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Surveillance for Cancer Incidence and Mortality — United States, 2012



Simple D. Singh, MD1; S. Jane Henley, MSPH1; A. Blythe Ryerson, PhD1 (View author affiliations)

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Preface

This report provides, in tabular and graphic form, official federal statistics on the occurrence of cancer for 2012 and trends for 1999–2012 as reported by CDC and the National Cancer Institute (NCI) (1). Cancer incidence data are from population-based cancer registries that participate in CDC’s National Program of Cancer Registries (NPCR) and NCI’s Surveillance, Epidemiology, and End Results (SEER) program reported as of November 2014. Cancer mortality data are from death certificate information reported to state vital statistics offices through 2012 and compiled into a national file for the entire United States by CDC’s National Center for Health Statistics’ (NCHS) National Vital Statistics System (NVSS). This report is a part of the Summary of Notifiable Noninfectious Conditions and Disease Outbreaks — United States, which encompasses various surveillance years but is being published in 2016 (2). The Summary of Notifiable Noninfectious Conditions and Disease Outbreaks appears in the same volume of MMWR as the annual Summary of Notifiable Infectious Diseases (3).

This report presents information on new cancer cases and deaths for 2012. The number and rate of cancer cases and deaths are stratified by the primary cancer sites as reported for 2012; information is provided by demographic characteristic (e.g., sex, age, race, and ethnicity) and primary cancer site (68 selected sites among men and 72 selected sites among women). Age-adjusted cancer incidence and death rates are shown by primary site and year for the period 1999–2012. Age-adjusted cancer incidence and death rates for the most common sites are shown by race, sex, and ethnicity for 2012, the most recent year for which incidence data are available. Maps of the United States display age-adjusted cancer incidence and death rates, presented by quartiles, for 2012. Time trends in age-adjusted cancer incidence and death rates during 1999–2012 are shown by race, sex, and ethnicity for all sites combined, colorectal, lung and bronchus, prostate, and female breast.

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Background

Cancer comprises a diverse mix of diseases occurring in every part of the body and is a leading cause of death in the United States (4). More than half of cancer cases could be prevented (5). Surveillance of cancer incidence and mortality can help public health officials target areas for control efforts (6) and track progress toward meeting the national health objectives set forth in Healthy People 2020 (7). Cancer is a reportable disease in every state and thus all hospitals, physicians’ offices, pathology laboratories, and other medical facilities are required to submit data on all reportable cancer diagnoses to a central cancer registry at the state or territorial level. A cancer registry is a database that contains individual records of all reportable cancer cases in a defined population and includes patient demographics, tumor characteristics (e.g., cancer site and pathology), and information about the notifying health provider or facility. In 1992, Congress established NPCR by enacting the Cancer Registries Amendment Act (Public Law 102-515) (8). Administered by CDC, NPCR collects data on the occurrence of cancer and the type, extent, and location of the cancer. Before NPCR was established, 10 states had no registry, and most states with registries lacked the resources and state legislation needed to gather complete data (9). Presently, NPCR supports central cancer registries in 45 states, the District of Columbia (DC), Puerto Rico, and the U.S. Pacific Island Jurisdictions. NPCR data represent 96% of the overall U.S. population. Together, NPCR and NCI’s SEER Program collect data for the entire U.S. population. Cancer control planners and others can identify variations in cancer rates by population subgroups and monitor trends over time to guide the planning and evaluation of cancer prevention and control programs and allocation of health resources.

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Data Sources

Data about cancer incidence and mortality in the Summary of Notifiable Noninfectious Conditions and Disease Outbreaks come from the official federal statistics on cancer, the U.S. Cancer Statistics (USCS) dataset (1). The USCS dataset includes cancer incidence data from NPCR registries in 45 states and DC (cancer incidence data from Puerto Rico and the U.S. Pacific Island Jurisdictions were not available for this analysis) and from SEER program registries in the remaining five states (Connecticut, Hawaii, Iowa, New Mexico, and Utah) and cancer mortality data from NVSS.

Incidence Data

The primary source of data on cancer incidence is medical records. Staff at health care facilities abstract data from patients' medical records, enter it into the facility’s own cancer registry if it has one, and then send the data to the regional or state registry. Both NPCR and SEER registries collect data using uniform data items and codes as documented by the North American Association of Central Cancer Registries (NAACCR). This uniformity ensures that data items collected by the two federal programs are comparable (10,11). Information on primary site and histology is coded according to the International Classification of Diseases for Oncology, Third Edition (ICD-O-3) and categorized according to the revised SEER recodes dated January 27, 2003, which define standard groupings of primary cancer sites (http://seer.cancer.gov/siterecode) (12). Beginning with 2010 diagnoses, cases were first classified by anatomic site using ICD-O-3; cases with hematopoetic histologies were further classified by using the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (13). Data from the NPCR registries provided in this report were reported to CDC as of November 30, 2014. Data from SEER registries were reported to NCI as of November 1, 2014.

NPCR and SEER cancer registries consider as reportable all incident cases with a behavior code of 2 (in situ, noninvasive) or 3 (malignant, primary site only) in ICD-O-3. Exceptions include in situ cancer of the cervix and all basal and squamous cell carcinomas of the skin, except for those on the skin of the genital organs (12). Beginning with 2001 diagnoses, several cancers that are coded as malignant in ICD-O-3 were not coded as malignant in ICD-O-2 (10). Additional information is provided in the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IncidenceDataSources).

Mortality Data

Cancer mortality statistics are based on information from all death certificates filed in the 50 states and DC and processed by NVSS at NCHS (14). The cancer mortality data were compiled in accordance with World Health Organization regulations, which specify that member nations classify and code causes of death in accordance with the current revision of the International Classification of Diseases (ICD) (15). For consistency with the data on cancer incidence, the cancer sites in mortality data were grouped according to the revised SEER recodes dated January 27, 2003 (available at http://seer.cancer.gov/codrecode). Data for a specific calendar year are based on records of deaths that occurred during that calendar year and received by a particular date; for example, mortality data for 2012 are based on records of deaths that occurred during 2012 and were received as of June 30, 2014. Additional information is provided in the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=MortalityDataSources).

Population Estimates

Population denominators are race-specific, ethnicity-specific, and sex-specific county population estimates from the U.S. Census, modified by SEER and aggregated to the state and national level. Additional details about population data are available at http://seer.cancer.gov/popdata/index.html.

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Interpreting Data

Incidence Data

Each year, state cancer registries submit cancer cases for a new diagnosis year and an updated version of the previous years’ cancer cases to CDC or NCI. Therefore, each year, when USCS data are published, updates to the previous year’s data are published, using the most recent data submission and the most recent population data. Users of cancer incidence data published by federal agencies should be mindful of the data submission dates for all data used in their analyses.

Mortality Data

Cancer mortality statistics in USCS are influenced by the accuracy of information on the death certificate. Unlike incidence data, mortality data for a calendar year are considered complete when submitted and so are not updated after the aggregate data file is released. Mortality data for the entire United States refer only to deaths that occurred within the United States; data for geographic areas are provided by the decedent’s place of residence.

Race and Ethnicity Data

For cancer incidence, race and ethnicity data are abstracted from medical records and grouped into categories (11). When cancer mortality is reported, race and ethnic origin are recorded separately on the death certificate by the funeral director as provided by an informant or, in the absence of an informant, on the basis of observation (16).

Differences in rates among racial and ethnic populations should be interpreted with caution. A study using SEER incidence data suggests that the quality of data on race in cancer registries is considered excellent for whites, blacks, and Asians/Pacific Islanders, good for Hispanics, and poor for American Indians/Alaska Natives (17). Previous studies involving cancer mortality data demonstrate that death rates for whites and blacks generally are estimated accurately whereas death rates for Asians/Pacific Islanders, American Indians/Alaska Natives, and Hispanics are underestimated (18). For this reason, incidence and mortality data provided in this report might be underestimated for these groups, possibly because of misclassification of race or Hispanic ethnicity.

