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Surveillance for Cancer Incidence and Mortality — United States, 2012





Simple D. Singh, MD1; S. Jane Henley, MSPH1; A. Blythe Ryerson, PhD1 (View author affiliations)

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Preface

This report provides, in tabular and graphic form, official federal statistics on the occurrence of cancer for 2012 and trends for 1999–2012 as reported by CDC and the National Cancer Institute (NCI) (1). Cancer incidence data are from population-based cancer registries that participate in CDC’s National Program of Cancer Registries (NPCR) and NCI’s Surveillance, Epidemiology, and End Results (SEER) program reported as of November 2014. Cancer mortality data are from death certificate information reported to state vital statistics offices through 2012 and compiled into a national file for the entire United States by CDC’s National Center for Health Statistics’ (NCHS) National Vital Statistics System (NVSS). This report is a part of the Summary of Notifiable Noninfectious Conditions and Disease Outbreaks — United States, which encompasses various surveillance years but is being published in 2016 (2). The Summary of Notifiable Noninfectious Conditions and Disease Outbreaks appears in the same volume of MMWR as the annual Summary of Notifiable Infectious Diseases (3).

This report presents information on new cancer cases and deaths for 2012. The number and rate of cancer cases and deaths are stratified by the primary cancer sites as reported for 2012; information is provided by demographic characteristic (e.g., sex, age, race, and ethnicity) and primary cancer site (68 selected sites among men and 72 selected sites among women). Age-adjusted cancer incidence and death rates are shown by primary site and year for the period 1999–2012. Age-adjusted cancer incidence and death rates for the most common sites are shown by race, sex, and ethnicity for 2012, the most recent year for which incidence data are available. Maps of the United States display age-adjusted cancer incidence and death rates, presented by quartiles, for 2012. Time trends in age-adjusted cancer incidence and death rates during 1999–2012 are shown by race, sex, and ethnicity for all sites combined, colorectal, lung and bronchus, prostate, and female breast.

Background

Cancer comprises a diverse mix of diseases occurring in every part of the body and is a leading cause of death in the United States (4). More than half of cancer cases could be prevented (5). Surveillance of cancer incidence and mortality can help public health officials target areas for control efforts (6) and track progress toward meeting the national health objectives set forth in Healthy People 2020 (7). Cancer is a reportable disease in every state and thus all hospitals, physicians’ offices, pathology laboratories, and other medical facilities are required to submit data on all reportable cancer diagnoses to a central cancer registry at the state or territorial level. A cancer registry is a database that contains individual records of all reportable cancer cases in a defined population and includes patient demographics, tumor characteristics (e.g., cancer site and pathology), and information about the notifying health provider or facility. In 1992, Congress established NPCR by enacting the Cancer Registries Amendment Act (Public Law 102-515) (8). Administered by CDC, NPCR collects data on the occurrence of cancer and the type, extent, and location of the cancer. Before NPCR was established, 10 states had no registry, and most states with registries lacked the resources and state legislation needed to gather complete data (9). Presently, NPCR supports central cancer registries in 45 states, the District of Columbia (DC), Puerto Rico, and the U.S. Pacific Island Jurisdictions. NPCR data represent 96% of the overall U.S. population. Together, NPCR and NCI’s SEER Program collect data for the entire U.S. population. Cancer control planners and others can identify variations in cancer rates by population subgroups and monitor trends over time to guide the planning and evaluation of cancer prevention and control programs and allocation of health resources.

Data Sources

Data about cancer incidence and mortality in the Summary of Notifiable Noninfectious Conditions and Disease Outbreaks come from the official federal statistics on cancer, the U.S. Cancer Statistics (USCS) dataset (1). The USCS dataset includes cancer incidence data from NPCR registries in 45 states and DC (cancer incidence data from Puerto Rico and the U.S. Pacific Island Jurisdictions were not available for this analysis) and from SEER program registries in the remaining five states (Connecticut, Hawaii, Iowa, New Mexico, and Utah) and cancer mortality data from NVSS.

Incidence Data

The primary source of data on cancer incidence is medical records. Staff at health care facilities abstract data from patients’ medical records, enter it into the facility’s own cancer registry if it has one, and then send the data to the regional or state registry. Both NPCR and SEER registries collect data using uniform data items and codes as documented by the North American Association of Central Cancer Registries (NAACCR). This uniformity ensures that data items collected by the two federal programs are comparable (10,11). Information on primary site and histology is coded according to the International Classification of Diseases for Oncology, Third Edition (ICD-O-3) and categorized according to the revised SEER recodes dated January 27, 2003, which define standard groupings of primary cancer sites (http://seer.cancer.gov/siterecode) (12). Beginning with 2010 diagnoses, cases were first classified by anatomic site using ICD-O-3; cases with hematopoetic histologies were further classified by using the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (13). Data from the NPCR registries provided in this report were reported to CDC as of November 30, 2014. Data from SEER registries were reported to NCI as of November 1, 2014.

NPCR and SEER cancer registries consider as reportable all incident cases with a behavior code of 2 (in situ, noninvasive) or 3 (malignant, primary site only) in ICD-O-3. Exceptions include in situ cancer of the cervix and all basal and squamous cell carcinomas of the skin, except for those on the skin of the genital organs (12). Beginning with 2001 diagnoses, several cancers that are coded as malignant in ICD-O-3 were not coded as malignant in ICD-O-2 (10). Additional information is provided in the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IncidenceDataSources).

Mortality Data

Cancer mortality statistics are based on information from all death certificates filed in the 50 states and DC and processed by NVSS at NCHS (14). The cancer mortality data were compiled in accordance with World Health Organization regulations, which specify that member nations classify and code causes of death in accordance with the current revision of the International Classification of Diseases (ICD) (15). For consistency with the data on cancer incidence, the cancer sites in mortality data were grouped according to the revised SEER recodes dated January 27, 2003 (available at http://seer.cancer.gov/codrecode). Data for a specific calendar year are based on records of deaths that occurred during that calendar year and received by a particular date; for example, mortality data for 2012 are based on records of deaths that occurred during 2012 and were received as of June 30, 2014. Additional information is provided in the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=MortalityDataSources).

Population Estimates

Population denominators are race-specific, ethnicity-specific, and sex-specific county population estimates from the U.S. Census, modified by SEER and aggregated to the state and national level. Additional details about population data are available at http://seer.cancer.gov/popdata/index.html.

Interpreting Data

Incidence Data

Each year, state cancer registries submit cancer cases for a new diagnosis year and an updated version of the previous years’ cancer cases to CDC or NCI. Therefore, each year, when USCS data are published, updates to the previous year’s data are published, using the most recent data submission and the most recent population data. Users of cancer incidence data published by federal agencies should be mindful of the data submission dates for all data used in their analyses.

Mortality Data

Cancer mortality statistics in USCS are influenced by the accuracy of information on the death certificate. Unlike incidence data, mortality data for a calendar year are considered complete when submitted and so are not updated after the aggregate data file is released. Mortality data for the entire United States refer only to deaths that occurred within the United States; data for geographic areas are provided by the decedent’s place of residence.

Race and Ethnicity Data

For cancer incidence, race and ethnicity data are abstracted from medical records and grouped into categories (11). When cancer mortality is reported, race and ethnic origin are recorded separately on the death certificate by the funeral director as provided by an informant or, in the absence of an informant, on the basis of observation (16).

Differences in rates among racial and ethnic populations should be interpreted with caution. A study using SEER incidence data suggests that the quality of data on race in cancer registries is considered excellent for whites, blacks, and Asians/Pacific Islanders, good for Hispanics, and poor for American Indians/Alaska Natives (17). Previous studies involving cancer mortality data demonstrate that death rates for whites and blacks generally are estimated accurately whereas death rates for Asians/Pacific Islanders, American Indians/Alaska Natives, and Hispanics are underestimated (18). For this reason, incidence and mortality data provided in this report might be underestimated for these groups, possibly because of misclassification of race or Hispanic ethnicity.

Three NPCR registries (Delaware, Kentucky, and South Carolina) opted not to present state-specific Asian/Pacific Islander counts and rates. Five NPCR registries (Delaware, Kentucky, Massachusetts, Pennsylvania, and South Carolina) opted not to present state-specific Hispanic (classified by the NAACCR Hispanic Identification [NHIA] Algorithm) counts and rates (19). Cancer registries regularly link their database to the Indian Health Service patient registration dataset to reduce misclassification of race for American Indian/Alaska Native cases. Seven NPCR registries (Delaware, Illinois, Kansas, Kentucky, New Jersey, New York, and South Carolina) opted not to present state-specific American Indian/Alaska Native counts and rates. However, in each of these cases, the aggregate national rates presented in this report include data for these registries.

Methods for Identifying Cancer

Medical facilities such as hospitals, doctors’ offices, and pathology laboratories send information about cancer cases to their cancer registry. Most information comes from hospitals, where highly trained cancer registrars transfer the information from the patient’s medical record to the registry’s computer software using standardized codes. The data are then sent to the central cancer registry. Every year the central cancer registries electronically submit incidence, demographic, and clinical data to NPCR or SEER.

Population Coverage

The population coverage for incidence data varies by diagnosis year. Population coverage might be affected by the suppression of state incidence data, if a state did not meet the publication criteria or did not submit data. In addition, state incidence data might be suppressed if <16 cases were reported or if the state requested that the data be suppressed. Additional information is provided by the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=CensusRegionPubCriteria). Mortality data from malignant neoplasms (i.e., cancers) as recorded in the NVSS from the 50 states and DC are available in USCS, and thus 100% of the U.S. population is covered each year. However, state death data might be suppressed if <16 deaths were reported.

Suppression of Rates and Counts

When the numbers of cases or deaths used to compute rates are small, those rates tend to have poor reliability. Therefore, in an effort to discourage misinterpretation or use of rates or counts that are unstable because case or death counts are small, incidence and death rates and counts of <16 are not shown in tables and figures. The use of a threshold value for suppressing cells helps protect the confidentiality of patients by reducing or eliminating the risk for disclosure of their identity. Additional information is provided in the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=Suppression).

Publication Criteria

Cancer incidence data that appear in this report are derived from state cancer registries that have high-quality cancer incidence data for individual (e.g., 2012) and combined (e.g., 1999–2012) years as demonstrated by meeting all of the following criteria on data quality for all cancer sites combined:

  • case ascertainment is ≥90% (margin of error +5%) complete,

  • ≤5% of cases are ascertained solely on the basis of a death certificate,

  • ≤3% of cases are missing information on sex,

  • ≤3% of cases are missing information on age,

  • ≤5% of cases are missing information on race, and

  • ≥97% of the registry’s records passed a set of single-field and inter-field computerized edits that test the validity and logic of data components.

Additional information about USCS is available at http://www.cdc.gov/uscs/.

Highlights

Incidence and Death Rates

In 2012, approximately 1.5 million invasive cancers were diagnosed in the United States, an annual incidence rate of 440 cases per 100,000 persons (Table 1). In the same year, approximately 582,600 persons died of cancer nationally, an annual death rate of 166 deaths per 100,000 persons (Table 2). By state, overall (all cancer sites combined) cancer incidence rates in 2012 ranged from 371 to 515 cases per 100,000 persons (Table 3), and overall cancer death rates ranged from 129 to 201 deaths per 100,000 persons (Table 4).

Cancer incidence (Table 5) and death (Table 6) rates increase with age. In 2012, among persons in the youngest age group (<15 years), 9,967 new cancer cases (rate: 17 cases per 100,000 persons) and 1,367 cancer deaths (rate: two deaths per 100,000 persons) were reported. Among persons aged ≥65 years, 826,841 new cancer cases (rate: 1,933 cases per 100,000 persons) and 403,497 cancer deaths (rate: 935 deaths per 100,000 persons) were reported. Overall, 54% of cancer cases and 69% of cancer deaths in 2012 occurred among persons aged ≥65 years.

Overall and for many cancer sites, males had higher incidence (Table 7) and death rates (Table 8) than did females. In 2012, blacks had the highest cancer incidence (Table 9) and death (Table 10) rates in the United States, and American Indians/Alaska Natives and Asians/Pacific Islanders had the lowest cancer incidence and death rates. Overall and for most cancer sites, Hispanics had lower cancer incidence (Table 11) and death rates (Table 12) than did non-Hispanics. Differences in cancer rates by race and ethnicity (Figure 1) might reflect differences in risk factors, screening, and treatment although rates among some populations might be underestimated because of problems ascertaining race or ethnicity.

By state and site, cancer incidence rates in 2012 ranged from 70 to 157 per 100,000 males for prostate cancer, 107 to 141 per 100,000 females for breast cancer, 4 to 10 per 100,000 females for cervical cancer, 29 to 92 per 100,000 persons for lung cancer, and 30 to 49 per 100,000 persons for colorectal cancer (Figure 2). By state and site, cancer death rates in 2012 ranged from 13 to 32 per 100,000 males for prostate cancer, 16 to 31 per 100,000 females for breast cancer, 1 to 5 per 100,000 females for cervical cancer, 20 to 69 per 100,000 persons for lung cancer, and 11 to 19 per 100,000 persons for colorectal cancer (Figure 3).

Differing rates of cancer by race, ethnicity, and state of residence indicate that for some populations, Healthy People 2020 objectives have already been achieved, whereas objectives for other populations have not been met and these populations might benefit from targeted cancer prevention and control efforts.

Four cancer sites accounted for 49% of all cases diagnosed in 2012, including 224,147 female breast cancers, 210,828 lung and bronchus cancers (111,395 among men and 99,433 among women), 177,489 prostate cancers, and 134,784 colon and rectum cancers (70,204 among men and 64,580 among women) (Table 13). These four sites also accounted for 48% of cancer deaths in 2012, including 157,423 lung cancer deaths, 51,516 colon and rectum cancer deaths, 41,150 female breast cancer deaths, and 27,244 prostate cancer deaths (Table 14).

Time Trends in Incidence and Death Rates

On the basis of data from registries meeting data quality criteria during 1999–2012, cancer incidence rates declined from 484 cancer cases per 100,000 population in 1999 to 434 cases in 2012 (Table 15). Although lung cancer incidence declined steadily among men from 1999 to 2012, it increased among women from 1999 to 2005 and has since declined from 2005 to 2012. Prostate cancer incidence declined from 170 cases per 100,000 men in 1999 to 105 cases in 2012. Colorectal cancer incidence declined from 56 cases per 100,000 persons in 1999 to 39 cases in 2012. Female breast cancer incidence declined from 135 cases per 100,000 women in 1999 to 121 cases in 2005, increased to 125 cases in 2009, and declined again to 122 cases in 2012. Time trends in cancer incidence rates are presented by cancer site, sex, and race (Figure 4) and by cancer site, sex, and ethnicity (Figure 5). During 1999–2012, cancer death rates declined from 201 deaths per 100,000 persons in 1999 to 166 deaths in 2012; during the same period, death rates declined for each of the four most common cancers (Table 16). Time trends in cancer death rates are presented by cancer site, sex, and race (Figure 6) and by cancer site, sex, and ethnicity (Figure 7).

