of selected diseases or conditions among the Registry participants by sex, 2014
Disease or condition Female Male
N % N %
Iron deficiency anemia 152 28% 211 8%
Hypertension 55 10% 278 11%
Depression 98 18% 231 9%
Anxiety 99 18% 278 11%
Fracture of a bone 81 15% 434 17%

Fifty-six percent of participants ages 45 and older reported a history of bone fractures.  A history of anxiety or depression was higher in the 45-64 year age group compared to other age groups.  Over 90% of hypertension was reported by the older age groups. Iron deficiency anemia was similarly reported across age groups (Figure 8B).

Figure 8B:  History of selected diseases or conditions among the Registry participants by age, 2014

Bar chart showing History of selected diseases or conditions among the Registry participants by age, see details below

Figure 8B:  History of selected diseases or conditions among the Registry participants by age, 2014
Disease or condition 20-44 45-64 65+
N % N % N %
Iron deficiency anemia 100 10% 99 21% 24 19%
Hypertension 81 8% 179 38% 66 51%
Depression 193 20% 139 30% 25 19%
Anxiety 175 18% 109 23% 22 17%
Fracture of a bone 183 19% 126 27% 37 29%