Three NPCR registries (Delaware, Kentucky, and South Carolina) opted not to present state-specific Asian/Pacific Islander counts and rates. Five NPCR registries (Delaware, Kentucky, Massachusetts, Pennsylvania, and South Carolina) opted not to present state-specific Hispanic (classified by the NAACCR Hispanic Identification [NHIA] Algorithm) counts and rates (19). Cancer registries regularly link their database to the Indian Health Service patient registration dataset to reduce misclassification of race for American Indian/Alaska Native cases. Seven NPCR registries (Delaware, Illinois, Kansas, Kentucky, New Jersey, New York, and South Carolina) opted not to present state-specific American Indian/Alaska Native counts and rates. However, in each of these cases, the aggregate national rates presented in this report include data for these registries.

Methods for Identifying Cancer

Medical facilities such as hospitals, doctors’ offices, and pathology laboratories send information about cancer cases to their cancer registry. Most information comes from hospitals, where highly trained cancer registrars transfer the information from the patient’s medical record to the registry’s computer software using standardized codes. The data are then sent to the central cancer registry. Every year the central cancer registries electronically submit incidence, demographic, and clinical data to NPCR or SEER.

Population Coverage

The population coverage for incidence data varies by diagnosis year. Population coverage might be affected by the suppression of state incidence data, if a state did not meet the publication criteria or did not submit data. In addition, state incidence data might be suppressed if <16 cases were reported or if the state requested that the data be suppressed. Additional information is provided by the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=CensusRegionPubCriteria). Mortality data from malignant neoplasms (i.e., cancers) as recorded in the NVSS from the 50 states and DC are available in USCS, and thus 100% of the U.S. population is covered each year. However, state death data might be suppressed if <16 deaths were reported.

Suppression of Rates and Counts

When the numbers of cases or deaths used to compute rates are small, those rates tend to have poor reliability. Therefore, in an effort to discourage misinterpretation or use of rates or counts that are unstable because case or death counts are small, incidence and death rates and counts of <16 are not shown in tables and figures. The use of a threshold value for suppressing cells helps protect the confidentiality of patients by reducing or eliminating the risk for disclosure of their identity. Additional information is provided in the USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=Suppression).

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Publication Criteria

Cancer incidence data that appear in this report are derived from state cancer registries that have high-quality cancer incidence data for individual (e.g., 2012) and combined (e.g., 1999–2012) years as demonstrated by meeting all of the following criteria on data quality for all cancer sites combined:

  • case ascertainment is ≥90% (margin of error +5%) complete,

  • ≤5% of cases are ascertained solely on the basis of a death certificate,

  • ≤3% of cases are missing information on sex,

  • ≤3% of cases are missing information on age,

  • ≤5% of cases are missing information on race, and

  • ≥97% of the registry’s records passed a set of single-field and inter-field computerized edits that test the validity and logic of data components.

Additional information about USCS is available at http://www.cdc.gov/uscs/.

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Highlights

Incidence and Death Rates

In 2012, approximately 1.5 million invasive cancers were diagnosed in the United States, an annual incidence rate of 440 cases per 100,000 persons (Table 1). In the same year, approximately 582,600 persons died of cancer nationally, an annual death rate of 166 deaths per 100,000 persons (Table 2). By state, overall (all cancer sites combined) cancer incidence rates in 2012 ranged from 371 to 515 cases per 100,000 persons (Table 3), and overall cancer death rates ranged from 129 to 201 deaths per 100,000 persons (Table 4).

Cancer incidence (Table 5) and death (Table 6) rates increase with age. In 2012, among persons in the youngest age group (<15 years), 9,967 new cancer cases (rate: 17 cases per 100,000 persons) and 1,367 cancer deaths (rate: two deaths per 100,000 persons) were reported. Among persons aged ≥65 years, 826,841 new cancer cases (rate: 1,933 cases per 100,000 persons) and 403,497 cancer deaths (rate: 935 deaths per 100,000 persons) were reported. Overall, 54% of cancer cases and 69% of cancer deaths in 2012 occurred among persons aged ≥65 years.

Overall and for many cancer sites, males had higher incidence (Table 7) and death rates (Table 8) than did females. In 2012, blacks had the highest cancer incidence (Table 9) and death (Table 10) rates in the United States, and American Indians/Alaska Natives and Asians/Pacific Islanders had the lowest cancer incidence and death rates. Overall and for most cancer sites, Hispanics had lower cancer incidence (Table 11) and death rates (Table 12) than did non-Hispanics. Differences in cancer rates by race and ethnicity (Figure 1) might reflect differences in risk factors, screening, and treatment although rates among some populations might be underestimated because of problems ascertaining race or ethnicity.

By state and site, cancer incidence rates in 2012 ranged from 70 to 157 per 100,000 males for prostate cancer, 107 to 141 per 100,000 females for breast cancer, 4 to 10 per 100,000 females for cervical cancer, 29 to 92 per 100,000 persons for lung cancer, and 30 to 49 per 100,000 persons for colorectal cancer (Figure 2). By state and site, cancer death rates in 2012 ranged from 13 to 32 per 100,000 males for prostate cancer, 16 to 31 per 100,000 females for breast cancer, 1 to 5 per 100,000 females for cervical cancer, 20 to 69 per 100,000 persons for lung cancer, and 11 to 19 per 100,000 persons for colorectal cancer (Figure 3).

Differing rates of cancer by race, ethnicity, and state of residence indicate that for some populations, Healthy People 2020 objectives have already been achieved, whereas objectives for other populations have not been met and these populations might benefit from targeted cancer prevention and control efforts.

Four cancer sites accounted for 49% of all cases diagnosed in 2012, including 224,147 female breast cancers, 210,828 lung and bronchus cancers (111,395 among men and 99,433 among women), 177,489 prostate cancers, and 134,784 colon and rectum cancers (70,204 among men and 64,580 among women) (Table 13). These four sites also accounted for 48% of cancer deaths in 2012, including 157,423 lung cancer deaths, 51,516 colon and rectum cancer deaths, 41,150 female breast cancer deaths, and 27,244 prostate cancer deaths (Table 14).

Time Trends in Incidence and Death Rates

On the basis of data from registries meeting data quality criteria during 1999–2012, cancer incidence rates declined from 484 cancer cases per 100,000 population in 1999 to 434 cases in 2012 (Table 15). Although lung cancer incidence declined steadily among men from 1999 to 2012, it increased among women from 1999 to 2005 and has since declined from 2005 to 2012. Prostate cancer incidence declined from 170 cases per 100,000 men in 1999 to 105 cases in 2012. Colorectal cancer incidence declined from 56 cases per 100,000 persons in 1999 to 39 cases in 2012. Female breast cancer incidence declined from 135 cases per 100,000 women in 1999 to 121 cases in 2005, increased to 125 cases in 2009, and declined again to 122 cases in 2012. Time trends in cancer incidence rates are presented by cancer site, sex, and race (Figure 4) and by cancer site, sex, and ethnicity (Figure 5). During 1999–2012, cancer death rates declined from 201 deaths per 100,000 persons in 1999 to 166 deaths in 2012; during the same period, death rates declined for each of the four most common cancers (Table 16). Time trends in cancer death rates are presented by cancer site, sex, and race (Figure 6) and by cancer site, sex, and ethnicity (Figure 7).

National cancer surveillance data help public health officials track progress toward achieving the national cancer objectives set forth in Healthy People 2020 (20). For the national cancer burden to be reduced and Healthy People 2020 targets to be met, behavioral and environmental factors that increase cancer risk must be reduced, and high-quality screening services, timely follow-up, and evidence-based treatments must be available and accessible to all persons. Several effective primary and secondary prevention measures, such as vaccination against infectious agents that cause cancer (i.e., hepatitis B virus and human papillomavirus), help with smoking cessation, and cancer screening, when effectively implemented and sustained, could reduce the number of new cancer cases and prevent many cancer-related deaths (21). Evidence-based interventions can be implemented at both the individual level and the population level to reduce cancer risk factors, promote healthy living, and encourage cancer screening (5).

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Acknowledgments

Data were provided by state and regional cancer registry personnel.