National cancer surveillance data help public health officials track progress toward achieving the national cancer objectives set forth in Healthy People 2020 (20). For the national cancer burden to be reduced and Healthy People 2020 targets to be met, behavioral and environmental factors that increase cancer risk must be reduced, and high-quality screening services, timely follow-up, and evidence-based treatments must be available and accessible to all persons. Several effective primary and secondary prevention measures, such as vaccination against infectious agents that cause cancer (i.e., hepatitis B virus and human papillomavirus), help with smoking cessation, and cancer screening, when effectively implemented and sustained, could reduce the number of new cancer cases and prevent many cancer-related deaths (21). Evidence-based interventions can be implemented at both the individual level and the population level to reduce cancer risk factors, promote healthy living, and encourage cancer screening (5).

Acknowledgments

Data were provided by state and regional cancer registry personnel.


Corresponding author: Simple Singh, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC. Telephone: 770-488-4292; E-mail: sdsingh@cdc.gov.

1Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC

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Return to your place in the textTABLE 1. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site — United States, 2012§
Cancer site All races/ethnicities
No. Rate
All cancer sites combined 1,529,078 440.3
Oral cavity and pharynx 39,879 11.2
Lip 1,842 0.5
Tongue 12,374 3.4
Salivary gland 4,254 1.3
Floor of mouth 1,936 0.5
Gum and other mouth 5,331 1.5
Nasopharynx 1,758 0.5
Tonsil 7,330 2.0
Oropharynx 1,733 0.5
Hypopharynx 2,281 0.6
Other oral cavity and pharynx 1,040 0.3
Digestive system 273,535 78.3
Esophagus 15,993 4.5
Stomach 22,623 6.6
Small intestine 7,894 2.3
Colon and rectum 134,784 38.9
Colon excluding rectum 95,962 27.8
Rectum and rectosigmoid junction 38,822 11.1
Anus, anal canal, and anorectum 6,338 1.8
Liver and Intrahepatic bile duct 28,012 7.7
Gallbladder 3,835 1.1
Other biliary 5,963 1.7
Pancreas 43,213 12.3
Retroperitoneum 1,321 0.4
Peritoneum, omentum, and mesentery 1,924 0.5
Other digestive organs 1,635 0.5
Respiratory system 225,933 64.7
Nose, nasal cavity, and middle ear 2,274 0.7
Larynx 12,152 3.4
Lung and bronchus 210,828 60.4
Pleura 105 0
Trachea, mediastinum, and other respiratory organs 574 0.2
Bones and joints 2,951 0.9
Soft tissue including heart 10,728 3.2
Skin excluding basal and squamous 73,181 21.5
Melanoma of the skin 67,753 19.9
Other nonepithelial skin 5,428 1.6
Male and female breast 226,272 65.6
Female breast 224,147 122.2
Male breast 2,125 1.4
Female genital system 90,303 48.8
Cervix 12,042 7.4
Corpus and uterus, NOS 49,154 25.7
Corpus 47,570 24.9
Uterus, NOS 1,584 0.8
Ovary 20,785 11.3
Vagina 1,296 0.7
Vulva 4,851 2.6
Other female genital organs 2,175 1.2
Male genital system 187,308 111.8
Prostate 177,489 105.3
Testis 8,189 5.5
Penis 1,283 0.8
Other male genital organs 347 0.2
Urinary system 128,103 37.0
Urinary bladder 69,974 20.2
Kidney and renal pelvis 55,231 15.9
Ureter 1,918 0.6
Other urinary organs 980 0.3
Eye and orbit 2,733 0.8
Brain and other nervous system 21,490 6.5
Brain 20,151 6.0
Cranial nerves other nervous system 1,339 0.4
Endocrine system 48,594 15.0
Thyroid 46,279 14.3
Other endocrine including thymus 2,315 0.7
Lymphomas 71,692 21.1
Hodgkin lymphoma 8,273 2.6
Non-Hodgkin lymphoma 63,419 18.5
Myeloma 21,829 6.3
Leukemias 44,396 13.2
Acute lymphocytic leukemia 4,846 1.6
Chronic lymphocytic leukemia 14,821 4.2
Acute myeloid leukemia 13,820 4.1
Chronic myeloid leukemia 5,543 1.7
Other leukemias 5,366 1.6
Mesothelioma 3,199 0.9
Kaposi Sarcoma 1,076 0.3
Miscellaneous 55,876 16.3

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf.

Return to your place in the textTABLE 2. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site — United States, 2012
Cancer site All races/ethnicities
No. Rate
All cancer sites combined 582,607 166.4
Oral cavity and pharynx 8,924 2.5
Lip 71 0
Tongue 2,224 0.6
Salivary gland 869 0.2
Floor of mouth 75 0
Gum and other mouth 1,275 0.4
Nasopharynx 666 0.2
Tonsil 879 0.2
Oropharynx 891 0.2
Hypopharynx 356 0.1
Other oral cavity and pharynx 1,618 0.4
Digestive system 147,024 41.6
Esophagus 14,649 4.1
Stomach 11,191 3.2
Small intestine 1,293 0.4
Colon and rectum 51,516 14.7
Colon excluding rectum 41,867 12.0
Rectum and rectosigmoid junction 9,649 2.7
Anus, anal canal, and anorectum 889 0.3
Liver and intrahepatic bile duct 22,972 6.3
Gallbladder 2,102 0.6
Other biliary 1,519 0.4
Pancreas 38,797 11.0
Retroperitoneum 207 0.1
Peritoneum, omentum, and mesentery 750 0.2
Other digestive organs 1,139 0.3
Respiratory system 161,851 46.2
Nose, nasal cavity, and middle ear 458 0.1
Larynx 3,662 1.0
Lung and bronchus 157,423 45.0
Pleura 82 0
Trachea, mediastinum, and other respiratory organs 226 0.1
Bones and joints 1,399 0.4
Soft tissue including heart 4,559 1.3
Skin excluding basal and squamous 12,463 3.6
Melanoma of the skin 9,251 2.7
Other nonepithelial skin 3,212 0.9
Male and female breast 41,555 11.8
Female breast 41,150 21.3
Male breast 405 0.3
Female genital system 29,405 15.2
Cervix 4,074 2.3
Corpus and uterus, NOS 8,911 4.5
Corpus 3,812 1.9
Uterus, NOS 5,099 2.6
Ovary 14,404 7.4
Vagina 429 0.2
Vulva 1,034 0.5
Other female genital organs 553 0.3
Male genital system 27,955 20.0
Prostate 27,244 19.6
Testis 386 0.3
Penis 273 0.2
Other male genital organs 52 0
Urinary system 29,594 8.5
Urinary bladder 15,245 4.4
Kidney and renal pelvis 13,518 3.8
Ureter 378 0.1
Other urinary organs 453 0.1
Eye and orbit 279 0.1
Brain and other nervous system 15,276 4.4
Endocrine system 2,660 0.8
Thyroid 1,690 0.5
Other endocrine including thymus 970 0.3
Lymphomas 21,518 6.2
Hodgkin lymphoma 1,130 0.3
Non-Hodgkin lymphoma 20,388 5.9
Myeloma 11,821 3.4
Leukemias 23,309 6.8
Acute lymphocytic leukemia 1,408 0.4
Chronic lymphocytic leukemia 4,598 1.3
Acute myeloid leukemia 9,484 2.8
Chronic myeloid leukemia 1,017 0.3
Other leukemias 6,802 2.0
Mesothelioma 2,686 0.8
Miscellaneous 40,276 11.5

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see UCSC technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).

Return to your place in the textTABLE 3. Reported number and age-adjusted rate* of invasive cancer cases, all cancer sites combined, by geographic division and area — United States, 2012§
Area All races/ethnicities
No. Rate
Northeast 311,842 474.3
New England 81,778 469.6
Connecticut 20,371 477.1
Maine 8,417 475.1
Massachusetts 35,774 463.1
New Hampshire 7,576 473.5
Rhode Island 6,095 484.0
Vermont 3,545 449.0
Middle Atlantic 230,064 476.1
New Jersey 48,545 477.7
New York 105,941 475.8
Pennsylvania 75,578 476.1
Midwest 345,611 448.8
East North Central 237,817 446.2
Illinois 64,402 459.0
Indiana 31,852 439.4
Michigan 51,809 444.5
Ohio 59,848 438.0
Wisconsin 29,906 447.7
West North Central 107,794 454.7
Iowa 17,000 463.4
Kansas 14,614 460.3
Minnesota 27,833 462.8
Missouri 31,643 450.6
Nebraska 8,953 432.6
North Dakota 3,577 450.5
South Dakota 4,174 434.3
South 566,112 434.9
South Atlantic 307,360 430.4
Delaware 5,306 483.5
District of Columbia 2,954 474.9
Florida 105,651 414.2
Georgia 45,623 459.6
Maryland 27,870 430.8
North Carolina 48,367 443.0
South Carolina 24,737 447.7
Virginia 35,743 403.1
West Virginia 11,109 461.3
East South Central 100,201 470.0
Alabama 25,225 451.0
Kentucky 25,845 515.1
Mississippi 15,084 457.4
Tennessee 34,047 459.4
West South Central 158,551 424.0
Arkansas 15,259 442.8
Louisiana 24,062 483.4
Oklahoma 18,785 442.8
Texas 100,445 406.2
West
Mountain
Arizona 27,680 373.4
Colorado 21,614 405.5
Idaho 7,452 437.0
Montana 5,424 434.4
Nevada
New Mexico 8,726 371.4
Utah 9,582 404.0
Wyoming 2,516 396.0
Pacific 222,519 418.1
Alaska 2,601 401.8
California 158,944 410.1
Hawaii 6,802 415.6
Oregon 19,531 422.2
Washington 34,641 460.1

*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
Rates and counts are not presented for the West Census Region, the Mountain Census Division, or Nevada because data from Nevada are not included in this analysis.

Return to your place in the textTABLE 4. Reported cancer deaths and age-adjusted death rates,* all cancer sites combined, by geographic division and area — United States, 2012
Area All races/ethnicities
No. Rate
United States 582,607 166.4
Northeast 110,175 164.1
New England 28,904 162.6
Connecticut 6,681 152.0
Maine 3,226 179.0
Massachusetts 12,864 163.3
New Hampshire 2,660 167.7
Rhode Island 2,148 163.6
Vermont 1,325 164.8
Middle Atlantic 81,271 164.7
New Jersey 16,483 160.3
New York 35,881 159.5
Pennsylvania 28,907 174.8
Midwest 135,511 174.1
East North Central 94,939 176.9
Illinois 24,562 175.5
Indiana 13,368 184.2
Michigan 20,496 174.3
Ohio 25,261 182.1
Wisconsin 11,252 166.1
West North Central 40,572 167.8
Iowa 6,438 167.9
Kansas 5,429 167.7
Minnesota 9,424 155.6
Missouri 12,919 182.0
Nebraska 3,479 164.6
North Dakota 1,253 150.7
South Dakota 1,630 162.0
South 221,435 171.4
South Atlantic 118,858 165.8
Delaware 1,935 176.1
District of Columbia 1,081 178.4
Florida 42,187 157.8
Georgia 16,020 169.6
Maryland 10,524 166.0
North Carolina 18,405 170.5
South Carolina 9,728 179.0
Virginia 14,294 165.3
West Virginia 4,684 191.1
East South Central 40,547 192.0
Alabama 10,274 184.8
Kentucky 10,012 201.2
Mississippi 6,496 200.0
Tennessee 13,765 187.9
West South Central 62,030 170.5
Arkansas 6,540 188.6
Louisiana 9,308 190.5
Oklahoma 8,040 189.6
Texas 38,142 160.6
West 115,486 151.9
Mountain 34,819 147.7
Arizona 11,085 148.3
Colorado 7,306 143.7
Idaho 2,572 152.0
Montana 1,954 154.2
Nevada 4,610 163.8
New Mexico 3,461 148.0
Utah 2,876 128.7
Wyoming 955 154.6
Pacific 80,667 153.7
Alaska 925 169.0
California 57,675 151.0
Hawaii 2,284 134.6
Oregon 7,832 168.3
Washington 11,951 161.8

*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).

Return to your place in the textTABLE 5. Reported number and rate* of invasive cancer cases, by primary cancer site and age group — United States, 2012§
Cancer site Age group (yrs) Total
<15 15–24 25–39 40–64 ≥65
No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate (crude)
All cancer sites combined 9,967 16.5 12,634 29 58,709 95.9 620,927 603 826,841 1,932.60 1,529,078 491.5
Oral cavity and pharynx 84 0.1 259 0.6 1,152 1.9 21,140 20.5 17,244 40.3 39,879 12.8
Esophagus 127 0.2 6,383 6.2 9,480 22.2 15,993 5.1
Stomach 649 1.1 8,153 7.9 13,764 32.2 22,623 7.3
Colon and rectum 34 0.1 340 0.8 3,526 5.8 51,746 50.2 79,138 185 134,784 43.3
Liver and intrahepatic bile duct 222 0.4 78 0.2 292 0.5 14,698 14.3 12,722 29.7 28,012 9.0
Pancreas 391 0.6 14,178 13.8 28,585 66.8 43,213 13.9
Larynx 107 0.2 5,966 5.8 6,068 14.2 12,152 3.9
Lung and bronchus 27 0 99 0.2 893 1.5 66,105 64.2 143,704 335.9 210,828 67.8
Melanomas of the skin 107 0.2 897 2.1 5,507 9.0 28,901 28.1 32,341 75.6 67,753 21.8
Female breast 9,605 31.5 114,962 218.7 99,396 411.9 224,147 141.8
Cervix 2,795 9.2 6,730 12.8 2,368 9.8 12,042 7.6
Corpus and uterus, NOS 1,616 5.3 26,341 50.1 21,129 87.6 49,154 31.1
Ovary 102 0.3 348 1.6 1,071 3.5 9,564 18.2 9,700 40.2 20,785 13.2
Prostate 77 0.3 77,236 153.2 100,156 536.9 177,489 115.9
Testis 54 0.2 1,425 6.4 4,073 13.2 2,440 4.8 197 1.1 8,189 5.3
Urinary bladder†† 20 0 65 0.1 548 0.9 18,019 17.5 51,322 120.0 69,974 22.5
Kidney and renal pelvis 527 0.9 180 0.4 1,986 3.2 25,557 24.8 26,981 63.1 55,231 17.8
Brain and nervous system 2,103 3.5 968 2.2 2,084 3.4 8,127 7.9 8,208 19.2 21,490 6.9
Thyroid 197 0.3 2,029 4.7 9,545 15.6 24,876 24.2 9,632 22.5 46,279 14.9
Hodgkin lymphoma 340 0.6 1,599 3.7 2,245 3.7 2,614 2.5 1,475 3.4 8,273 2.7
Non-Hodgkin lymphoma 595 1.0 933 2.1 2,899 4.7 23,101 22.4 35,891 83.9 63,419 20.4
Myeloma 266 0.4 7,887 7.7 13,663 31.9 21,829 7.0
Leukemias 2,948 4.9 1,163 2.7 2,243 3.7 13,517 13.1 24,525 57.3 44,396 14.3
Mesothelioma 36 0.1 666 0.6 2,486 5.8 3,199 1.0
Kaposi Sarcoma 321 0.5 448 0.4 269 0.6 1,076 0.3

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
Counts and rates are suppressed if <16 cases were reported in a specific category. Some counts and rates are suppressed as complementary cell suppression.