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Corresponding author: Simple Singh, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC. Telephone: 770-488-4292; E-mail: sdsingh@cdc.gov.

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1Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC

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References

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  10. Fritz ARL. The SEER program code manual. Bethesda, MD: National Cancer Institute; 1998.
  11. Havener LTM, editor. Standards for cancer registries. Volume II: data standards and data dictionary. 13th ed. Version 11.3. Springfield, IL: North American Association of Central Cancer Registries; 2008.
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  13. National Cancer Institute. Hematopoietic codes based on WHO classification of tumours of haematopoietic and lymphoid tissues. Rockville, MD: US Department of Health and Human Services, National Cancer Institute; 2008. http://seer.cancer.gov/iccc
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  15. World Health Organization. International statistical classification of diseases and related health problems. 10th revision. Geneva, Switzerland: World Health Organization; 1992.
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  17. Clegg LX, Reichman ME, Hankey BF, et al. Quality of race, Hispanic ethnicity, and immigrant status in population-based cancer registry data: implications for health disparity studies. Cancer Causes Control 2007;18:177–87. CrossRef PubMed
  18. Arias E, Schauman WS, Eschbach K, Sorlie PD, Backlund E. The validity of race and Hispanic origin reporting on death certificates in the United States. Vital Health Stat 2 2008;(148):1–23. http://www.cdc.gov/nchs/data/series/sr_02/sr02_148.pdf PubMed
  19. NAACCR Asian Pacific Islander Work Group. NAACCR Asian Pacific Islander identification algorithm. Springfield, IL: North American Association of Central Cancer Registries; 2008.
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Return to your place in the textTABLE 1. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site — United States, 2012§
Cancer siteAll races/ethnicities
No.Rate
All cancer sites combined 1,529,078440.3
Oral cavity and pharynx39,87911.2
Lip1,8420.5
Tongue12,3743.4
Salivary gland4,2541.3
Floor of mouth1,9360.5
Gum and other mouth5,3311.5
Nasopharynx1,7580.5
Tonsil7,3302.0
Oropharynx1,7330.5
Hypopharynx2,2810.6
Other oral cavity and pharynx1,0400.3
Digestive system273,53578.3
Esophagus15,9934.5
Stomach22,6236.6
Small intestine7,8942.3
Colon and rectum134,78438.9
Colon excluding rectum95,96227.8
Rectum and rectosigmoid junction38,82211.1
Anus, anal canal, and anorectum6,3381.8
Liver and Intrahepatic bile duct28,0127.7
Gallbladder3,8351.1
Other biliary5,9631.7
Pancreas43,21312.3
Retroperitoneum1,3210.4
Peritoneum, omentum, and mesentery1,9240.5
Other digestive organs1,6350.5
Respiratory system225,93364.7
Nose, nasal cavity, and middle ear2,2740.7
Larynx12,1523.4
Lung and bronchus210,82860.4
Pleura1050
Trachea, mediastinum, and other respiratory organs5740.2
Bones and joints2,9510.9
Soft tissue including heart10,7283.2
Skin excluding basal and squamous73,18121.5
Melanoma of the skin67,75319.9
Other nonepithelial skin5,4281.6
Male and female breast 226,27265.6
Female breast224,147122.2
Male breast2,1251.4
Female genital system90,30348.8
Cervix12,0427.4
Corpus and uterus, NOS49,15425.7
Corpus47,57024.9
Uterus, NOS1,5840.8
Ovary20,78511.3
Vagina1,2960.7
Vulva4,8512.6
Other female genital organs2,1751.2
Male genital system187,308111.8
Prostate177,489105.3
Testis8,1895.5
Penis1,2830.8
Other male genital organs3470.2
Urinary system128,10337.0
Urinary bladder 69,97420.2
Kidney and renal pelvis55,23115.9
Ureter1,9180.6
Other urinary organs9800.3
Eye and orbit2,7330.8
Brain and other nervous system21,4906.5
Brain20,1516.0
Cranial nerves other nervous system1,3390.4
Endocrine system48,59415.0
Thyroid46,27914.3
Other endocrine including thymus2,3150.7
Lymphomas71,69221.1
Hodgkin lymphoma8,2732.6
Non-Hodgkin lymphoma63,41918.5
Myeloma21,8296.3
Leukemias44,39613.2
Acute lymphocytic leukemia4,8461.6
Chronic lymphocytic leukemia14,8214.2
Acute myeloid leukemia13,8204.1
Chronic myeloid leukemia5,5431.7
Other leukemias5,3661.6
Mesothelioma3,1990.9
Kaposi Sarcoma1,0760.3
Miscellaneous55,87616.3

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf.

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Return to your place in the textTABLE 2. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site — United States, 2012
Cancer siteAll races/ethnicities
No.Rate
All cancer sites combined 582,607166.4
Oral cavity and pharynx8,9242.5
Lip710
Tongue2,2240.6
Salivary gland8690.2
Floor of mouth750
Gum and other mouth1,2750.4
Nasopharynx6660.2
Tonsil8790.2
Oropharynx8910.2
Hypopharynx3560.1
Other oral cavity and pharynx1,6180.4
Digestive system147,02441.6
Esophagus14,6494.1
Stomach11,1913.2
Small intestine1,2930.4
Colon and rectum51,51614.7
Colon excluding rectum41,86712.0
Rectum and rectosigmoid junction9,6492.7
Anus, anal canal, and anorectum8890.3
Liver and intrahepatic bile duct22,9726.3
Gallbladder2,1020.6
Other biliary1,5190.4
Pancreas38,79711.0
Retroperitoneum2070.1
Peritoneum, omentum, and mesentery7500.2
Other digestive organs1,1390.3
Respiratory system161,85146.2
Nose, nasal cavity, and middle ear4580.1
Larynx3,6621.0
Lung and bronchus157,42345.0
Pleura820
Trachea, mediastinum, and other respiratory organs2260.1
Bones and joints1,3990.4
Soft tissue including heart4,5591.3
Skin excluding basal and squamous12,4633.6
Melanoma of the skin9,2512.7
Other nonepithelial skin3,2120.9
Male and female breast 41,55511.8
Female breast41,15021.3
Male breast4050.3
Female genital system29,40515.2
Cervix4,0742.3
Corpus and uterus, NOS8,9114.5
Corpus3,8121.9
Uterus, NOS5,0992.6
Ovary14,4047.4
Vagina4290.2
Vulva1,0340.5
Other female genital organs5530.3
Male genital system27,95520.0
Prostate27,24419.6
Testis3860.3
Penis2730.2
Other male genital organs520
Urinary system29,5948.5
Urinary bladder 15,2454.4
Kidney and renal pelvis13,5183.8
Ureter3780.1
Other urinary organs4530.1
Eye and orbit2790.1
Brain and other nervous system15,2764.4
Endocrine system2,6600.8
Thyroid1,6900.5
Other endocrine including thymus9700.3
Lymphomas21,5186.2
Hodgkin lymphoma1,1300.3
Non-Hodgkin lymphoma20,3885.9
Myeloma11,8213.4
Leukemias23,3096.8
Acute lymphocytic leukemia1,4080.4
Chronic lymphocytic leukemia4,5981.3
Acute myeloid leukemia9,4842.8
Chronic myeloid leukemia1,0170.3
Other leukemias6,8022.0
Mesothelioma2,6860.8
Miscellaneous40,27611.5

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see UCSC technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).

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Return to your place in the textTABLE 3. Reported number and age-adjusted rate* of invasive cancer cases, all cancer sites combined, by geographic division and area — United States, 2012§
AreaAll races/ethnicities
No.Rate
Northeast311,842474.3
New England81,778469.6
Connecticut20,371477.1
Maine8,417475.1
Massachusetts35,774463.1
New Hampshire7,576473.5
Rhode Island6,095484.0
Vermont3,545449.0
Middle Atlantic230,064476.1
New Jersey48,545477.7
New York105,941475.8
Pennsylvania75,578476.1
Midwest345,611448.8
East North Central237,817446.2
Illinois64,402459.0
Indiana31,852439.4
Michigan51,809444.5
Ohio59,848438.0
Wisconsin29,906447.7
West North Central107,794454.7
Iowa17,000463.4
Kansas14,614460.3
Minnesota27,833462.8
Missouri31,643450.6
Nebraska8,953432.6
North Dakota3,577450.5
South Dakota4,174434.3
South566,112434.9
South Atlantic307,360430.4
Delaware5,306483.5
District of Columbia2,954474.9
Florida105,651414.2
Georgia45,623459.6
Maryland27,870430.8
North Carolina48,367443.0
South Carolina24,737447.7
Virginia35,743403.1
West Virginia11,109461.3
East South Central100,201470.0
Alabama25,225451.0
Kentucky25,845515.1
Mississippi15,084457.4
Tennessee34,047459.4
West South Central158,551424.0
Arkansas15,259442.8
Louisiana24,062483.4
Oklahoma18,785442.8
Texas100,445406.2
West
Mountain
Arizona27,680373.4
Colorado21,614405.5
Idaho7,452437.0
Montana5,424434.4
Nevada
New Mexico8,726371.4
Utah9,582404.0
Wyoming2,516396.0
Pacific222,519418.1
Alaska2,601401.8
California158,944410.1
Hawaii6,802415.6
Oregon19,531422.2
Washington34,641460.1

*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
Rates and counts are not presented for the West Census Region, the Mountain Census Division, or Nevada because data from Nevada are not included in this analysis.

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Return to your place in the textTABLE 4. Reported cancer deaths and age-adjusted death rates,* all cancer sites combined, by geographic division and area — United States, 2012
AreaAll races/ethnicities
No.Rate
United States582,607166.4
Northeast110,175164.1
New England28,904162.6
Connecticut6,681152.0
Maine3,226179.0
Massachusetts12,864163.3
New Hampshire2,660167.7
Rhode Island2,148163.6
Vermont1,325164.8
Middle Atlantic81,271164.7
New Jersey16,483160.3
New York35,881159.5
Pennsylvania28,907174.8
Midwest135,511174.1
East North Central94,939176.9
Illinois24,562175.5
Indiana13,368184.2
Michigan20,496174.3
Ohio25,261182.1
Wisconsin11,252166.1
West North Central40,572167.8
Iowa6,438167.9
Kansas5,429167.7
Minnesota9,424155.6
Missouri12,919182.0
Nebraska3,479164.6
North Dakota1,253150.7
South Dakota1,630162.0
South221,435171.4
South Atlantic118,858165.8
Delaware1,935176.1
District of Columbia1,081178.4
Florida42,187157.8
Georgia16,020169.6
Maryland10,524166.0
North Carolina18,405170.5
South Carolina9,728179.0
Virginia14,294165.3
West Virginia4,684191.1
East South Central40,547192.0
Alabama10,274184.8
Kentucky10,012201.2
Mississippi6,496200.0
Tennessee13,765187.9
West South Central62,030170.5
Arkansas6,540188.6
Louisiana9,308190.5
Oklahoma8,040189.6
Texas38,142160.6
West115,486151.9
Mountain34,819147.7
Arizona11,085148.3
Colorado7,306143.7
Idaho2,572152.0
Montana1,954154.2
Nevada4,610163.8
New Mexico3,461148.0
Utah2,876128.7
Wyoming955154.6
Pacific80,667153.7
Alaska925169.0
California57,675151.0
Hawaii2,284134.6
Oregon7,832168.3
Washington11,951161.8

*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).

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Return to your place in the textTABLE 5. Reported number and rate* of invasive cancer cases, by primary cancer site and age group — United States, 2012§
Cancer siteAge group (yrs)Total
<1515–2425–3940–64≥65
No.RateNo.RateNo.RateNo.RateNo.RateNo.Rate (crude)
All cancer sites combined9,96716.512,6342958,70995.9620,927603826,8411,932.601,529,078491.5
Oral cavity and pharynx840.12590.61,1521.921,14020.517,24440.339,87912.8
Esophagus1270.26,3836.29,48022.215,9935.1
Stomach6491.18,1537.913,76432.222,6237.3
Colon and rectum340.13400.83,5265.851,74650.279,138185134,78443.3
Liver and intrahepatic bile duct2220.4780.22920.514,69814.312,72229.728,0129.0
Pancreas3910.614,17813.828,58566.843,21313.9
Larynx1070.25,9665.86,06814.212,1523.9
Lung and bronchus270990.28931.566,10564.2143,704335.9210,82867.8
Melanomas of the skin1070.28972.15,5079.028,90128.132,34175.667,75321.8
Female breast9,60531.5114,962218.799,396411.9224,147141.8
Cervix2,7959.26,73012.82,3689.812,0427.6
Corpus and uterus, NOS1,6165.326,34150.121,12987.649,15431.1
Ovary1020.33481.61,0713.59,56418.29,70040.220,78513.2
Prostate770.377,236153.2100,156536.9177,489115.9
Testis540.21,4256.44,07313.22,4404.81971.18,1895.3
Urinary bladder††200650.15480.918,01917.551,322120.069,97422.5
Kidney and renal pelvis5270.91800.41,9863.225,55724.826,98163.155,23117.8
Brain and nervous system2,1033.59682.22,0843.48,1277.98,20819.221,4906.9
Thyroid1970.32,0294.79,54515.624,87624.29,63222.546,27914.9
Hodgkin lymphoma3400.61,5993.72,2453.72,6142.51,4753.48,2732.7
Non-Hodgkin lymphoma5951.09332.12,8994.723,10122.435,89183.963,41920.4
Myeloma2660.47,8877.713,66331.921,8297.0
Leukemias2,9484.91,1632.72,2433.713,51713.124,52557.344,39614.3
Mesothelioma360.16660.62,4865.83,1991.0
Kaposi Sarcoma3210.54480.42690.61,0760.3

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
Counts and rates are suppressed if <16 cases were reported in a specific category. Some counts and rates are suppressed as complementary cell suppression.

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Return to your place in the textTABLE 6. Reported number and rate* of cancer deaths, by primary cancer site and age group — United States, 2012
Cancer siteAge group (yrs)Total (all ages)
<1515–2425–3940–64≥65
No.RateNo.RateNo.RateNo.RateNo.RateNo.Rate (crude)
All cancer sites combined1,3672.21,5743.67,39112168,778162.5403,497935.2582,607185.6
Oral cavity and pharynx§1280.23,6773.55,10011.88,9242.8
Esophagus740.15,3585.29,21321.414,6494.7
Stomach2710.43,5903.57,30916.911,1913.6
Colon and rectum7751.315,19914.635,48082.251,51616.4
Liver and intrahepatic bile duct320.1340.11860.39,8379.512,88329.922,9277.3
Pancreas1510.210,96210.627,67664.138,79712.4
Larynx1801,3741.32,2695.33,6621.2
Lung and bronchus4300.743,46341.8113,499263.1157,42350.2
Melanomas of the skin3000.53,1793.15,74613.39,2512.9
Female breast9713.216,10430.424,06298.941,15025.8
Cervix4371.42,2594.31,3695.64,0742.6
Corpus and uterus, NOS1080.42,8555.45,94424.48,9115.6
Ovary1760.64,8229.19,37838.614,4049.0
Prostate2,9625.824,271128.927,24417.6
Testis1310.41490.3510.33860.2
Urinary bladder350.12,3902.312,81429.715,2454.9
Kidney and renal pelvis300310.11090.24,1344.09,21421.413,5184.3
Brain and nervous system4580.72520.67441.26,1775.97,64517.715,2764.9
Thyroid2304500.41,2122.81,6900.5
Hodgkin lymphoma1340.23530.36041.41,1300.4
Non-Hodgkin lymphoma360.1850.23440.64,3044.115,61936.220,3886.5
Myeloma320.12,6242.59,16421.211,8213.8
Leukemias3780.63560.86491.14,6274.517,29940.123,3097.4
Mesothelioma1604790.52,1905.12,6860.9

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).
§Counts and rates are suppressed if <16 deaths were reported in a specific category. Some counts and rates are suppressed as complementary cell suppression.