Return to your place in the textTABLE 6. Reported number and rate* of cancer deaths, by primary cancer site and age group — United States, 2012
Cancer site Age group (yrs) Total (all ages)
<15 15–24 25–39 40–64 ≥65
No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate (crude)
All cancer sites combined 1,367 2.2 1,574 3.6 7,391 12 168,778 162.5 403,497 935.2 582,607 185.6
Oral cavity and pharynx § 128 0.2 3,677 3.5 5,100 11.8 8,924 2.8
Esophagus 74 0.1 5,358 5.2 9,213 21.4 14,649 4.7
Stomach 271 0.4 3,590 3.5 7,309 16.9 11,191 3.6
Colon and rectum 775 1.3 15,199 14.6 35,480 82.2 51,516 16.4
Liver and intrahepatic bile duct 32 0.1 34 0.1 186 0.3 9,837 9.5 12,883 29.9 22,927 7.3
Pancreas 151 0.2 10,962 10.6 27,676 64.1 38,797 12.4
Larynx 18 0 1,374 1.3 2,269 5.3 3,662 1.2
Lung and bronchus 430 0.7 43,463 41.8 113,499 263.1 157,423 50.2
Melanomas of the skin 300 0.5 3,179 3.1 5,746 13.3 9,251 2.9
Female breast 971 3.2 16,104 30.4 24,062 98.9 41,150 25.8
Cervix 437 1.4 2,259 4.3 1,369 5.6 4,074 2.6
Corpus and uterus, NOS 108 0.4 2,855 5.4 5,944 24.4 8,911 5.6
Ovary 176 0.6 4,822 9.1 9,378 38.6 14,404 9.0
Prostate 2,962 5.8 24,271 128.9 27,244 17.6
Testis 131 0.4 149 0.3 51 0.3 386 0.2
Urinary bladder 35 0.1 2,390 2.3 12,814 29.7 15,245 4.9
Kidney and renal pelvis 30 0 31 0.1 109 0.2 4,134 4.0 9,214 21.4 13,518 4.3
Brain and nervous system 458 0.7 252 0.6 744 1.2 6,177 5.9 7,645 17.7 15,276 4.9
Thyroid 23 0 450 0.4 1,212 2.8 1,690 0.5
Hodgkin lymphoma 134 0.2 353 0.3 604 1.4 1,130 0.4
Non-Hodgkin lymphoma 36 0.1 85 0.2 344 0.6 4,304 4.1 15,619 36.2 20,388 6.5
Myeloma 32 0.1 2,624 2.5 9,164 21.2 11,821 3.8
Leukemias 378 0.6 356 0.8 649 1.1 4,627 4.5 17,299 40.1 23,309 7.4
Mesothelioma 16 0 479 0.5 2,190 5.1 2,686 0.9

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).
§Counts and rates are suppressed if <16 deaths were reported in a specific category. Some counts and rates are suppressed as complementary cell suppression.

Return to your place in the textTABLE 7. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site and sex — United States, 2012§
Cancer site Male Female Total
No. Rate No. Rate No. Rate
All cancer sites combined 767,366 483.0 761,712 411.7 1,529,078 440.3
Oral cavity and pharynx 27,997 16.8 11,882 6.3 39,879 11.2
Lip 1,353 0.9 489 0.3 1,842 0.5
Tongue 8,777 5.2 3,597 1.9 12,374 3.4
Salivary gland 2,404 1.6 1,850 1.0 4,254 1.3
Floor of mouth 1,333 0.8 603 0.3 1,936 0.5
Gum and other mouth 2,915 1.8 2,416 1.3 5,331 1.5
Nasopharynx 1,263 0.8 495 0.3 1,758 0.5
Tonsil 5,977 3.4 1,353 0.7 7,330 2.0
Oropharynx 1,325 0.8 408 0.2 1,733 0.5
Hypopharynx 1,838 1.1 443 0.2 2,281 0.6
Other oral cavity and pharynx 812 0.5 228 0.1 1,040 0.3
Digestive system 151,713 95.6 121,822 63.9 273,535 78.3
Esophagus 12,628 7.8 3,365 1.7 15,993 4.5
Stomach 13,964 9.0 8,659 4.6 22,623 6.6
Small intestine 4,187 2.6 3,707 2.0 7,894 2.3
Colon and rectum 70,204 44.8 64,580 34.1 134,784 38.9
Colon excluding rectum 47,448 30.7 48,514 25.4 95,962 27.8
Rectum and rectosigmoid junction 22,756 14.1 16,066 8.6 38,822 11.1
Anus, anal canal, and anorectum 2,304 1.4 4,034 2.1 6,338 1.8
Liver and Intrahepatic bile duct 20,207 11.8 7,805 4.0 28,012 7.7
Gallbladder 1,221 0.8 2,614 1.4 3,835 1.1
Other biliary 3,246 2.1 2,717 1.4 5,963 1.7
Pancreas 22,101 14.1 21,112 10.9 43,213 12.3
Retroperitoneum 653 0.4 668 0.4 1,321 0.4
Peritoneum, omentum, and mesentery 157 0.1 1,767 0.9 1,924 0.5
Other digestive organs 841 0.5 794 0.4 1,635 0.5
Respiratory system 122,785 78.5 103,148 54.0 225,933 64.7
Nose, nasal cavity, and middle ear 1,376 0.9 898 0.5 2,274 0.7
Larynx 9,565 5.8 2,587 1.3 12,152 3.4
Lung and bronchus 111,395 71.6 99,433 52.1 210,828 60.4
Pleura 60 0 45 0 105 0
Trachea, mediastinum, and other respiratory organs 389 0.3 185 0.1 574 0.2
Bones and joints 1,674 1.1 1,277 0.8 2,951 0.9
Soft tissue including heart 5,881 3.8 4,847 2.8 10,728 3.2
Skin excluding basal and squamous 42,992 27.8 30,189 17.0 73,181 21.5
Melanoma of the skin 39,673 25.5 28,080 15.9 67,753 19.9
Other nonepithelial skin 3,319 2.3 2,109 1.1 5,428 1.6
Male and female breast NA NA NA NA 226,272 65.6
Female breast NA NA 224,147 122.2 NA NA
Male breast 2,125 1.4 NA NA NA NA
Female genital system NA NA 90,303 48.8 NA NA
Cervix NA NA 12,042 7.4 NA NA
Corpus and uterus, NOS NA NA 49,154 25.7 NA NA
Corpus NA NA 47,570 24.9 NA NA
Uterus, NOS NA NA 1,584 0.8 NA NA
Ovary NA NA 20,785 11.3 NA NA
Vagina NA NA 1,296 0.7 NA NA
Vulva NA NA 4,851 2.6 NA NA
Other female genital organs NA NA 2,175 1.2 NA NA
Male genital system 187,308 111.8 NA NA NA NA
Prostate 177,489 105.3 NA NA NA NA
Testis 8,189 5.5 NA NA NA NA
Penis 1,283 0.8 NA NA NA NA
Other male genital organs 347 0.2 NA NA NA NA
Urinary system 89,322 58.0 38,781 20.5 128,103 37.0
Urinary bladder 53,006 35.4 16,968 8.7 69,974 20.2
Kidney and renal pelvis 34,459 21.3 20,772 11.2 55,231 15.9
Ureter 1,195 0.8 723 0.4 1,918 0.6
Other urinary organs 662 0.5 318 0.2 980 0.3
Eye and orbit 1,494 1.0 1,239 0.7 2,733 0.8
Brain and other nervous system 11,951 7.6 9,539 5.5 21,490 6.5
Brain 11,263 7.2 8,888 5.1 20,151 6.0
Cranial nerves other nervous system 688 0.5 651 0.4 1,339 0.4
Endocrine system 12,497 7.9 36,097 21.9 48,594 15.0
Thyroid 11,313 7.1 34,966 21.3 46,279 14.3
Other endocrine including thymus 1,184 0.8 1,131 0.7 2,315 0.7
Lymphomas 39,074 25.3 32,618 17.8 71,692 21.1
Hodgkin lymphoma 4,569 3.0 3,704 2.3 8,273 2.6
Non-Hodgkin lymphoma 34,505 22.3 28,914 15.5 63,419 18.5
Myeloma 12,199 7.8 9,630 5.0 21,829 6.3
Leukemias 25,699 16.9 18,697 10.3 44,396 13.2
Acute lymphocytic leukemia 2,732 1.8 2,114 1.4 4,846 1.6
Chronic lymphocytic leukemia 9,004 5.8 5,817 3.0 14,821 4.2
Acute myeloid leukemia 7,646 5.1 6,174 3.4 13,820 4.1
Chronic myeloid leukemia 3,118 2.1 2,425 1.4 5,543 1.7
Other leukemias 3,199 2.1 2,167 1.2 5,366 1.6
Mesothelioma 2,407 1.7 792 0.4 3,199 0.9
Kaposi Sarcoma 951 0.6 125 0.1 1,076 0.3
Miscellaneous 29,297 19.6 26,579 13.7 55,876 16.3

Abbreviations: NA = not applicable; NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.

Return to your place in the textTABLE 8. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site and sex — United States, 2012
Cancer site Male Female Total
No. Rate No. Rate No. Rate
All cancer sites combined 305,661 200.6 276,946 141.9 582,607 166.4
Oral cavity and pharynx 6,263 3.9 2,661 1.3 8,924 2.5
Lip 44 0 27 0 71 0
Tongue 1,488 0.9 736 0.4 2,224 0.6
Salivary gland 581 0.4 288 0.1 869 0.2
Floor of mouth 54 0 21 0 75 0
Gum and other mouth 746 0.5 529 0.3 1,275 0.4
Nasopharynx 454 0.3 212 0.1 666 0.2
Tonsil 714 0.4 165 0.1 879 0.2
Oropharynx 653 0.4 238 0.1 891 0.2
Hypopharynx 268 0.2 88 0 356 0.1
Other oral cavity and pharynx 1,261 0.8 357 0.2 1,618 0.4
Digestive system 83,782 53.4 63,242 32.0 147,024 41.6
Esophagus 11,697 7.3 2,952 1.5 14,649 4.1
Stomach 6,611 4.3 4,580 2.4 11,191 3.2
Small intestine 689 0.5 604 0.3 1,293 0.4
Colon and rectum 26,866 17.6 24,650 12.4 51,516 14.7
Colon excluding rectum 21,383 14.1 20,484 10.3 41,867 12.0
Rectum and rectosigmoid junction 5,483 3.5 4,166 2.1 9,649 2.7
Anus, anal canal, and anorectum 368 0.2 521 0.3 889 0.3
Liver and intrahepatic bile duct 15,563 9.4 7,409 3.8 22,972 6.3
Gallbladder 687 0.5 1,415 0.7 2,102 0.6
Other biliary 739 0.5 780 0.4 1,519 0.4
Pancreas 19,718 12.7 19,079 9.6 38,797 11.0
Retroperitoneum 110 0.1 97 0.1 207 0.1
Peritoneum, omentum, and mesentery 78 0 672 0.3 750 0.2
Other digestive organs 656 0.4 483 0.2 1,139 0.3
Respiratory system 90,091 58.4 71,760 37.0 161,851 46.2
Nose, nasal cavity, and middle ear 285 0.2 173 0.1 458 0.1
Larynx 2,925 1.8 737 0.4 3,662 1.0
Lung and bronchus 86,689 56.2 70,734 36.4 157,423 45.0
Pleura 51 0 31 0 82 0
Trachea, mediastinum, and other respiratory organs 141 0.1 85 0 226 0.1
Bones and joints 818 0.5 581 0.3 1,399 0.4
Soft tissue including heart 2,394 1.6 2,165 1.2 4,559 1.3
Skin excluding basal and squamous 8,329 5.5 4,134 2.1 12,463 3.6
Melanoma of the skin 6,013 4.0 3,238 1.7 9,251 2.7
Other nonepithelial skin 2,316 1.6 896 0.4 3,212 0.9
Male and female breast NA NA NA NA 41,555 11.8
Female breast NA NA 41,150 21.3 NA NA
Male breast 405 0.3 NA NA NA NA
Female genital system NA NA 29,405 15.2 NA NA
Cervix NA NA 4,074 2.3 NA NA
Corpus and uterus, NOS NA NA 8,911 4.5 NA NA
Corpus NA NA 3,812 1.9 NA NA
Uterus, NOS NA NA 5,099 2.6 NA NA
Ovary NA NA 14,404 7.4 NA NA
Vagina NA NA 429 0.2 NA NA
Vulva NA NA 1,034 0.5 NA NA
Other female genital organs NA NA 553 0.3 NA NA
Male genital system 27,955 20.0 NA NA NA NA
Prostate 27,244 19.6 NA NA NA NA
Testis 386 0.3 NA NA NA NA
Penis 273 0.2 NA NA NA NA
Other male genital organs 52 0 NA NA NA NA
Urinary system 20,136 13.6 9,458 4.7 29,594 8.5
Urinary bladder 10,886 7.6 4,359 2.1 15,245 4.4
Kidney and renal pelvis 8,772 5.6 4,746 2.4 13,518 3.8
Ureter 212 0.1 166 0.1 378 0.1
Other urinary organs 266 0.2 187 0.1 453 0.1
Eye and orbit 164 0.1 115 0.1 279 0.1
Brain and other nervous system 8,666 5.4 6,610 3.5 15,276 4.4
Endocrine system 1,264 0.8 1,396 0.7 2,660 0.8
Thyroid 775 0.5 915 0.5 1,690 0.5
Other endocrine including thymus 489 0.3 481 0.3 970 0.3
Lymphomas 11,902 8.0 9,616 4.9 21,518 6.2
Hodgkin lymphoma 638 0.4 492 0.3 1,130 0.3
Non-Hodgkin lymphoma 11,264 7.6 9,124 4.6 20,388 5.9
Myeloma 6,338 4.2 5,483 2.8 11,821 3.4
Leukemias 13,466 9.2 9,843 5.1 23,309 6.8
Acute lymphocytic leukemia 810 0.5 598 0.3 1,408 0.4
Chronic lymphocytic leukemia 2,837 2.0 1,761 0.9 4,598 1.3
Acute myeloid leukemia 5,401 3.6 4,083 2.2 9,484 2.8
Chronic myeloid leukemia 546 0.4 471 0.2 1,017 0.3
Other leukemias 3,872 2.7 2,930 1.5 6,802 2.0
Mesothelioma 2,112 1.5 574 0.3 2,686 0.8
Miscellaneous 21,538 14.1 18,738 9.4 40,276 11.5

Abbreviations: NA = not applicable; NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).

Return to your place in the textTABLE 9. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site and race§ —United States, 2012
Cancer site AI/AN§ API§ Black White Total
No. Rate No. Rate No. Rate No. Rate No. Rate
All cancer sites combined 8,139 269.0 45,364 285.7 165,559 446.1 1,282,703 440.4 1,529,078 440.3
Oral cavity and pharynx 227 6.8 1,267 7.7 3,574 9.1 34,263 11.5 39,879 11.2
Lip —** 42 0.1 1,718 0.6 1,842 0.5
Tongue 51 1.5 288 1.8 786 2.0 11,082 3.7 12,374 3.4
Salivary gland 18 0.5 180 1.1 393 1.0 3,597 1.3 4,254 1.3
Floor of mouth 26 0.2 206 0.5 1,666 0.5 1,936 0.5
Gum and other mouth 24 0.8 207 1.3 511 1.4 4,500 1.5 5,331 1.5
Nasopharynx 21 0.6 384 2.2 263 0.7 1,064 0.4 1,758 0.5
Tonsil 45 1.2 81 0.5 625 1.5 6,512 2.2 7,330 2.0
Oropharynx 20 0.1 241 0.6 1,449 0.5 1,733 0.5
Hypopharynx 21 0.7 54 0.3 390 1.0 1,796 0.6 2,281 0.6
Other oral cavity and pharynx 16 0.5 117 0.3 879 0.3 1,040 0.3
Digestive system 1,722 58.4 11,016 72.1 34,404 94.8 223,154 75.7 273,535 78.3
Esophagus 73 2.6 303 2.0 1,514 4.1 13,963 4.7 15,993 4.5
Stomach 167 6.1 1,571 10.5 3,532 10.2 17,056 5.8 22,623 6.6
Small intestine 25 0.8 181 1.1 1,301 3.5 6,300 2.2 7,894 2.3
Colon and rectum 835 28.5 4,772 30.8 16,402 45.5 111,041 38.0 134,784 38.9
Colon excluding rectum 547 19.7 3,073 20.3 12,256 34.6 79,012 27.1 95,962 27.8
Rectum and rectosigmoid junction 288 8.8 1,699 10.5 4,146 10.9 32,029 11.0 38,822 11.1
Anus, anal canal, and anorectum 33 0.9 81 0.5 703 1.8 5,450 1.8 6,338 1.8
Liver and Intrahepatic bile duct 280 8.5 2,008 12.7 4,097 10.0 21,223 7.0 28,012 7.7
Gallbladder 48 1.9 204 1.4 558 1.6 2,979 1.0 3,835 1.1
Other biliary 28 0.9 363 2.5 506 1.5 5,023 1.7 5,963 1.7
Pancreas 197 7.0 1,340 9.3 5,293 15.1 36,001 12.1 43,213 12.3
Retroperitoneum 43 0.3 164 0.4 1,088 0.4 1,321 0.4
Peritoneum, omentum, and mesentery 70 0.4 135 0.4 1,698 0.6 1,924 0.5
Other digestive organs 80 0.5 199 0.6 1,332 0.5 1,635 0.5
Respiratory system 1,167 42.3 5,369 36.8 24,484 68.6 193,417 65.2 225,933 64.7
Nose, nasal cavity, and middle ear 94 0.6 232 0.6 1,908 0.7 2,274 0.7
Larynx 56 1.8 159 1.0 1,706 4.4 10,123 3.3 12,152 3.4
Lung and bronchus 1,096 40.1 5,088 35.0 22,475 63.3 180,823 61.0 210,828 60.4
Pleura 91 0 105 0
Trachea, mediastinum, and other respiratory organs 26 0.2 61 0.2 472 0.2 574 0.2
Bones and joints 19 0.4 109 0.6 308 0.7 2,458 1.0 2,951 0.9
Soft tissue including heart 72 2.1 356 2.1 1,308 3.4 8,809 3.2 10,728 3.2
Skin excluding basal and squamous 167 5.6 315 2.0 664 1.8 68,552 24.2 73,181 21.5
Melanoma of the skin 141 4.7 197 1.2 332 0.9 63,875 22.6 67,753 19.9
Other nonepithelial skin 26 0.8 118 0.8 332 0.9 4,677 1.6 5,428 1.6
Male and female breast 1,145 36.1 8,416 49.3 25,927 68.5 188,474 65.5 226,272 65.6
Female breast 1,143 67.8 8,357 89.7 25,630 120.1 186,726 123.3 224,147 122.2
Male breast 59 0.8 297 2.0 1,748 1.3 2,125 1.4
Female genital system 598 33.9 3,279 34.9 10,015 46.9 75,241 49.4 90,303 48.8
Cervix 119 6.3 576 6.1 1,907 9.0 9,174 7.1 12,042 7.4
Corpus and uterus, NOS 290 15.9 1,704 17.9 5,334 24.7 41,235 26.1 49,154 25.7
Corpus 281 15.3 1,648 17.3 4,995 23.1 40,082 25.3 47,570 24.9
Uterus, NOS 56 0.6 339 1.6 1,153 0.7 1,584 0.8
Ovary 138 8.4 810 8.7 1,959 9.3 17,671 11.6 20,785 11.3
Vagina 37 0.4 199 1.0 1,031 0.7 1,296 0.7
Vulva 24 1.5 66 0.8 413 2.0 4,285 2.7 4,851 2.6
Other female genital organs 16 1.0 86 1.0 203 1.0 1,845 1.2 2,175 1.2
Male genital system 832 60.1 3,975 57.1 28,484 172.2 146,244 103.0 187,308 111.8
Prostate 750 56.4 3,755 54.5 28,003 169.4 137,488 95.6 177,489 105.3
Testis 76 3.2 164 1.8 305 1.5 7,410 6.3 8,189 5.5
Penis 37 0.6 142 1.0 1,070 0.8 1,283 0.8
Other male genital organs 19 0.3 34 0.2 276 0.2 347 0.2
Urinary system 710 23.9 2,443 16.4 10,399 28.8 112,781 38.4 128,103 37.0
Urinary bladder 222 8.6 1,208 8.6 3,778 11.3 63,564 21.5 69,974 20.2
Kidney and renal pelvis 480 15.0 1,165 7.3 6,420 16.9 46,625 16.0 55,231 15.9
Ureter 53 0.4 80 0.2 1,769 0.6 1,918 0.6
Other urinary organs 17 0.1 121 0.3 823 0.3 980 0.3
Eye and orbit 36 0.2 93 0.2 2,513 0.9 2,733 0.8
Brain and other nervous system 114 3.2 622 3.6 1,615 4.1 18,858 6.9 21,490 6.5
Brain 107 3.1 576 3.4 1,465 3.7 17,765 6.5 20,151 6.0
Cranial nerves other nervous system 46 0.3 150 0.4 1,093 0.4 1,339 0.4
Endocrine system 285 7.4 2,822 15.6 3,893 9.9 40,662 15.6 48,594 15.0
Thyroid 275 7.2 2,677 14.8 3,529 8.9 38,888 14.9 46,279 14.3
Other endocrine including thymus 145 0.8 364 0.9 1,774 0.7 2,315 0.7
Lymphomas 340 11.6 2,154 13.7 6,185 16.1 61,671 21.7 71,692 21.1
Hodgkin lymphoma 32 0.9 212 1.1 1,096 2.6 6,787 2.7 8,273 2.6
Non-Hodgkin lymphoma 308 10.8 1,942 12.5 5,089 13.5 54,884 19.0 63,419 18.5
Myeloma 116 4.1 491 3.2 4,392 12.4 16,480 5.6 21,829 6.3
Leukemias 252 7.9 1,200 7.5 3,838 10.5 37,968 13.5 44,396 13.2
Acute lymphocytic leukemia 51 1.2 242 1.4 440 1.0 4,011 1.7 4,846 1.6
Chronic lymphocytic leukemia 51 1.9 172 1.1 1,066 3.1 12,921 4.3 14,821 4.2
Acute myeloid leukemia 86 2.8 495 3.2 1,294 3.6 11,808 4.2 13,820 4.1
Chronic myeloid leukemia 36 1.2 177 1.1 564 1.5 4,631 1.7 5,543 1.7
Other leukemias 28 0.8 114 0.7 474 1.3 4,597 1.6 5,366 1.6
Mesothelioma 35 0.3 162 0.5 2,963 1.0 3,199 0.9
Kaposi Sarcoma 27 0.1 320 0.8 648 0.3 1,076 0.3
Miscellaneous 342 12.9 1,432 10.0 5,494 16.0 47,547 16.2 55,876 16.3

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander; NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Rates are not presented for persons of unknown or other race, therefore categories do not sum to total. Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
**Counts and rates are suppressed if <16 cases were reported.

Return to your place in the textTABLE 10. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site and race — United States, 2012§
Cancer site AI/ANI APII Black White Total
No. Rate No. Rate No. Rate No. Rate No. Rate
All cancer sites combined 3,018 112.5 15,339 104.2 67,374 194.4 496,876 166.4 582,607 166.4
Oral cavity and pharynx 48 1.6 320 2.0 1,074 2.9 7,482 2.5 8,924 2.5
Lip 68 0 71 0
Tongue 58 0.4 200 0.5 1,956 0.6 2,224 0.6
Salivary gland 19 0.1 67 0.2 781 0.3 869 0.2
Floor of mouth 71 0 75 0
Gum and other mouth 41 0.3 118 0.3 1,108 0.4 1,275 0.4
Nasopharynx 141 0.8 100 0.3 419 0.1 666 0.2
Tonsil 108 0.3 753 0.2 879 0.2
Oropharynx 17 0.1 146 0.4 723 0.2 891 0.2
Hypopharynx 50 0.1 297 0.1 356 0.1
Other oral cavity and pharynx 21 0.1 281 0.8 1,306 0.4 1,618 0.4
Digestive system 908 33.1 5,511 37.5 18,930 53.9 121,675 40.5 147,024 41.6
Esophagus 67 2.5 241 1.6 1,387 3.7 12,954 4.3 14,649 4.1
Stomach 100 3.9 832 5.7 2,001 5.9 8,258 2.8 11,191 3.2
Small intestine 32 0.2 199 0.5 1,060 0.4 1,293 0.4
Colon and rectum 301 11.2 1,578 10.8 6,861 19.9 42,776 14.3 51,516 14.7
Colon excluding rectum 246 9.2 1,270 8.8 5,727 16.8 34,624 11.6 41,867 12.0
Rectum and rectosigmoid junction 55 2.0 308 2.0 1,134 3.2 8,152 2.7 9,649 2.7
Anus, anal canal, and anorectum 99 0.3 778 0.3 889 0.3
Liver and intrahepatic bile duct 207 7.0 1,499 9.9 3,190 8.3 18,076 5.9 22,972 6.3
Gallbladder 24 1.1 86 0.6 285 0.8 1,707 0.6 2,102 0.6
Other biliary 61 0.4 121 0.4 1,327 0.4 1,519 0.4
Pancreas 180 6.5 1,113 7.9 4,595 13.4 32,909 10.9 38,797 11.0
Retroperitoneum 16 0 184 0.1 207 0.1
Peritoneum, omentum, and mesentery 18 0.1 50 0.1 679 0.2 750 0.2
Other digestive organs 37 0.3 126 0.4 967 0.3 1,139 0.3
Respiratory system 818 31.1 3,528 24.6 17,484 50.3 140,021 46.9 161,851 46.2
Nose, nasal cavity, and middle ear 19 0.1 40 0.1 397 0.1 458 0.1
Larynx 18 0.6 56 0.4 628 1.7 2,960 1.0 3,662 1.0
Lung and bronchus 796 30.4 3,441 24.0 16,780 48.4 136,406 45.7 157,423 45.0
Pleura 75 0 82 0
Trachea, mediastinum, and other respiratory organs 31 0.1 183 0.1 226 0.1
Bones and joints 42 0.3 165 0.4 1,186 0.4 1,399 0.4
Soft tissue including heart 35 1.1 147 0.9 567 1.5 3,810 1.3 4,559 1.3
Skin excluding basal and squamous 32 1.3 90 0.6 273 0.8 12,068 4.1 12,463 3.6
Melanoma of the skin 19 0.8 58 0.4 138 0.4 9,036 3.1 9,251 2.7
Other nonepithelial skin 32 0.2 135 0.4 3,032 1.0 3,212 0.9
Male and female breast 173 5.9 1,036 6.3 6,246 17.2 34,100 11.4 41,555 11.8
Female breast 172 10.8 1,032 11.3 6,186 29.4 33,760 20.7 41,150 21.3
Male breast 60 0.4 340 0.3 405 0.3
Female genital system 171 11.1 858 9.6 3,984 19.4 24,392 15.0 29,405 15.2
Cervix 41 2.3 154 1.7 780 3.7 3,099 2.1 4,074 2.3
Corpus and uterus, NOS 47 3.1 280 3.2 1,666 8.2 6,918 4.1 8,911 4.5
Corpus 21 1.2 131 1.5 646 3.2 3,014 1.8 3,812 1.9
Uterus, NOS 26 1.8 149 1.7 1,020 5.0 3,904 2.3 5,099 2.6
Ovary 74 5.0 385 4.3 1,359 6.6 12,586 7.7 14,404 7.4
Vagina 56 0.3 360 0.2 429 0.2
Vulva 64 0.3 952 0.6 1,034 0.5
Other female genital organs 16 0.2 59 0.3 477 0.3 553 0.3
Male genital system 134 14.4 441 8.6 4,655 42.1 22,725 18.6 27,955 20.0
Prostate 127 14.0 429 8.4 4,595 41.8 22,093 18.1 27,244 19.6
Testis 26 0.1 347 0.3 386 0.3
Penis 27 0.2 241 0.2 273 0.2
Other male genital organs 44 0 52 0
Urinary system 148 5.5 507 3.7 2,411 7.2 26,528 8.8 29,594 8.5
Urinary bladder 33 1.3 232 1.8 1,090 3.5 13,890 4.6 15,245 4.4
Kidney and renal pelvis 107 3.9 256 1.7 1,267 3.6 11,888 4.0 13,518 3.8
Ureter 351 0.1 378 0.1
Other urinary organs 41 0.1 399 0.1 453 0.1
Eye and orbit 260 0.1 279 0.1
Brain and other nervous system 63 2.0 336 2.1 1,009 2.7 13,868 4.8 15,276 4.4
Endocrine system 134 0.9 311 0.9 2,208 0.8 2,660 0.8
Thyroid 90 0.6 165 0.5 1,430 0.5 1,690 0.5
Other endocrine including thymus 44 0.3 146 0.4 778 0.3 970 0.3
Lymphomas 75 3.2 587 4.1 1,595 4.6 19,261 6.5 21,518 6.2
Hodgkin lymphoma 20 0.1 133 0.3 974 0.3 1,130 0.3
Non-Hodgkin lymphoma 72 3.2 567 4.0 1,462 4.3 18,287 6.2 20,388 5.9
Myeloma 48 2.0 241 1.7 2,085 6.3 9,447 3.2 11,821 3.4
Leukemias 96 3.4 599 4.1 1,965 5.8 20,649 7.1 23,309 6.8
Acute lymphocytic leukemia 53 0.3 121 0.3 1,222 0.5 1,408 0.4
Chronic lymphocytic leukemia 38 0.3 365 1.2 4,183 1.4 4,598 1.3
Acute myeloid leukemia 44 1.5 323 2.2 768 2.2 8,349 2.9 9,484 2.8
Chronic myeloid leukemia 21 0.1 108 0.3 885 0.3 1,017 0.3
Other leukemias 25 1.0 164 1.2 603 1.8 6,010 2.0 6,802 2.0
Mesothelioma 28 0.2 125 0.4 2,519 0.9 2,686 0.8
Miscellaneous 236 8.9 930 6.5 4,471 12.9 34,639 11.5 40,276 11.5

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander; NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
§Data are from the National Vital Statistics System (NVSS).
Counts and rates are suppressed if <16 deaths were reported.