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Return to your place in the textTABLE 7. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site and sex — United States, 2012§
Cancer siteMaleFemaleTotal
No.RateNo.RateNo.Rate
All cancer sites combined 767,366483.0761,712411.71,529,078440.3
Oral cavity and pharynx27,99716.811,8826.339,87911.2
Lip1,3530.94890.31,8420.5
Tongue8,7775.23,5971.912,3743.4
Salivary gland2,4041.61,8501.04,2541.3
Floor of mouth1,3330.86030.31,9360.5
Gum and other mouth2,9151.82,4161.35,3311.5
Nasopharynx1,2630.84950.31,7580.5
Tonsil5,9773.41,3530.77,3302.0
Oropharynx1,3250.84080.21,7330.5
Hypopharynx1,8381.14430.22,2810.6
Other oral cavity and pharynx8120.52280.11,0400.3
Digestive system151,71395.6121,82263.9273,53578.3
Esophagus12,6287.83,3651.715,9934.5
Stomach13,9649.08,6594.622,6236.6
Small intestine4,1872.63,7072.07,8942.3
Colon and rectum70,20444.864,58034.1134,78438.9
Colon excluding rectum47,44830.748,51425.495,96227.8
Rectum and rectosigmoid junction22,75614.116,0668.638,82211.1
Anus, anal canal, and anorectum2,3041.44,0342.16,3381.8
Liver and Intrahepatic bile duct20,20711.87,8054.028,0127.7
Gallbladder1,2210.82,6141.43,8351.1
Other biliary3,2462.12,7171.45,9631.7
Pancreas22,10114.121,11210.943,21312.3
Retroperitoneum6530.46680.41,3210.4
Peritoneum, omentum, and mesentery1570.11,7670.91,9240.5
Other digestive organs8410.57940.41,6350.5
Respiratory system122,78578.5103,14854.0225,93364.7
Nose, nasal cavity, and middle ear1,3760.98980.52,2740.7
Larynx9,5655.82,5871.312,1523.4
Lung and bronchus111,39571.699,43352.1210,82860.4
Pleura6004501050
Trachea, mediastinum, and other respiratory organs3890.31850.15740.2
Bones and joints1,6741.11,2770.82,9510.9
Soft tissue including heart5,8813.84,8472.810,7283.2
Skin excluding basal and squamous42,99227.830,18917.073,18121.5
Melanoma of the skin39,67325.528,08015.967,75319.9
Other nonepithelial skin3,3192.32,1091.15,4281.6
Male and female breast NANANANA226,27265.6
Female breastNANA224,147122.2NANA
Male breast2,1251.4NANANANA
Female genital systemNANA90,30348.8NANA
CervixNANA12,0427.4NANA
Corpus and uterus, NOSNANA49,15425.7NANA
CorpusNANA47,57024.9NANA
Uterus, NOSNANA1,5840.8NANA
OvaryNANA20,78511.3NANA
VaginaNANA1,2960.7NANA
VulvaNANA4,8512.6NANA
Other female genital organsNANA2,1751.2NANA
Male genital system187,308111.8NANANANA
Prostate177,489105.3NANANANA
Testis8,1895.5NANANANA
Penis1,2830.8NANANANA
Other male genital organs3470.2NANANANA
Urinary system89,32258.038,78120.5128,10337.0
Urinary bladder 53,00635.416,9688.769,97420.2
Kidney and renal pelvis34,45921.320,77211.255,23115.9
Ureter1,1950.87230.41,9180.6
Other urinary organs6620.53180.29800.3
Eye and orbit1,4941.01,2390.72,7330.8
Brain and other nervous system11,9517.69,5395.521,4906.5
Brain11,2637.28,8885.120,1516.0
Cranial nerves other nervous system6880.56510.41,3390.4
Endocrine system12,4977.936,09721.948,59415.0
Thyroid11,3137.134,96621.346,27914.3
Other endocrine including thymus1,1840.81,1310.72,3150.7
Lymphomas39,07425.332,61817.871,69221.1
Hodgkin lymphoma4,5693.03,7042.38,2732.6
Non-Hodgkin lymphoma34,50522.328,91415.563,41918.5
Myeloma12,1997.89,6305.021,8296.3
Leukemias25,69916.918,69710.344,39613.2
Acute lymphocytic leukemia2,7321.82,1141.44,8461.6
Chronic lymphocytic leukemia9,0045.85,8173.014,8214.2
Acute myeloid leukemia7,6465.16,1743.413,8204.1
Chronic myeloid leukemia3,1182.12,4251.45,5431.7
Other leukemias3,1992.12,1671.25,3661.6
Mesothelioma2,4071.77920.43,1990.9
Kaposi Sarcoma9510.61250.11,0760.3
Miscellaneous29,29719.626,57913.755,87616.3

Abbreviations: NA = not applicable; NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.

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Return to your place in the textTABLE 8. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site and sex — United States, 2012
Cancer siteMaleFemaleTotal
No.RateNo.RateNo.Rate
All cancer sites combined 305,661200.6276,946141.9582,607166.4
Oral cavity and pharynx6,2633.92,6611.38,9242.5
Lip440270710
Tongue1,4880.97360.42,2240.6
Salivary gland5810.42880.18690.2
Floor of mouth540210750
Gum and other mouth7460.55290.31,2750.4
Nasopharynx4540.32120.16660.2
Tonsil7140.41650.18790.2
Oropharynx6530.42380.18910.2
Hypopharynx2680.28803560.1
Other oral cavity and pharynx1,2610.83570.21,6180.4
Digestive system83,78253.463,24232.0147,02441.6
Esophagus11,6977.32,9521.514,6494.1
Stomach6,6114.34,5802.411,1913.2
Small intestine6890.56040.31,2930.4
Colon and rectum26,86617.624,65012.451,51614.7
Colon excluding rectum21,38314.120,48410.341,86712.0
Rectum and rectosigmoid junction5,4833.54,1662.19,6492.7
Anus, anal canal, and anorectum3680.25210.38890.3
Liver and intrahepatic bile duct15,5639.47,4093.822,9726.3
Gallbladder6870.51,4150.72,1020.6
Other biliary7390.57800.41,5190.4
Pancreas19,71812.719,0799.638,79711.0
Retroperitoneum1100.1970.12070.1
Peritoneum, omentum, and mesentery7806720.37500.2
Other digestive organs6560.44830.21,1390.3
Respiratory system90,09158.471,76037.0161,85146.2
Nose, nasal cavity, and middle ear2850.21730.14580.1
Larynx2,9251.87370.43,6621.0
Lung and bronchus86,68956.270,73436.4157,42345.0
Pleura510310820
Trachea, mediastinum, and other respiratory organs1410.18502260.1
Bones and joints8180.55810.31,3990.4
Soft tissue including heart2,3941.62,1651.24,5591.3
Skin excluding basal and squamous8,3295.54,1342.112,4633.6
Melanoma of the skin6,0134.03,2381.79,2512.7
Other nonepithelial skin2,3161.68960.43,2120.9
Male and female breast NANANANA41,55511.8
Female breastNANA41,15021.3NANA
Male breast4050.3NANANANA
Female genital systemNANA29,40515.2NANA
CervixNANA4,0742.3NANA
Corpus and uterus, NOSNANA8,9114.5NANA
CorpusNANA3,8121.9NANA
Uterus, NOSNANA5,0992.6NANA
OvaryNANA14,4047.4NANA
VaginaNANA4290.2NANA
VulvaNANA1,0340.5NANA
Other female genital organsNANA5530.3NANA
Male genital system27,95520.0NANANANA
Prostate27,24419.6NANANANA
Testis3860.3NANANANA
Penis2730.2NANANANA
Other male genital organs520NANANANA
Urinary system20,13613.69,4584.729,5948.5
Urinary bladder 10,8867.64,3592.115,2454.4
Kidney and renal pelvis8,7725.64,7462.413,5183.8
Ureter2120.11660.13780.1
Other urinary organs2660.21870.14530.1
Eye and orbit1640.11150.12790.1
Brain and other nervous system8,6665.46,6103.515,2764.4
Endocrine system1,2640.81,3960.72,6600.8
Thyroid7750.59150.51,6900.5
Other endocrine including thymus4890.34810.39700.3
Lymphomas11,9028.09,6164.921,5186.2
Hodgkin lymphoma6380.44920.31,1300.3
Non-Hodgkin lymphoma11,2647.69,1244.620,3885.9
Myeloma6,3384.25,4832.811,8213.4
Leukemias13,4669.29,8435.123,3096.8
Acute lymphocytic leukemia8100.55980.31,4080.4
Chronic lymphocytic leukemia2,8372.01,7610.94,5981.3
Acute myeloid leukemia5,4013.64,0832.29,4842.8
Chronic myeloid leukemia5460.44710.21,0170.3
Other leukemias3,8722.72,9301.56,8022.0
Mesothelioma2,1121.55740.32,6860.8
Miscellaneous21,53814.118,7389.440,27611.5

Abbreviations: NA = not applicable; NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).