Return to your place in the textTABLE 11. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site and ethnicity§ — United States, 2012
Cancer site Hispanic Non-Hispanic Total
No. Rate No. Rate No. Rate
All cancer sites combined 111,815 340.5 1,417,061 451.4 1,529,078 440.3
Oral cavity and pharynx 2,318 6.9 37,561 11.7 39,879 11.2
Lip 87 0.3 1,755 0.6 1,842 0.5
Tongue 629 1.9 11,745 3.6 12,374 3.4
Salivary gland 324 0.9 3,930 1.3 4,254 1.3
Floor of mouth 90 0.3 1,846 0.6 1,936 0.5
Gum and other mouth 366 1.2 4,965 1.6 5,331 1.5
Nasopharynx 148 0.4 1,610 0.5 1,758 0.5
Tonsil 364 1.0 6,966 2.1 7,330 2.0
Oropharynx 97 0.3 1,636 0.5 1,733 0.5
Hypopharynx 139 0.4 2,142 0.6 2,281 0.6
Other oral cavity and pharynx 74 0.2 966 0.3 1,040 0.3
Digestive system 24,117 78.3 249,370 78.5 273,535 78.3
Esophagus 847 2.8 15,143 4.7 15,993 4.5
Stomach 2,926 9.5 19,694 6.2 22,623 6.6
Small intestine 561 1.7 7,333 2.3 7,894 2.3
Colon and rectum 10,585 34.0 124,186 39.5 134,784 38.9
Colon excluding rectum 7,158 23.8 88,791 28.3 95,962 27.8
Rectum and rectosigmoid junction 3,427 10.2 35,395 11.2 38,822 11.1
Anus, anal canal, and anorectum 449 1.4 5,888 1.9 6,338 1.8
Liver and Intrahepatic bile duct 4,066 12.7 23,937 7.2 28,012 7.7
Gallbladder 539 1.9 3,295 1.0 3,835 1.1
Other biliary 650 2.2 5,313 1.7 5,963 1.7
Pancreas 3,079 10.7 40,116 12.5 43,213 12.3
Retroperitoneum 128 0.3 1,193 0.4 1,321 0.4
Peritoneum, omentum, and mesentery 134 0.4 1,790 0.6 1,924 0.5
Other digestive organs 153 0.5 1,482 0.5 1,635 0.5
Respiratory system 9,655 34.4 216,231 67.5 225,933 64.7
Nose, nasal cavity, and middle ear 191 0.6 2,083 0.7 2,274 0.7
Larynx 736 2.4 11,413 3.5 12,152 3.4
Lung and bronchus 8,648 31.2 202,136 63.2 210,828 60.4
Pleura —** 101 0 0
Trachea, mediastinum, and other respiratory organs 76 0.1 498 0.2 574 0.2
Bones and joints 415 0.9 2,536 0.9 2,951 0.9
Soft tissue including heart 1,092 2.8 9,636 3.3 10,728 3.2
Skin excluding basal and squamous 1,726 5.1 71,452 23.6 73,181 21.5
Melanoma of the skin 1,423 4.2 66,328 21.9 67,753 19.9
Other nonepithelial skin 303 0.9 5,124 1.7 5,428 1.6
Male and female breast 17,129 49.0 209,135 67.6 226,272 65.6
Female breast 17,014 91.3 207,125 125.9 224,147 122.2
Male breast 115 0.8 2,010 1.4 2,125 1.4
Female genital system 8,557 44.5 81,736 49.1 90,303 48.8
Cervix 1,998 9.5 10,044 7.1 12,042 7.4
Corpus and uterus, NOS 4,135 21.8 45,015 26.0 49,154 25.7
Corpus 3,976 20.9 43,593 25.2 47,570 24.9
Uterus, NOS 159 0.9 1,422 0.8 1,584 0.8
Ovary 1,885 10.0 18,894 11.4 20,785 11.3
Vagina 108 0.6 1,188 0.7 1,296 0.7
Vulva 268 1.7 4,583 2.7 4,851 2.6
Other female genital organs 163 0.9 2,012 1.2 2,175 1.2
Male genital system 13,653 95.7 173,628 113.7 187,308 111.8
Prostate 12,121 89.8 165,342 107.0 177,489 105.3
Testis 1,311 4.4 6,877 5.7 8,189 5.5
Penis 204 1.4 1,079 0.8 1,283 0.8
Other male genital organs 17 0.1 330 0.2 347 0.2
Urinary system 8,518 27.4 119,571 37.9 128,103 37.0
Urinary bladder 3,041 11.1 66,925 21.1 69,974 20.2
Kidney and renal pelvis 5,350 15.9 49,875 15.9 55,231 15.9
Ureter 80 0.3 1,838 0.6 1,918 0.6
Other urinary organs 47 0.2 933 0.3 980 0.3
Eye and orbit 206 0.5 2,527 0.9 2,733 0.8
Brain and other nervous system 1,990 4.9 19,497 6.7 21,490 6.5
Brain 1,846 4.6 18,302 6.3 20,151 6.0
Cranial nerves other nervous system 144 0.3 1,195 0.5 1,339 0.4
Endocrine system 5,806 13.7 42,783 15.4 48,594 15.0
Thyroid 5,555 13.1 40,722 14.6 46,279 14.3
Other endocrine including thymus 251 0.6 2,061 0.7 2,315 0.7
Lymphomas 6,462 18.9 65,222 21.5 71,692 21.1
Hodgkin lymphoma 1,029 2.3 7,244 2.7 8,273 2.6
Non-Hodgkin lymphoma 5,433 16.6 57,978 18.7 63,419 18.5
Myeloma 1,869 6.2 19,955 6.3 21,829 6.3
Leukemias 3,988 10.3 40,403 13.4 44,396 13.2
Acute lymphocytic leukemia 1,264 2.2 3,582 1.5 4,846 1.6
Chronic lymphocytic leukemia 542 1.9 14,278 4.5 14,821 4.2
Acute myeloid leukemia 1,272 3.6 12,546 4.1 13,820 4.1
Chronic myeloid leukemia 490 1.4 5,051 1.7 5,543 1.7
Other leukemias 420 1.2 4,946 1.6 5,366 1.6
Mesothelioma 200 0.7 2,997 1.0 3,199 0.9
Kaposi Sarcoma 198 0.5 878 0.3 1,076 0.3
Miscellaneous 3,916 13.6 51,943 16.5 55,876 16.3

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Rates and counts are not presented for persons of unknown ethnicity, therefore categories do not sum to total. Data for specified ethnic populations should be interpreted with caution. For more information, see USCS technical notes http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
**Counts and rates are suppressed if <16 cases were reported. Some counts and rates are suppressed as complementary cell suppression.

Return to your place in the textTABLE 12. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site and ethnicity — United States, 2012§
Cancer site Hispanic§ Non-Hispanic Total
No. Rate No. Rate No. Rate
All cancer sites combined 34,146 117.8 547,027 170.4 582,607 166.4
Oral cavity and pharynx 476 1.6 8,421 2.6 8,924 2.5
Lip 65 0 71 0
Tongue 118 0.4 2,099 0.6 2,224 0.6
Salivary gland 48 0.2 819 0.3 869 0.2
Floor of mouth 68 0 75 0
Gum and other mouth 66 0.2 1,206 0.4 1,275 0.4
Nasopharynx 37 0.1 627 0.2 666 0.2
Tonsil 39 0.1 835 0.3 879 0.2
Oropharynx 43 0.1 848 0.3 891 0.2
Hypopharynx 25 0.1 329 0.1 356 0.1
Other oral cavity and pharynx 87 0.3 1,525 0.5 1,618 0.4
Digestive system 11,382 39.3 135,287 41.8 147,024 41.6
Esophagus 621 2.1 13,995 4.3 14,649 4.1
Stomach 1,590 5.2 9,570 3.0 11,191 3.2
Small intestine 68 0.2 1,221 0.4 1,293 0.4
Colon and rectum 3,349 11.8 48,034 15.0 51,516 14.7
Colon excluding rectum 2,737 9.7 39,017 12.2 41,867 12.0
Rectum and rectosigmoid junction 612 2.0 9,017 2.8 9,649 2.7
Anus, anal canal, and anorectum 40 0.1 845 0.3 889 0.3
Liver and intrahepatic bile duct 2,780 9.3 20,135 6.1 22,972 6.3
Gallbladder 262 1.0 1,833 0.6 2,102 0.6
Other biliary 136 0.5 1,383 0.4 1,519 0.4
Pancreas 2,407 8.6 36,307 11.2 38,797 11.0
Retroperitoneum 16 0 190 0.1 207 0.1
Peritoneum, omentum, and mesentery 46 0.1 703 0.2 750 0.2
Other digestive organs 67 0.2 1,071 0.3 1,139 0.3
Respiratory system 5,503 20.4 155,925 48.4 161,851 46.2
Nose, nasal cavity, and middle ear 37 0.1 420 0.1 458 0.1
Larynx 214 0.8 3,433 1.0 3,662 1.0
Lung and bronchus 5,225 19.4 151,793 47.1 157,423 45.0
Pleura 77 0 82 0
Trachea, mediastinum, and other respiratory organs 22 0.1 202 0.1 226 0.1
Bones and joints 136 0.3 1,262 0.4 1,399 0.4
Soft tissue including heart 390 1.1 4,155 1.4 4,559 1.3
Skin excluding basal and squamous 350 1.2 12,085 3.8 12,463 3.6
Melanoma of the skin 224 0.7 9,010 2.9 9,251 2.7
Other nonepithelial skin 126 0.5 3,075 0.9 3,212 0.9
Male and female breast 2,627 8.1 38,826 12.1 41,555 11.8
Female breast 2,613 14.7 38,436 21.9 41,150 21.3
Male breast 390 0.3 405 0.3
Female genital system 2,212 12.8 27,113 15.4 29,405 15.2
Cervix 520 2.7 3,536 2.2 4,074 2.3
Corpus and uterus, NOS 619 3.7 8,269 4.6 8,911 4.5
Corpus 245 1.5 3,555 2.0 3,812 1.9
Uterus, NOS 374 2.2 4,714 2.6 5,099 2.6
Ovary 963 5.8 13,407 7.5 14,404 7.4
Vagina 32 0.2 396 0.2 429 0.2
Vulva 45 0.3 986 0.5 1,034 0.5
Other female genital organs 33 0.2 519 0.3 553 0.3
Male genital system 1,706 17.1 26,189 20.2 27,955 20.0
Prostate 1,592 16.5 25,595 19.8 27,244 19.6
Testis 75 0.2 309 0.2 386 0.3
Penis 36 0.3 237 0.2 273 0.2
Other male genital organs 48 0 52 0
Urinary system 1,660 6.0 27,875 8.6 29,594 8.5
Urinary bladder 584 2.3 14,630 4.5 15,245 4.4
Kidney and renal pelvis 1,042 3.6 12,451 3.8 13,518 3.8
Ureter 362 0.1 378 0.1
Other urinary organs 19 0.1 432 0.1 453 0.1
Eye and orbit 18 0.1 260 0.1 279 0.1
Brain and other nervous system 1,049 3.0 14,194 4.6 15,276 4.4
Endocrine system 248 0.8 2,409 0.8 2,660 0.8
Thyroid 168 0.6 1,521 0.5 1,690 0.5
Other endocrine including thymus 80 0.2 888 0.3 970 0.3
Lymphomas 1,551 5.4 19,914 6.3 21,518 6.2
Hodgkin lymphoma 123 0.4 1,005 0.3 1,130 0.3
Non-Hodgkin lymphoma 1,428 5.0 18,909 6.0 20,388 5.9
Myeloma 782 2.9 11,019 3.4 11,821 3.4
Leukemias 1,603 5.0 21,661 6.9 23,309 6.8
Acute lymphocytic leukemia 325 0.7 1,080 0.4 1,408 0.4
Chronic lymphocytic leukemia 125 0.5 4,463 1.4 4,598 1.3
Acute myeloid leukemia 582 1.9 8,885 2.9 9,484 2.8
Chronic myeloid leukemia 76 0.3 936 0.3 1,017 0.3
Other leukemias 495 1.7 6,297 2.0 6,802 2.0
Mesothelioma 132 0.5 2,545 0.8 2,686 0.8
Miscellaneous 2,313 8.2 37,842 11.7 40,276 11.5

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).
§Data for specified ethnic populations should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
Counts and rates are suppressed if <16 deaths were reported.

Return to your place in the textFIGURE 1. Age-adjusted rate* of invasive cancer cases for most common sites, by sex and race/ethnicity§ — United States, 2012
The figure presents 10 bar charts showing the age-adjusted rate per 100,000 population for 2012 for three types of invasive cancer — breast, lung and bronchus, and rectum — by sex and race/ethnicity. Data are drawn from CDC’s National Program of Cancer Registries and the National Cancer Institute’s Surveillance, Epidemiology, and End Results program.

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander.

Sources: CDC’s National Program of Cancer Registries and National Cancer Institute’s Surveillance, Epidemiology, and End Results program.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Race categories are not mutually exclusive from Hispanic origin. Rates are not presented for persons of unknown or other race. Data for specified racial or ethnic populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria. Caution should be used when comparing incidence and death rates because of the difference in population coverage.

Return to your place in the textFIGURE 2. Age-adjusted rate* of invasive cancer cases, by primary cancer site and state — United States, 2012§
This figure presents six maps of the United States showing the age-adjusted rate per 100,000 persons of invasive cancer cases for 2012 by primary cancer site for all cancer sites combined, female breast, lung, prostate, cervix uteri, and colon and rectum. The number of cases varies by state.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Return to your place in the textFIGURE 3. Age-adjusted rate* of cancer deaths, by primary cancer site and state — United States, 2012
This figure presents six maps of the United States showing the age-adjusted rate per 100,000 persons of cancer deaths for 2012 by primary cancer site for all cancer sites combined, female breast, lung, prostate, cervix uteri, and colon and rectum. The number of cases varies by state.

* Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS Technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Data are from the National Vital Statistics System (NVSS). Data for death rates cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Return to your place in the textTABLE 13. Reported number of invasive* cancer cases by primary cancer site and year — United States, 1999–2012
Cancer site 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
All cancer sites combined 1,227,562 1,249,559 1,273,017 1,285,618 1,279,510 1,296,877 1,318,814 1,349,590 1,387,116 1,402,567 1,414,111 1,403,565 1,424,734 1,399,978
Oral cavity and pharynx 27,491 27,954 28,236 28,904 29,506 29,980 30,315 31,314 32,798 34,214 34,619 35,395 36,790 36,990
Lip 2,444 2,393 2,309 2,333 2,041 1,961 1,859 1,880 1,883 1,867 1,832 1,952 1,886 1,725
Tongue 6,640 6,859 7,017 7,478 7,737 8,091 8,298 8,725 9,399 10,100 10,224 10,282 11,118 11,476
Salivary gland 2,982 3,147 3,180 3,220 3,305 3,357 3,470 3,599 3,628 3,754 3,774 3,762 3,792 3,986
Floor of mouth 2,074 2,053 2,075 2,018 1,940 1,916 1,827 1,944 1,923 1,934 1,920 1,924 1,838 1,787
Gum and other mouth 4,357 4,197 4,312 4,236 4,387 4,348 4,338 4,372 4,564 4,759 4,663 4,846 4,927 4,915
Nasopharynx 1,471 1,527 1,416 1,535 1,622 1,559 1,618 1,565 1,722 1,713 1,601 1,660 1,635 1,640
Tonsil 3,409 3,584 3,780 4,032 4,316 4,570 4,756 5,068 5,307 5,730 6,263 6,348 6,754 6,786
Oropharynx 995 1,060 1,106 1,110 1,277 1,295 1,298 1,404 1,416 1,479 1,460 1,666 1,704 1,598
Hypopharynx 2,187 2,153 2,085 2,066 2,163 2,131 2,120 2,034 2,131 2,082 2,127 2,074 2,124 2,106
Other oral cavity and pharynx 932 981 956 876 718 752 731 723 825 796 755 881 1,012 971
Digestive system 232,437 235,790 238,113 239,050 242,294 243,671 244,545 246,111 249,358 252,542 252,284 250,837 254,183 254,508
Esophagus 12,691 12,886 13,082 13,105 13,606 14,152 14,058 14,522 14,535 15,092 15,220 14,598 14,998 14,884
Stomach 19,350 19,227 19,184 19,418 19,689 19,653 19,392 19,400 19,827 19,674 20,036 20,925 21,054 21,168
Small intestine 4,312 4,314 4,614 4,882 5,038 5,379 5,593 5,974 6,179 6,502 6,706 7,124 7,188 7,336
Colon and rectum 142,816 144,059 143,905 142,685 142,037 140,094 138,690 136,944 136,405 135,443 131,492 127,515 127,219 124,944
Colon excluding rectum 104,182 105,255 105,235 104,439 103,760 102,098 100,503 99,464 98,772 98,055 94,444 91,344 91,134 88,810
Rectum and rectosigmoid junction 38,634 38,804 38,670 38,246 38,277 37,996 38,187 37,480 37,633 37,388 37,048 36,171 36,085 36,134
Anus, anal canal, and anorectum 3,467 3,541 3,626 3,801 4,198 4,314 4,506 4,503 4,967 5,230 5,614 5,442 5,694 5,876
Liver and Intrahepatic bile duct 12,470 13,415 13,502 14,451 15,221 16,460 17,381 18,426 20,097 21,264 23,130 23,862 25,028 26,279
Gallbladder 3,102 2,992 3,149 2,980 3,122 3,140 3,231 3,279 3,314 3,330 3,550 3,538 3,607 3,614
Other biliary 3,356 3,544 4,221 4,401 4,565 4,624 4,677 4,862 4,874 5,141 5,349 5,437 5,635 5,603
Pancreas 28,024 28,801 29,421 29,804 31,085 31,922 32,985 34,137 34,961 36,519 36,950 38,112 39,242 40,229
Retroperitoneum 990 963 1,033 1,062 1,038 1,057 1,125 1,094 1,114 1,136 1,135 1,151 1,227 1,257
Peritoneum, omentum, and mesentery 1,101 1,188 1,391 1,472 1,646 1,818 1,813 1,751 1,895 1,981 1,838 1,808 1,835 1,791
Other digestive organs 758 860 985 989 1,049 1,058 1,094 1,219 1,190 1,230 1,264 1,325 1,456 1,527
Respiratory system 193,612 194,368 196,473 198,631 201,452 202,402 206,455 207,257 208,946 211,173 211,521 208,570 207,967 207,627
Nose, nasal cavity, and middle ear 1,805 1,799 1,765 1,870 1,815 1,928 1,966 1,953 2,116 2,080 2,104 2,005 2,045 2,126
Larynx 11,696 11,513 11,409 11,081 11,202 11,427 11,373 11,457 11,507 11,489 11,499 11,627 11,400 11,106
Lung and bronchus 179,444 180,405 182,729 185,079 187,813 188,372 192,465 193,219 194,673 196,903 197,245 194,261 193,906 193,768
Pleura 104 101 77 97 92 98 93 83 102 99 104 103 92 100
Trachea, mediastinum, and other respiratory organs 563 550 493 504 530 577 558 545 548 602 569 574 524 527
Bones and joints 2,472 2,462 2,627 2,645 2,577 2,640 2,752 2,692 2,755 2,687 2,808 2,708 2,766 2,769
Soft tissue including heart 7,333 7,687 7,846 8,035 8,383 8,792 9,025 8,897 9,449 9,589 9,707 9,978 9,810 10,000
Skin excluding basal and squamous 42,231 45,624 49,078 50,756 51,026 54,246 58,466 58,591 60,959 63,467 65,477 65,306 67,704 68,633
Melanoma of the skin 38,867 41,925 45,141 46,757 46,935 50,040 54,096 54,225 56,303 58,484 60,335 60,397 62,674 63,502
Other nonepithelial skin 3,364 3,699 3,937 3,999 4,091 4,206 4,370 4,366 4,656 4,983 5,142 4,909 5,030 5,131
Male and female breast 187,922 187,408 189,541 188,438 181,949 182,828 185,308 189,451 194,935 200,299 205,221 201,894 208,322 210,356
Female breast 186,459 185,946 188,139 186,934 180,386 181,216 183,738 187,819 193,211 198,411 203,405 199,991 206,446 208,404
Male breast 1,463 1,462 1,402 1,504 1,563 1,612 1,570 1,632 1,724 1,888 1,816 1,903 1,876 1,952
Female genital system 71,591 72,193 72,986 72,698 71,893 72,881 74,556 75,675 77,446 79,354 81,185 81,437 83,020 84,199
Cervix 12,991 12,984 12,399 12,079 11,726 11,491 11,719 11,653 11,705 11,623 11,807 11,395 11,339 11,145
Corpus and uterus, NOS 33,458 33,501 34,731 34,927 34,388 35,868 36,928 37,859 39,260 40,755 42,496 43,347 44,709 45,902
Corpus 32,350 32,366 33,573 33,763 33,224 34,727 35,751 36,721 38,124 39,440 41,081 41,970 43,247 44,449
Uterus, NOS 1,108 1,135 1,158 1,164 1,164 1,141 1,177 1,138 1,136 1,315 1,415 1,377 1,462 1,453
Ovary 19,875 20,339 20,361 20,075 20,187 19,805 20,113 20,175 20,131 20,409 20,000 19,569 19,524 19,382
Vagina 1,020 1,088 1,075 1,100 1,052 1,103 1,010 1,083 1,097 1,146 1,154 1,163 1,178 1,199
Vulva 3,401 3,348 3,494 3,515 3,551 3,579 3,700 3,788 3,986 4,017 4,201 4,223 4,355 4,502
Other female genital organs 846 933 926 1,002 989 1,035 1,086 1,117 1,267 1,404 1,527 1,740 1,915 2,069
Male genital system 194,920 200,489 206,681 208,978 196,114 195,842 196,522 214,202 226,520 215,968 211,749 203,731 207,234 173,864
Prostate 186,717 192,151 198,257 200,678 187,529 187,229 187,731 205,526 217,631 206,730 202,691 194,600 198,110 164,613
Testis 6,937 7,052 7,160 7,017 7,251 7,355 7,501 7,346 7,509 7,690 7,650 7,673 7,579 7,724
Penis 1,004 1,008 991 1,025 1,053 988 997 1,025 1,099 1,211 1,106 1,143 1,206 1,194
Other male genital organs 262 278 273 258 281 270 293 305 281 337 302 315 339 333
Urinary system 89,166 91,902 94,178 97,018 100,211 103,654 106,689 108,167 111,587 114,459 115,944 115,668 117,650 119,465
Urinary bladder 55,822 56,845 57,153 58,168 59,242 60,732 61,706 60,721 62,484 63,354 64,138 64,051 64,872 65,494
Kidney and renal pelvis 31,073 32,824 34,756 36,629 38,706 40,615 42,661 44,965 46,608 48,383 49,203 49,018 50,068 51,269
Ureter 1,553 1,536 1,560 1,565 1,573 1,608 1,600 1,721 1,668 1,701 1,723 1,720 1,764 1,783
Other urinary organs 718 697 709 656 690 699 722 760 827 1,021 880 879 946 919
Eye and orbit 2,185 2,266 2,283 2,258 2,441 2,459 2,440 2,484 2,538 2,514 2,537 2,438 2,474 2,589
Brain and other nervous system 17,611 17,830 17,766 18,267 18,353 18,879 18,993 19,201 19,512 19,858 20,019 19,809 19,893 19,929
Brain 16,446 16,581 16,541 17,069 17,000 17,542 17,661 17,975 18,204 18,543 18,709 18,587 18,703 18,727
Cranial nerves other nervous system 1,165 1,249 1,225 1,198 1,353 1,337 1,332 1,226 1,308 1,315 1,310 1,222 1,190 1,202
Endocrine system 19,093 21,074 22,594 24,401 25,856 28,353 31,030 33,174 36,000 39,386 41,693 42,584 43,924 45,696
Thyroid 17,385 19,322 20,731 22,557 23,905 26,263 28,946 31,071 33,816 37,089 39,506 40,322 41,814 43,523
Other endocrine including thymus 1,708 1,752 1,863 1,844 1,951 2,090 2,084 2,103 2,184 2,297 2,187 2,262 2,110 2,173
Lymphomas 56,381 57,054 58,147 59,578 60,948 62,813 63,613 63,762 65,116 66,350 67,262 67,800 67,173 67,005
Hodgkin lymphoma 7,272 7,461 7,346 7,678 7,617 7,726 7,981 7,905 7,972 8,273 8,012 8,069 7,884 7,704
Non-Hodgkin lymphoma 49,109 49,593 50,801 51,900 53,331 55,087 55,632 55,857 57,144 58,077 59,250 59,731 59,289 59,301
Myeloma 14,184 14,849 15,308 15,608 15,901 16,548 16,879 16,946 17,236 18,122 18,828 19,416 19,942 20,284
Leukemias 32,688 34,533 35,367 34,808 35,970 36,580 36,752 37,614 37,875 38,508 39,192 41,214 41,530 41,569
Acute lymphocytic leukemia 3,670 3,823 3,939 3,916 3,970 4,131 4,066 4,269 4,380 4,536 4,491 4,600 4,701 4,536
Chronic lymphocytic leukemia 10,499 11,455 12,049 12,149 12,669 13,133 13,511 13,683 13,352 13,548 13,605 13,759 13,897 13,938
Acute myeloid leukemia 9,535 10,089 10,192 9,895 10,143 10,132 10,015 10,292 10,407 10,824 10,938 12,208 12,448 12,883
Chronic myeloid leukemia 4,122 4,305 4,343 4,104 4,302 4,437 4,370 4,612 4,643 4,758 5,045 5,278 5,305 5,223
Other leukemias 4,862 4,861 4,844 4,744 4,886 4,747 4,790 4,758 5,093 4,842 5,113 5,369 5,179 4,989
Mesothelioma 2,825 2,889 2,891 2,935 2,925 2,964 3,074 2,978 2,974 3,012 3,048 3,070 3,079 3,002
Kaposi Sarcoma 1,406 1,399 1,391 1,306 1,349 1,315 1,355 1,226 1,263 1,191 1,172 1,112 1,113 1,036
Miscellaneous 32,014 31,788 31,511 31,304 30,362 30,030 30,045 29,848 29,849 29,874 29,845 30,598 30,160 30,457

Abbreviation: NOS = not otherwise specified.
*Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing number of cases and deaths because of potential differences in population coverage.