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Return to your place in the textTABLE 9. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site and race§ —United States, 2012
Cancer siteAI/AN§API§BlackWhiteTotal
No.RateNo.RateNo.RateNo.RateNo.Rate
All cancer sites combined 8,139269.045,364285.7165,559446.11,282,703440.41,529,078440.3
Oral cavity and pharynx2276.81,2677.73,5749.134,26311.539,87911.2
Lip—**420.11,7180.61,8420.5
Tongue511.52881.87862.011,0823.712,3743.4
Salivary gland180.51801.13931.03,5971.34,2541.3
Floor of mouth260.22060.51,6660.51,9360.5
Gum and other mouth240.82071.35111.44,5001.55,3311.5
Nasopharynx210.63842.22630.71,0640.41,7580.5
Tonsil451.2810.56251.56,5122.27,3302.0
Oropharynx200.12410.61,4490.51,7330.5
Hypopharynx210.7540.33901.01,7960.62,2810.6
Other oral cavity and pharynx160.51170.38790.31,0400.3
Digestive system1,72258.411,01672.134,40494.8223,15475.7273,53578.3
Esophagus732.63032.01,5144.113,9634.715,9934.5
Stomach1676.11,57110.53,53210.217,0565.822,6236.6
Small intestine250.81811.11,3013.56,3002.27,8942.3
Colon and rectum83528.54,77230.816,40245.5111,04138.0134,78438.9
Colon excluding rectum54719.73,07320.312,25634.679,01227.195,96227.8
Rectum and rectosigmoid junction2888.81,69910.54,14610.932,02911.038,82211.1
Anus, anal canal, and anorectum330.9810.57031.85,4501.86,3381.8
Liver and Intrahepatic bile duct2808.52,00812.74,09710.021,2237.028,0127.7
Gallbladder481.92041.45581.62,9791.03,8351.1
Other biliary280.93632.55061.55,0231.75,9631.7
Pancreas1977.01,3409.35,29315.136,00112.143,21312.3
Retroperitoneum430.31640.41,0880.41,3210.4
Peritoneum, omentum, and mesentery700.41350.41,6980.61,9240.5
Other digestive organs800.51990.61,3320.51,6350.5
Respiratory system1,16742.35,36936.824,48468.6193,41765.2225,93364.7
Nose, nasal cavity, and middle ear940.62320.61,9080.72,2740.7
Larynx561.81591.01,7064.410,1233.312,1523.4
Lung and bronchus1,09640.15,08835.022,47563.3180,82361.0210,82860.4
Pleura9101050
Trachea, mediastinum, and other respiratory organs260.2610.24720.25740.2
Bones and joints190.41090.63080.72,4581.02,9510.9
Soft tissue including heart722.13562.11,3083.48,8093.210,7283.2
Skin excluding basal and squamous1675.63152.06641.868,55224.273,18121.5
Melanoma of the skin1414.71971.23320.963,87522.667,75319.9
Other nonepithelial skin260.81180.83320.94,6771.65,4281.6
Male and female breast 1,14536.18,41649.325,92768.5188,47465.5226,27265.6
Female breast1,14367.88,35789.725,630120.1186,726123.3224,147122.2
Male breast590.82972.01,7481.32,1251.4
Female genital system59833.93,27934.910,01546.975,24149.490,30348.8
Cervix1196.35766.11,9079.09,1747.112,0427.4
Corpus and uterus, NOS29015.91,70417.95,33424.741,23526.149,15425.7
Corpus28115.31,64817.34,99523.140,08225.347,57024.9
Uterus, NOS560.63391.61,1530.71,5840.8
Ovary1388.48108.71,9599.317,67111.620,78511.3
Vagina370.41991.01,0310.71,2960.7
Vulva241.5660.84132.04,2852.74,8512.6
Other female genital organs161.0861.02031.01,8451.22,1751.2
Male genital system83260.13,97557.128,484172.2146,244103.0187,308111.8
Prostate75056.43,75554.528,003169.4137,48895.6177,489105.3
Testis763.21641.83051.57,4106.38,1895.5
Penis370.61421.01,0700.81,2830.8
Other male genital organs190.3340.22760.23470.2
Urinary system71023.92,44316.410,39928.8112,78138.4128,10337.0
Urinary bladder 2228.61,2088.63,77811.363,56421.569,97420.2
Kidney and renal pelvis48015.01,1657.36,42016.946,62516.055,23115.9
Ureter530.4800.21,7690.61,9180.6
Other urinary organs170.11210.38230.39800.3
Eye and orbit360.2930.22,5130.92,7330.8
Brain and other nervous system1143.26223.61,6154.118,8586.921,4906.5
Brain1073.15763.41,4653.717,7656.520,1516.0
Cranial nerves other nervous system460.31500.41,0930.41,3390.4
Endocrine system2857.42,82215.63,8939.940,66215.648,59415.0
Thyroid2757.22,67714.83,5298.938,88814.946,27914.3
Other endocrine including thymus1450.83640.91,7740.72,3150.7
Lymphomas34011.62,15413.76,18516.161,67121.771,69221.1
Hodgkin lymphoma320.92121.11,0962.66,7872.78,2732.6
Non-Hodgkin lymphoma30810.81,94212.55,08913.554,88419.063,41918.5
Myeloma1164.14913.24,39212.416,4805.621,8296.3
Leukemias2527.91,2007.53,83810.537,96813.544,39613.2
Acute lymphocytic leukemia511.22421.44401.04,0111.74,8461.6
Chronic lymphocytic leukemia511.91721.11,0663.112,9214.314,8214.2
Acute myeloid leukemia862.84953.21,2943.611,8084.213,8204.1
Chronic myeloid leukemia361.21771.15641.54,6311.75,5431.7
Other leukemias280.81140.74741.34,5971.65,3661.6
Mesothelioma350.31620.52,9631.03,1990.9
Kaposi Sarcoma270.13200.86480.31,0760.3
Miscellaneous34212.91,43210.05,49416.047,54716.255,87616.3

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander; NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Rates are not presented for persons of unknown or other race, therefore categories do not sum to total. Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
**Counts and rates are suppressed if <16 cases were reported.