Return to your place in the textTABLE 14. Reported number of cancer deaths, by primary cancer site and year — United States, 1999–2012*
Cancer site 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
All cancer sites combined 549,829 553,080 553,760 557,264 556,890 553,880 559,303 559,880 562,867 565,460 567,614 574,738 576,685 582,607
Oral cavity and pharynx 7,486 7,492 7,701 7,737 7,777 7,826 7,773 7,720 8,067 8,019 7,922 8,474 8,657 8,924
Lip 52 67 77 74 72 74 60 51 66 68 57 69 83 71
Tongue 1,738 1,767 1,818 1,887 1,875 1,881 1,948 1,906 2,034 1,983 1,971 2,125 2,089 2,224
Salivary gland 656 663 685 722 696 697 701 699 742 718 795 827 820 869
Floor of mouth 180 153 135 149 147 122 135 114 102 99 109 93 84 75
Gum and other mouth 1,215 1,213 1,179 1,152 1,176 1,168 1,118 1,108 1,109 1,160 1,091 1,212 1,245 1,275
Nasopharynx 638 650 621 628 598 637 615 633 677 645 662 701 630 666
Tonsil 543 518 612 638 608 592 647 654 688 724 736 795 842 879
Oropharynx 600 547 592 606 626 658 655 650 721 734 720 806 861 891
Hypopharynx 385 359 348 323 318 368 281 301 324 294 279 324 322 356
Other oral cavity and pharynx 1,479 1,555 1,634 1,558 1,661 1,629 1,613 1,604 1,604 1,594 1,502 1,522 1,681 1,618
Digestive system 130,070 131,455 131,726 132,541 133,010 132,215 133,562 135,140 136,419 138,469 139,200 142,680 144,007 147,024
Esophagus 11,917 12,232 12,529 12,700 12,860 13,023 13,499 13,685 13,592 13,714 13,908 14,490 14,446 14,649
Stomach 12,711 12,645 12,319 12,198 12,110 11,859 11,514 11,345 11,388 11,352 11,184 11,390 11,035 11,191
Small intestine 1,036 1,057 1,082 1,017 1,070 1,115 1,117 1,091 1,083 1,192 1,195 1,218 1,256 1,293
Colon and rectum 57,222 57,434 56,808 56,603 55,783 53,580 53,005 53,196 53,219 52,857 51,848 52,045 51,783 51,516
Colon excluding rectum 48,962 49,019 48,292 47,987 47,248 44,988 44,325 44,331 44,247 43,650 42,471 42,245 42,181 41,867
Rectum and rectosigmoid junction 8,260 8,415 8,516 8,616 8,535 8,592 8,680 8,865 8,972 9,207 9,377 9,800 9,602 9,649
Anus, anal canal, and anorectum 462 492 511 539 555 589 583 623 644 718 818 813 863 889
Liver and intrahepatic bile duct 12,382 12,916 13,351 14,047 14,706 15,321 16,075 16,525 17,146 18,213 19,352 20,304 21,608 22,972
Gallbladder 2,059 1,949 1,971 1,907 1,915 1,936 1,989 2,000 1,914 1,971 2,048 2,105 2,101 2,102
Other biliary 1,531 1,717 1,630 1,501 1,491 1,461 1,464 1,427 1,436 1,377 1,384 1,519 1,510 1,519
Pancreas 29,081 29,331 29,802 30,263 30,777 31,771 32,759 33,454 34,117 35,234 35,628 36,888 37,344 38,797
Retroperitoneum 220 262 220 219 191 219 238 190 204 226 186 202 219 207
Peritoneum, omentum, and mesentery 429 503 543 616 602 686 648 698 721 695 703 702 807 750
Other digestive organs 1,020 917 960 931 950 655 671 906 955 920 946 1,004 1,035 1,139
Respiratory system 156,708 160,051 160,602 162,148 162,589 162,400 163,751 163,134 163,065 163,141 162,492 162,730 161,376 161,851
Nose, nasal cavity, and middle ear 456 419 485 444 457 458 484 426 475 516 530 495 416 458
Larynx 3,815 3,861 3,797 3,722 3,791 3,668 3,796 3,821 3,634 3,760 3,630 3,691 3,732 3,662
Lung and bronchus 152,061 155,426 155,969 157,630 157,990 158,006 159,217 158,599 158,683 158,592 158,081 158,248 156,953 157,423
Pleura 99 76 84 73 76 78 67 64 48 54 55 54 61 82
Trachea, mediastinum, and other respiratory organs 277 269 267 279 275 190 187 224 225 219 196 242 214 226
Bones and joints 1,224 1,212 1,298 1,194 1,262 1,301 1,391 1,340 1,362 1,357 1,384 1,378 1,423 1,399
Soft tissue including heart 3,679 3,693 3,646 3,554 3,651 3,722 3,849 3,960 4,023 4,093 4,229 4,376 4,408 4,559
Skin excluding basal and squamous 9,530 9,672 9,992 9,904 10,214 10,301 10,798 11,068 11,234 11,337 12,130 12,089 12,212 12,463
Melanoma of the skin 7,215 7,420 7,542 7,513 7,818 7,952 8,345 8,441 8,461 8,623 9,199 9,154 9,128 9,251
Other nonepithelial skin 2,315 2,252 2,450 2,391 2,396 2,349 2,453 2,627 2,773 2,714 2,931 2,935 3,084 3,212
Male and female breast 41,528 42,300 41,809 41,883 41,998 41,316 41,491 41,209 40,969 41,026 41,076 41,435 41,374 41,555
Female breast 41,144 41,872 41,394 41,514 41,619 40,954 41,116 40,820 40,598 40,589 40,676 40,996 40,931 41,150
Male breast 384 428 415 369 379 362 375 389 371 437 400 439 443 405
Female genital system 25,881 26,411 26,838 27,091 27,011 27,049 27,259 27,848 27,739 27,813 27,817 28,770 29,027 29,405
Cervix 4,204 4,200 4,092 3,952 3,919 3,850 3,924 3,976 4,021 4,008 3,909 3,939 4,092 4,074
Corpus and uterus, NOS 6,468 6,585 6,783 6,853 6,899 6,990 7,096 7,384 7,456 7,675 7,713 8,402 8,641 8,911
Corpus 3,121 3,139 3,185 3,187 3,261 3,272 3,259 3,449 3,377 3,436 3,333 3,644 3,714 3,812
Uterus, NOS 3,347 3,446 3,598 3,666 3,638 3,718 3,837 3,935 4,079 4,239 4,380 4,758 4,927 5,099
Ovary 13,627 14,060 14,414 14,682 14,657 14,716 14,787 14,857 14,621 14,362 14,436 14,572 14,346 14,404
Vagina 403 405 382 378 391 416 382 396 376 417 398 423 428 429
Vulva 762 752 765 794 775 806 809 862 865 921 946 942 1,022 1,034
Other female genital organs 417 409 402 432 370 271 261 373 400 430 415 492 498 553
Male genital system 32,349 31,675 31,300 31,084 30,176 29,627 29,514 29,022 29,703 29,120 28,744 29,276 28,630 27,955
Prostate 31,728 31,078 30,719 30,446 29,554 29,002 28,905 28,372 29,093 28,471 28,088 28,560 27,970 27,244
Testis 378 338 335 393 344 357 359 358 326 358 376 399 380 386
Penis 202 217 205 209 250 231 217 245 246 246 234 258 239 273
Other male genital organs 41 42 41 36 28 37 33 47 38 45 46 59 41 52
Urinary system 23,666 24,344 24,910 25,443 25,422 25,928 26,404 26,649 27,319 27,682 27,941 28,726 29,317 29,594
Urinary bladder 11,910 12,002 12,225 12,627 12,483 13,030 13,253 13,474 13,843 14,036 14,201 14,730 15,014 15,245
Kidney and renal pelvis 11,116 11,736 12,078 12,165 12,286 12,313 12,517 12,379 12,703 12,895 12,995 13,219 13,559 13,518
Ureter 345 302 294 297 323 334 347 361 340 354 371 350 338 378
Other urinary organs 295 304 313 354 330 251 287 435 433 397 374 427 406 453
Eye and orbit 227 236 226 240 231 208 252 219 249 262 278 283 280 279
Brain and other nervous system 12,765 12,655 12,609 12,830 12,901 12,829 13,152 12,886 13,234 13,724 14,176 14,164 14,491 15,276
Endocrine system 2,146 2,210 2,299 2,231 2,155 2,272 2,354 2,404 2,488 2,555 2,634 2,641 2,689 2,660
Thyroid 1,241 1,328 1,354 1,367 1,312 1,409 1,462 1,518 1,562 1,649 1,707 1,686 1,747 1,690
Other endocrine including thymus 905 882 945 864 843 863 892 886 926 906 927 955 942 970
Lymphomas 24,205 24,016 23,628 23,262 22,822 22,214 22,145 21,920 21,799 21,539 21,639 21,525 21,485 21,518
Hodgkin lymphoma 1,403 1,287 1,323 1,352 1,347 1,276 1,272 1,327 1,271 1,171 1,250 1,231 1,168 1,130
Non-Hodgkin lymphoma 22,802 22,729 22,305 21,910 21,475 20,938 20,873 20,593 20,528 20,368 20,389 20,294 20,317 20,388
Myeloma 10,508 10,639 10,714 10,913 10,809 10,578 10,758 10,712 10,872 10,606 10,690 11,022 11,411 11,821
Leukemias 21,071 21,397 21,532 21,581 21,608 21,472 21,716 22,016 21,928 22,431 22,688 22,673 23,194 23,309
Acute lymphocytic leukemia 1,361 1,395 1,433 1,432 1,429 1,371 1,460 1,393 1,418 1,424 1,423 1,436 1,432 1,408
Chronic lymphocytic leukemia 4,476 4,323 4,386 4,443 4,476 4,342 4,391 4,498 4,471 4,395 4,557 4,486 4,608 4,598
Acute myeloid leukemia 6,932 7,413 7,749 7,914 8,126 8,214 8,267 8,539 8,568 8,962 9,223 9,150 9,491 9,484
Chronic myeloid leukemia 1,788 1,802 1,649 1,367 1,233 1,164 1,067 1,077 984 1,000 1,003 1,019 1,091 1,017
Other leukemias 6,514 6,464 6,315 6,425 6,344 6,381 6,531 6,509 6,487 6,650 6,482 6,582 6,572 6,802
Mesothelioma 2,343 2,384 2,371 2,430 2,476 2,504 2,553 2,452 2,432 2,538 2,606 2,574 2,651 2,686
Miscellaneous 44,401 41,176 40,519 41,144 40,723 40,070 40,534 40,140 39,920 39,700 39,926 39,886 40,002 40,276

Abbreviation: NOS = not otherwise specified.
*Data are from the National Vital Statistics System (NVSS). Data for deaths cover 100% of the U.S. population. Use caution when comparing numbers of cases and deaths because of potential differences in population coverage. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Return to your place in the textTABLE 15. Age-adjusted rate* of invasive cancer cases, by primary cancer site and year — United States, 1999–2012§
Cancer site 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
All cancer sites combined 483.9 485.1 487.2 483.7 473.1 471.6 470.9 473.4 476.5 471.8 466.0 453.2 450.9 433.7
Oral cavity and pharynx 10.9 10.8 10.8 10.8 10.8 10.8 10.7 10.8 11.1 11.3 11.2 11.2 11.4 11.2
Lip 1.0 0.9 0.9 0.9 0.8 0.7 0.7 0.7 0.7 0.6 0.6 0.6 0.6 0.5
Tongue 2.6 2.7 2.7 2.8 2.8 2.9 2.9 3.0 3.1 3.3 3.3 3.2 3.4 3.4
Salivary gland 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.2 1.2 1.3
Floor of mouth 0.8 0.8 0.8 0.8 0.7 0.7 0.6 0.7 0.6 0.6 0.6 0.6 0.6 0.5
Gum and other mouth 1.7 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.6 1.6 1.5 1.6 1.6 1.5
Nasopharynx 0.6 0.6 0.5 0.6 0.6 0.6 0.6 0.5 0.6 0.6 0.5 0.5 0.5 0.5
Tonsil 1.4 1.4 1.4 1.5 1.6 1.6 1.6 1.7 1.7 1.8 2.0 1.9 2.0 2.0
Oropharynx 0.4 0.4 0.4 0.4 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
Hypopharynx 0.9 0.8 0.8 0.8 0.8 0.8 0.7 0.7 0.7 0.7 0.7 0.6 0.6 0.6
Other oral cavity and pharynx 0.4 0.4 0.4 0.3 0.3 0.3 0.3 0.2 0.3 0.3 0.2 0.3 0.3 0.3
Digestive system 91.8 91.6 91.2 90.1 89.7 88.7 87.3 86.3 85.6 84.8 82.9 80.7 80.1 78.4
Esophagus 5.0 5.0 5.0 4.9 5.0 5.1 5.0 5.0 4.9 5.0 4.9 4.6 4.6 4.5
Stomach 7.6 7.5 7.4 7.3 7.3 7.2 7.0 6.8 6.8 6.7 6.6 6.8 6.7 6.6
Small intestine 1.7 1.7 1.8 1.8 1.9 2.0 2.0 2.1 2.1 2.2 2.2 2.3 2.3 2.3
Colon and rectum 56.4 56.0 55.1 53.8 52.6 51.0 49.6 48.1 46.9 45.7 43.4 41.3 40.4 38.8
Colon excluding rectum 41.1 40.9 40.4 39.4 38.5 37.3 36.0 35.0 34.1 33.2 31.3 29.7 29.0 27.7
Rectum and rectosigmoid junction 15.2 15.1 14.8 14.4 14.1 13.8 13.6 13.1 12.8 12.5 12.1 11.6 11.4 11.1
Anus, anal canal, and anorectum 1.4 1.4 1.4 1.4 1.5 1.6 1.6 1.6 1.7 1.7 1.8 1.7 1.8 1.8
Liver and Intrahepatic bile duct 4.9 5.2 5.2 5.4 5.6 5.9 6.1 6.3 6.8 7.0 7.4 7.4 7.6 7.8
Gallbladder 1.2 1.2 1.2 1.1 1.2 1.1 1.2 1.2 1.1 1.1 1.2 1.2 1.1 1.1
Other biliary 1.3 1.4 1.6 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.8 1.8 1.8 1.7
Pancreas 11.1 11.2 11.3 11.2 11.5 11.6 11.8 12.0 12.0 12.3 12.2 12.3 12.4 12.4
Retroperitoneum 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4
Peritoneum, omentum, and mesentery 0.4 0.5 0.5 0.6 0.6 0.7 0.6 0.6 0.7 0.7 0.6 0.6 0.6 0.6
Other digestive organs 0.3 0.3 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.5 0.5
Respiratory system 76.3 75.6 75.4 74.9 74.7 73.9 74.0 73.1 72.1 71.3 69.9 67.5 65.8 64.0
Nose, nasal cavity, and middle ear 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7
Larynx 4.6 4.5 4.4 4.1 4.1 4.1 4.0 3.9 3.9 3.8 3.7 3.6 3.5 3.3
Lung and bronchus 70.7 70.1 70.1 69.9 69.7 68.8 69.1 68.2 67.3 66.6 65.3 62.9 61.5 59.8
Pleura 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Trachea, mediastinum, and other respiratory organs 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Bones and joints 1.0 0.9 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.9 1.0 0.9 0.9 0.9
Soft tissue including heart 2.9 3.0 3.0 3.0 3.1 3.2 3.3 3.2 3.3 3.3 3.3 3.3 3.2 3.2
Skin excluding basal and squamous 16.6 17.7 18.7 19.1 18.9 19.8 21.0 20.7 21.1 21.6 21.9 21.5 21.9 21.7
Melanoma of the skin 15.3 16.2 17.2 17.6 17.4 18.2 19.4 19.1 19.5 19.9 20.2 19.8 20.2 20.1
Other nonepithelial skin 1.3 1.4 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.7 1.7 1.6 1.6 1.6
Male and female breast 74.3 72.7 72.3 70.6 66.9 66.1 65.7 66.0 66.7 67.2 67.6 65.3 66.3 65.7
Female breast 135.2 132.8 132.3 129.3 122.9 121.5 121.0 121.9 123.2 124.4 125.3 121.2 123.2 122.3
Male breast 1.4 1.3 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.3 1.4 1.3 1.3
Female genital system 51.9 51.6 51.4 50.4 49.0 48.9 49.1 49.1 49.3 49.6 49.9 49.0 49.1 48.9
Cervix 9.7 9.6 9.1 8.7 8.4 8.2 8.2 8.1 8.1 7.9 8.0 7.6 7.5 7.4
Corpus and uterus, NOS 24.2 23.8 24.3 24.0 23.2 23.8 24.0 24.2 24.5 24.9 25.4 25.4 25.7 25.8
Corpus 23.4 23.1 23.6 23.3 22.5 23.0 23.3 23.4 23.8 24.1 24.6 24.6 24.9 25.0
Uterus, NOS 0.8 0.8 0.8 0.8 0.8 0.7 0.7 0.7 0.7 0.8 0.8 0.8 0.8 0.8
Ovary 14.3 14.4 14.2 13.8 13.6 13.2 13.1 13.0 12.7 12.7 12.2 11.8 11.6 11.3
Vagina 0.7 0.8 0.7 0.7 0.7 0.7 0.6 0.7 0.7 0.7 0.7 0.7 0.7 0.7
Vulva 2.4 2.3 2.4 2.4 2.4 2.3 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.6
Other female genital organs 0.6 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.8 0.9 0.9 1.0 1.1 1.2
Male genital system 176.5 178.4 180.6 178.4 163.7 159.7 156.4 166.0 170.1 157.0 148.7 139.2 137.5 111.7
Prostate 170.0 171.9 174.1 172.0 157.1 153.1 149.7 159.5 163.4 150.1 142.0 132.5 130.9 105.1
Testis 5.3 5.4 5.4 5.3 5.5 5.5 5.6 5.5 5.5 5.7 5.6 5.6 5.5 5.5
Penis 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.9 0.9 0.8 0.8 0.9 0.8
Other male genital organs 0.2 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.3 0.2 0.2 0.2 0.2
Urinary system 35.2 35.7 36.1 36.6 37.1 37.8 38.2 38.1 38.5 38.7 38.4 37.5 37.4 37.1
Urinary bladder 22.0 22.1 21.9 22.0 22.0 22.2 22.2 21.5 21.7 21.5 21.3 20.9 20.7 20.4
Kidney and renal pelvis 12.3 12.7 13.3 13.7 14.3 14.7 15.2 15.7 16.0 16.2 16.2 15.8 15.8 15.9
Ureter 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6
Other urinary organs 0.3 0.3 0.3 0.2 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3
Eye and orbit 0.9 0.9 0.9 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8
Brain and other nervous system 6.9 6.9 6.8 6.9 6.8 6.9 6.9 6.8 6.8 6.8 6.8 6.6 6.5 6.4
Brain 6.4 6.4 6.3 6.4 6.3 6.4 6.4 6.4 6.4 6.4 6.3 6.2 6.1 6.0
Cranial nerves other nervous system 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.4 0.5 0.5 0.5 0.4 0.4 0.4
Endocrine system 7.5 8.1 8.6 9.2 9.6 10.4 11.2 11.8 12.7 13.7 14.3 14.5 14.7 15.2
Thyroid 6.8 7.4 7.9 8.5 8.9 9.6 10.5 11.1 11.9 12.9 13.6 13.7 14.0 14.5
Other endocrine including thymus 0.7 0.7 0.7 0.7 0.7 0.8 0.8 0.8 0.8 0.8 0.7 0.8 0.7 0.7
Lymphomas 22.2 22.1 22.2 22.4 22.6 22.9 22.9 22.6 22.6 22.7 22.6 22.4 21.8 21.3
Hodgkin lymphoma 2.8 2.9 2.8 2.9 2.8 2.9 2.9 2.9 2.9 2.9 2.8 2.8 2.7 2.6
Non-Hodgkin lymphoma 19.3 19.2 19.4 19.5 19.8 20.1 19.9 19.7 19.8 19.7 19.8 19.5 19.0 18.6
Myeloma 5.6 5.8 5.9 5.9 5.9 6.0 6.0 5.9 5.9 6.1 6.2 6.3 6.3 6.3
Leukemias 12.9 13.4 13.5 13.1 13.4 13.4 13.3 13.4 13.2 13.2 13.2 13.6 13.5 13.3
Acute lymphocytic leukemia 1.4 1.5 1.5 1.5 1.5 1.6 1.5 1.6 1.6 1.6 1.6 1.6 1.7 1.6
Chronic lymphocytic leukemia 4.1 4.5 4.6 4.6 4.7 4.8 4.8 4.8 4.6 4.6 4.5 4.4 4.4 4.3
Acute myeloid leukemia 3.7 3.9 3.9 3.7 3.8 3.7 3.6 3.7 3.6 3.7 3.7 4.1 4.1 4.1
Chronic myeloid leukemia 1.6 1.7 1.7 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.7 1.8 1.7 1.7
Other leukemias 1.9 1.9 1.9 1.8 1.8 1.7 1.7 1.7 1.8 1.7 1.7 1.8 1.7 1.6
Mesothelioma 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 1.0
Kaposi Sarcoma 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.4 0.4 0.4 0.4 0.4
Miscellaneous 12.6 12.4 12.1 11.8 11.2 10.9 10.7 10.5 10.3 10.1 9.8 9.9 9.6 9.4