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Return to your place in the textTABLE 10. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site and race — United States, 2012§
Cancer siteAI/ANƗAPIƗBlackWhiteTotal
No.RateNo.RateNo.RateNo.RateNo.Rate
All cancer sites combined 3,018112.515,339104.267,374194.4496,876166.4582,607166.4
Oral cavity and pharynx481.63202.01,0742.97,4822.58,9242.5
Lip680710
Tongue580.42000.51,9560.62,2240.6
Salivary gland190.1670.27810.38690.2
Floor of mouth710750
Gum and other mouth410.31180.31,1080.41,2750.4
Nasopharynx1410.81000.34190.16660.2
Tonsil1080.37530.28790.2
Oropharynx170.11460.47230.28910.2
Hypopharynx500.12970.13560.1
Other oral cavity and pharynx210.12810.81,3060.41,6180.4
Digestive system90833.15,51137.518,93053.9121,67540.5147,02441.6
Esophagus672.52411.61,3873.712,9544.314,6494.1
Stomach1003.98325.72,0015.98,2582.811,1913.2
Small intestine320.21990.51,0600.41,2930.4
Colon and rectum30111.21,57810.86,86119.942,77614.351,51614.7
Colon excluding rectum2469.21,2708.85,72716.834,62411.641,86712.0
Rectum and rectosigmoid junction552.03082.01,1343.28,1522.79,6492.7
Anus, anal canal, and anorectum990.37780.38890.3
Liver and intrahepatic bile duct2077.01,4999.93,1908.318,0765.922,9726.3
Gallbladder241.1860.62850.81,7070.62,1020.6
Other biliary610.41210.41,3270.41,5190.4
Pancreas1806.51,1137.94,59513.432,90910.938,79711.0
Retroperitoneum1601840.12070.1
Peritoneum, omentum, and mesentery180.1500.16790.27500.2
Other digestive organs370.31260.49670.31,1390.3
Respiratory system81831.13,52824.617,48450.3140,02146.9161,85146.2
Nose, nasal cavity, and middle ear190.1400.13970.14580.1
Larynx180.6560.46281.72,9601.03,6621.0
Lung and bronchus79630.43,44124.016,78048.4136,40645.7157,42345.0
Pleura750820
Trachea, mediastinum, and other respiratory organs310.11830.12260.1
Bones and joints420.31650.41,1860.41,3990.4
Soft tissue including heart351.11470.95671.53,8101.34,5591.3
Skin excluding basal and squamous321.3900.62730.812,0684.112,4633.6
Melanoma of the skin190.8580.41380.49,0363.19,2512.7
Other nonepithelial skin320.21350.43,0321.03,2120.9
Male and female breast 1735.91,0366.36,24617.234,10011.441,55511.8
Female breast17210.81,03211.36,18629.433,76020.741,15021.3
Male breast600.43400.34050.3
Female genital system17111.18589.63,98419.424,39215.029,40515.2
Cervix412.31541.77803.73,0992.14,0742.3
Corpus and uterus, NOS473.12803.21,6668.26,9184.18,9114.5
Corpus211.21311.56463.23,0141.83,8121.9
Uterus, NOS261.81491.71,0205.03,9042.35,0992.6
Ovary745.03854.31,3596.612,5867.714,4047.4
Vagina560.33600.24290.2
Vulva640.39520.61,0340.5
Other female genital organs160.2590.34770.35530.3
Male genital system13414.44418.64,65542.122,72518.627,95520.0
Prostate12714.04298.44,59541.822,09318.127,24419.6
Testis260.13470.33860.3
Penis270.22410.22730.2
Other male genital organs440520
Urinary system1485.55073.72,4117.226,5288.829,5948.5
Urinary bladder 331.32321.81,0903.513,8904.615,2454.4
Kidney and renal pelvis1073.92561.71,2673.611,8884.013,5183.8
Ureter3510.13780.1
Other urinary organs410.13990.14530.1
Eye and orbit2600.12790.1
Brain and other nervous system632.03362.11,0092.713,8684.815,2764.4
Endocrine system1340.93110.92,2080.82,6600.8
Thyroid900.61650.51,4300.51,6900.5
Other endocrine including thymus440.31460.47780.39700.3
Lymphomas753.25874.11,5954.619,2616.521,5186.2
Hodgkin lymphoma200.11330.39740.31,1300.3
Non-Hodgkin lymphoma723.25674.01,4624.318,2876.220,3885.9
Myeloma482.02411.72,0856.39,4473.211,8213.4
Leukemias963.45994.11,9655.820,6497.123,3096.8
Acute lymphocytic leukemia530.31210.31,2220.51,4080.4
Chronic lymphocytic leukemia380.33651.24,1831.44,5981.3
Acute myeloid leukemia441.53232.27682.28,3492.99,4842.8
Chronic myeloid leukemia210.11080.38850.31,0170.3
Other leukemias251.01641.26031.86,0102.06,8022.0
Mesothelioma280.21250.42,5190.92,6860.8
Miscellaneous2368.99306.54,47112.934,63911.540,27611.5

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander; NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
§Data are from the National Vital Statistics System (NVSS).
Counts and rates are suppressed if <16 deaths were reported.

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Return to your place in the textTABLE 11. Reported number and age-adjusted rate* of invasive cancer cases, by primary cancer site and ethnicity§ — United States, 2012
Cancer siteHispanicNon-HispanicTotal
No.RateNo.RateNo.Rate
All cancer sites combined 111,815340.51,417,061451.41,529,078440.3
Oral cavity and pharynx2,3186.937,56111.739,87911.2
Lip870.31,7550.61,8420.5
Tongue6291.911,7453.612,3743.4
Salivary gland3240.93,9301.34,2541.3
Floor of mouth900.31,8460.61,9360.5
Gum and other mouth3661.24,9651.65,3311.5
Nasopharynx1480.41,6100.51,7580.5
Tonsil3641.06,9662.17,3302.0
Oropharynx970.31,6360.51,7330.5
Hypopharynx1390.42,1420.62,2810.6
Other oral cavity and pharynx740.29660.31,0400.3
Digestive system24,11778.3249,37078.5273,53578.3
Esophagus8472.815,1434.715,9934.5
Stomach2,9269.519,6946.222,6236.6
Small intestine5611.77,3332.37,8942.3
Colon and rectum10,58534.0124,18639.5134,78438.9
Colon excluding rectum7,15823.888,79128.395,96227.8
Rectum and rectosigmoid junction3,42710.235,39511.238,82211.1
Anus, anal canal, and anorectum4491.45,8881.96,3381.8
Liver and Intrahepatic bile duct4,06612.723,9377.228,0127.7
Gallbladder5391.93,2951.03,8351.1
Other biliary6502.25,3131.75,9631.7
Pancreas3,07910.740,11612.543,21312.3
Retroperitoneum1280.31,1930.41,3210.4
Peritoneum, omentum, and mesentery1340.41,7900.61,9240.5
Other digestive organs1530.51,4820.51,6350.5
Respiratory system9,65534.4216,23167.5225,93364.7
Nose, nasal cavity, and middle ear1910.62,0830.72,2740.7
Larynx7362.411,4133.512,1523.4
Lung and bronchus8,64831.2202,13663.2210,82860.4
Pleura—**10100
Trachea, mediastinum, and other respiratory organs760.14980.25740.2
Bones and joints4150.92,5360.92,9510.9
Soft tissue including heart1,0922.89,6363.310,7283.2
Skin excluding basal and squamous1,7265.171,45223.673,18121.5
Melanoma of the skin1,4234.266,32821.967,75319.9
Other nonepithelial skin3030.95,1241.75,4281.6
Male and female breast 17,12949.0209,13567.6226,27265.6
Female breast17,01491.3207,125125.9224,147122.2
Male breast1150.82,0101.42,1251.4
Female genital system8,55744.581,73649.190,30348.8
Cervix1,9989.510,0447.112,0427.4
Corpus and uterus, NOS4,13521.845,01526.049,15425.7
Corpus3,97620.943,59325.247,57024.9
Uterus, NOS1590.91,4220.81,5840.8
Ovary1,88510.018,89411.420,78511.3
Vagina1080.61,1880.71,2960.7
Vulva2681.74,5832.74,8512.6
Other female genital organs1630.92,0121.22,1751.2
Male genital system13,65395.7173,628113.7187,308111.8
Prostate12,12189.8165,342107.0177,489105.3
Testis1,3114.46,8775.78,1895.5
Penis2041.41,0790.81,2830.8
Other male genital organs170.13300.23470.2
Urinary system8,51827.4119,57137.9128,10337.0
Urinary bladder 3,04111.166,92521.169,97420.2
Kidney and renal pelvis5,35015.949,87515.955,23115.9
Ureter800.31,8380.61,9180.6
Other urinary organs470.29330.39800.3
Eye and orbit2060.52,5270.92,7330.8
Brain and other nervous system1,9904.919,4976.721,4906.5
Brain1,8464.618,3026.320,1516.0
Cranial nerves other nervous system1440.31,1950.51,3390.4
Endocrine system5,80613.742,78315.448,59415.0
Thyroid5,55513.140,72214.646,27914.3
Other endocrine including thymus2510.62,0610.72,3150.7
Lymphomas6,46218.965,22221.571,69221.1
Hodgkin lymphoma1,0292.37,2442.78,2732.6
Non-Hodgkin lymphoma5,43316.657,97818.763,41918.5
Myeloma1,8696.219,9556.321,8296.3
Leukemias3,98810.340,40313.444,39613.2
Acute lymphocytic leukemia1,2642.23,5821.54,8461.6
Chronic lymphocytic leukemia5421.914,2784.514,8214.2
Acute myeloid leukemia1,2723.612,5464.113,8204.1
Chronic myeloid leukemia4901.45,0511.75,5431.7
Other leukemias4201.24,9461.65,3661.6
Mesothelioma2000.72,9971.03,1990.9
Kaposi Sarcoma1980.58780.31,0760.3
Miscellaneous3,91613.651,94316.555,87616.3