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Return to your place in the textFIGURE 4. Age-adjusted rate* of invasive cancer cases by primary cancer site, race,§ and sex — United States, 1999–2012
This figure presents 11 line charts showing, by race and sex, the age-adjusted rate per 100,000 persons of invasive cancer cases in the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by race for male prostate cancer and female breast cancer.

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Rates are not presented for persons of unknown or other race. Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Return to your place in the textFIGURE 5. Age-adjusted rate* of invasive cancer cases, by primary cancer site, ethnicity,§ and sex — United States, 1999–2012
This figure presents 11 line charts showing, by ethnicity (Hispanic and non-Hispanic) and sex, the age-adjusted rate per 100,000 population of invasive cancer cases in the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by ethnicity for male prostate cancer and female breast cancer.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Data for specified ethnical populations should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Return to your place in the textTABLE 16. Age-adjusted rate* of cancer deaths, by primary cancer site and year — United States, 1999–2012
Cancer site 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
All cancer sites combined 200.7 198.8 196.3 194.4 190.9 186.8 185.2 182.0 179.3 176.3 173.4 171.8 168.7 166.4
Oral cavity and pharynx 2.7 2.7 2.7 2.7 2.6 2.6 2.5 2.5 2.5 2.5 2.4 2.5 2.5 2.5
Lip 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Tongue 0.6 0.6 0.6 0.7 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6
Salivary gland 0.2 0.2 0.2 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Floor of mouth 0.1 0.1 0 0.1 0 0 0 0 0 0 0 0 0 0
Gum and other mouth 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.3 0.4 0.4 0.4
Nasopharynx 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Tonsil 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Oropharynx 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Hypopharynx 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Other oral cavity and pharynx 0.5 0.6 0.6 0.5 0.6 0.5 0.5 0.5 0.5 0.5 0.4 0.4 0.5 0.4
Digestive system 47.5 47.3 46.7 46.2 45.6 44.5 44.1 43.8 43.3 43.0 42.3 42.3 41.8 41.6
Esophagus 4.3 4.4 4.4 4.4 4.4 4.4 4.4 4.4 4.3 4.2 4.2 4.3 4.2 4.1
Stomach 4.6 4.5 4.4 4.3 4.2 4.0 3.8 3.7 3.6 3.5 3.4 3.4 3.3 3.2
Small intestine 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.3 0.4 0.4 0.4 0.4 0.4
Colon and rectum 20.9 20.7 20.2 19.8 19.1 18.1 17.6 17.3 16.9 16.5 15.8 15.5 15.1 14.7
Colon excluding rectum 17.9 17.6 17.1 16.8 16.2 15.2 14.7 14.4 14.1 13.6 13.0 12.6 12.3 12.0
Rectum and rectosigmoid junction 3.0 3.0 3.0 3.0 2.9 2.9 2.9 2.9 2.8 2.9 2.8 2.9 2.8 2.7
Anus, anal canal, and anorectum 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.3
Liver and intrahepatic bile duct 4.5 4.6 4.7 4.9 5.0 5.1 5.3 5.3 5.4 5.6 5.8 5.9 6.1 6.3
Gallbladder 0.8 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.6 0.6 0.6 0.6 0.6 0.6
Other biliary 0.6 0.6 0.6 0.5 0.5 0.5 0.5 0.5 0.5 0.4 0.4 0.5 0.4 0.4
Pancreas 10.6 10.5 10.6 10.6 10.5 10.7 10.8 10.9 10.8 11.0 10.8 11.0 10.9 11.0
Retroperitoneum 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Peritoneum, omentum, and mesentery 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Other digestive organs 0.4 0.3 0.3 0.3 0.3 0.2 0.2 0.3 0.3 0.3 0.3 0.3 0.3 0.3
Respiratory system 57.1 57.5 57.0 56.6 55.8 54.8 54.3 53.2 52.1 51.0 49.7 48.7 47.3 46.2
Nose, nasal cavity, and middle ear 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.2 0.1 0.1 0.1
Larynx 1.4 1.4 1.3 1.3 1.3 1.2 1.2 1.2 1.1 1.2 1.1 1.1 1.1 1.0
Lung and bronchus 55.4 55.8 55.3 55.0 54.2 53.4 52.9 51.7 50.7 49.6 48.4 47.4 46.0 45.0
Pleura 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Trachea, mediastinum, and other respiratory organs 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Bones and joints 0.4 0.4 0.5 0.4 0.4 0.4 0.5 0.4 0.4 0.4 0.4 0.4 0.4 0.4
Soft tissue including heart 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3
Skin excluding basal and squamous 3.5 3.5 3.5 3.4 3.5 3.5 3.6 3.6 3.6 3.5 3.7 3.6 3.6 3.6
Melanoma of the skin 2.6 2.7 2.7 2.6 2.7 2.7 2.8 2.7 2.7 2.7 2.8 2.7 2.7 2.7
Other nonepithelial skin 0.8 0.8 0.9 0.8 0.8 0.8 0.8 0.8 0.9 0.8 0.9 0.9 0.9 0.9
Male and female breast 15.2 15.2 14.8 14.5 14.3 13.8 13.6 13.2 12.9 12.7 12.4 12.3 12.0 11.8
Female breast 26.6 26.6 26.0 25.6 25.3 24.5 24.1 23.6 23.0 22.6 22.2 21.9 21.5 21.3
Male breast 0.3 0.4 0.4 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3
Female genital system 16.7 16.7 16.8 16.7 16.4 16.2 16.0 16.1 15.8 15.5 15.2 15.5 15.3 15.2
Cervix 2.8 2.8 2.7 2.6 2.5 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3
Corpus and uterus, NOS 4.1 4.1 4.2 4.2 4.1 4.1 4.1 4.2 4.2 4.2 4.2 4.5 4.5 4.5
Corpus 2.0 2.0 2.0 1.9 2.0 1.9 1.9 2.0 1.9 1.9 1.8 1.9 1.9 1.9
Uterus, NOS 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.4 2.5 2.6 2.6
Ovary 8.8 8.9 9.0 9.0 8.9 8.8 8.7 8.6 8.3 8.0 7.9 7.8 7.5 7.4
Vagina 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Vulva 0.5 0.4 0.5 0.5 0.4 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
Other female genital organs 0.3 0.3 0.3 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.3 0.3 0.3
Male genital system 32.1 30.9 30.0 29.2 27.7 26.7 25.8 24.7 24.7 23.5 22.6 22.3 21.2 20.0
Prostate 31.6 30.4 29.5 28.7 27.2 26.2 25.4 24.2 24.2 23.0 22.1 21.8 20.8 19.6
Testis 0.3 0.2 0.2 0.3 0.2 0.3 0.2 0.2 0.2 0.2 0.3 0.3 0.3 0.3
Penis 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Other male genital organs 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Urinary system 8.7 8.8 8.8 8.9 8.7 8.8 8.8 8.7 8.7 8.6 8.5 8.6 8.6 8.5
Urinary bladder 4.4 4.3 4.3 4.4 4.3 4.4 4.4 4.4 4.4 4.4 4.4 4.4 4.4 4.4
Kidney and renal pelvis 4.1 4.2 4.3 4.2 4.2 4.1 4.1 4.0 4.0 4.0 3.9 3.9 3.9 3.8
Ureter 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Other urinary organs 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Eye and orbit 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Brain and other nervous system 4.6 4.5 4.4 4.5 4.4 4.3 4.3 4.2 4.2 4.3 4.3 4.2 4.3 4.4
Endocrine system 0.8 0.8 0.8 0.8 0.7 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8
Thyroid 0.5 0.5 0.5 0.5 0.4 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
Other endocrine including thymus 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3
Lymphomas 8.8 8.6 8.4 8.1 7.8 7.5 7.4 7.2 7.0 6.8 6.7 6.5 6.4 6.2
Hodgkin lymphoma 0.5 0.5 0.5 0.5 0.5 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.3
Non-Hodgkin lymphoma 8.3 8.2 7.9 7.7 7.4 7.1 6.9 6.7 6.6 6.4 6.3 6.1 6.0 5.9
Myeloma 3.8 3.8 3.8 3.8 3.7 3.6 3.6 3.5 3.5 3.3 3.3 3.3 3.4 3.4
Leukemias 7.7 7.7 7.6 7.5 7.4 7.3 7.3 7.2 7.1 7.1 7.1 6.9 6.9 6.8
Acute lymphocytic leukemia 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.4 0.4
Chronic lymphocytic leukemia 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3
Acute myeloid leukemia 2.5 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.8 2.8 2.8
Chronic myeloid leukemia 0.7 0.6 0.6 0.5 0.4 0.4 0.4 0.4 0.3 0.3 0.3 0.3 0.3 0.3
Other leukemias 2.4 2.3 2.2 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.0 2.0 2.0 2.0
Mesothelioma 0.9 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.8 0.8 0.8
Miscellaneous 16.2 14.8 14.4 14.4 14.0 13.5 13.4 13.0 12.7 12.4 12.2 11.9 11.7 11.5

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25-1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS). Data for deaths cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Return to your place in the textFIGURE 6. Age-adjusted rate* of cancer deaths, by primary cancer site, race, and sex — United States, 1999–2012§
The figure presents 11 line charts showing, by race and sex, age-adjusted death rates per 100,000 population for the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by race for male prostate cancer and female breast cancer.

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander.

* Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Rates are not presented for persons of unknown or other race. Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

§ Data are from the National Vital Statistics System (NVSS). Data for death rates cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Return to your place in the textFIGURE 7. Age-adjusted rate* of cancer deaths, by primary cancer site, ethnicity, and sex — United States, 1999–2012§
The figure presents 11 line charts showing, by ethnicity (Hispanic and non-Hispanic) and sex, age-adjusted death rates per 100,000 population for the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by ethnicity for male prostate cancer and female breast cancer.

* Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Data for specified ethnic populations should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

§ Data are from the National Vital Statistics System (NVSS). Data for death rates cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

Suggested citation for this article: Singh SD, Henley SJ, Ryerson AB. Surveillance for Cancer Incidence and Mortality — United States, 2012. MMWR Morb Mortal Wkly Rep 2016;63:17–58. DOI: http://dx.doi.org/10.15585/mmwr.mm6355a4.

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