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Rates and counts are not presented for persons of unknown ethnicity, therefore categories do not sum to total. Data for specified ethnic populations should be interpreted with caution. For more information, see USCS technical notes http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria.
**Counts and rates are suppressed if <16 cases were reported. Some counts and rates are suppressed as complementary cell suppression.

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Return to your place in the textTABLE 12. Reported number and age-adjusted rate* of cancer deaths, by primary cancer site and ethnicity — United States, 2012§
Cancer siteHispanic§Non-HispanicTotal
No.RateNo.RateNo.Rate
All cancer sites combined 34,146117.8547,027170.4582,607166.4
Oral cavity and pharynx4761.68,4212.68,9242.5
Lip650710
Tongue1180.42,0990.62,2240.6
Salivary gland480.28190.38690.2
Floor of mouth680750
Gum and other mouth660.21,2060.41,2750.4
Nasopharynx370.16270.26660.2
Tonsil390.18350.38790.2
Oropharynx430.18480.38910.2
Hypopharynx250.13290.13560.1
Other oral cavity and pharynx870.31,5250.51,6180.4
Digestive system11,38239.3135,28741.8147,02441.6
Esophagus6212.113,9954.314,6494.1
Stomach1,5905.29,5703.011,1913.2
Small intestine680.21,2210.41,2930.4
Colon and rectum3,34911.848,03415.051,51614.7
Colon excluding rectum2,7379.739,01712.241,86712.0
Rectum and rectosigmoid junction6122.09,0172.89,6492.7
Anus, anal canal, and anorectum400.18450.38890.3
Liver and intrahepatic bile duct2,7809.320,1356.122,9726.3
Gallbladder2621.01,8330.62,1020.6
Other biliary1360.51,3830.41,5190.4
Pancreas2,4078.636,30711.238,79711.0
Retroperitoneum1601900.12070.1
Peritoneum, omentum, and mesentery460.17030.27500.2
Other digestive organs670.21,0710.31,1390.3
Respiratory system5,50320.4155,92548.4161,85146.2
Nose, nasal cavity, and middle ear370.14200.14580.1
Larynx2140.83,4331.03,6621.0
Lung and bronchus5,22519.4151,79347.1157,42345.0
Pleura770820
Trachea, mediastinum, and other respiratory organs220.12020.12260.1
Bones and joints1360.31,2620.41,3990.4
Soft tissue including heart3901.14,1551.44,5591.3
Skin excluding basal and squamous3501.212,0853.812,4633.6
Melanoma of the skin2240.79,0102.99,2512.7
Other nonepithelial skin1260.53,0750.93,2120.9
Male and female breast 2,6278.138,82612.141,55511.8
Female breast2,61314.738,43621.941,15021.3
Male breast3900.34050.3
Female genital system2,21212.827,11315.429,40515.2
Cervix5202.73,5362.24,0742.3
Corpus and uterus, NOS6193.78,2694.68,9114.5
Corpus2451.53,5552.03,8121.9
Uterus, NOS3742.24,7142.65,0992.6
Ovary9635.813,4077.514,4047.4
Vagina320.23960.24290.2
Vulva450.39860.51,0340.5
Other female genital organs330.25190.35530.3
Male genital system1,70617.126,18920.227,95520.0
Prostate1,59216.525,59519.827,24419.6
Testis750.23090.23860.3
Penis360.32370.22730.2
Other male genital organs480520
Urinary system1,6606.027,8758.629,5948.5
Urinary bladder 5842.314,6304.515,2454.4
Kidney and renal pelvis1,0423.612,4513.813,5183.8
Ureter3620.13780.1
Other urinary organs190.14320.14530.1
Eye and orbit180.12600.12790.1
Brain and other nervous system1,0493.014,1944.615,2764.4
Endocrine system2480.82,4090.82,6600.8
Thyroid1680.61,5210.51,6900.5
Other endocrine including thymus800.28880.39700.3
Lymphomas1,5515.419,9146.321,5186.2
Hodgkin lymphoma1230.41,0050.31,1300.3
Non-Hodgkin lymphoma1,4285.018,9096.020,3885.9
Myeloma7822.911,0193.411,8213.4
Leukemias1,6035.021,6616.923,3096.8
Acute lymphocytic leukemia3250.71,0800.41,4080.4
Chronic lymphocytic leukemia1250.54,4631.44,5981.3
Acute myeloid leukemia5821.98,8852.99,4842.8
Chronic myeloid leukemia760.39360.31,0170.3
Other leukemias4951.76,2972.06,8022.0
Mesothelioma1320.52,5450.82,6860.8
Miscellaneous2,3138.237,84211.740,27611.5

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS).
§Data for specified ethnic populations should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).
Counts and rates are suppressed if <16 deaths were reported.

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Return to your place in the textFIGURE 1. Age-adjusted rate* of invasive cancer cases for most common sites, by sex and race/ethnicity§ — United States, 2012
	The figure presents 10 bar charts showing the age-adjusted rate per 100,000 population for 2012 for three types of invasive cancer — breast, lung and bronchus, and rectum — by sex and race/ethnicity. Data are drawn from CDC’s National Program of Cancer Registries and the National Cancer Institute’s Surveillance, Epidemiology, and End Results program.

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander.

Sources: CDC’s National Program of Cancer Registries and National Cancer Institute’s Surveillance, Epidemiology, and End Results program.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Race categories are not mutually exclusive from Hispanic origin. Rates are not presented for persons of unknown or other race. Data for specified racial or ethnic populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria. Caution should be used when comparing incidence and death rates because of the difference in population coverage.

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Return to your place in the textFIGURE 2. Age-adjusted rate* of invasive cancer cases, by primary cancer site and state — United States, 2012§
	This figure presents six maps of the United States showing the age-adjusted rate per 100,000 persons of invasive cancer cases for 2012 by primary cancer site for all cancer sites combined, female breast, lung, prostate, cervix uteri, and colon and rectum. The number of cases varies by state.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined (covering approximately 99% of the U.S. population). Registry-specific data quality information is available at http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Return to your place in the textFIGURE 3. Age-adjusted rate* of cancer deaths, by primary cancer site and state — United States, 2012
	This figure presents six maps of the United States showing the age-adjusted rate per 100,000 persons of cancer deaths for 2012 by primary cancer site for all cancer sites combined, female breast, lung, prostate, cervix uteri, and colon and rectum. The number of cases varies by state.

* Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS Technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Data are from the National Vital Statistics System (NVSS). Data for death rates cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Return to your place in the textTABLE 13. Reported number of invasive* cancer cases by primary cancer site and year — United States, 1999–2012
Cancer site19992000200120022003200420052006200720082009201020112012
All cancer sites combined 1,227,5621,249,5591,273,0171,285,6181,279,5101,296,8771,318,8141,349,5901,387,1161,402,5671,414,1111,403,5651,424,7341,399,978
Oral cavity and pharynx27,49127,95428,23628,90429,50629,98030,31531,31432,79834,21434,61935,39536,79036,990
Lip2,4442,3932,3092,3332,0411,9611,8591,8801,8831,8671,8321,9521,8861,725
Tongue6,6406,8597,0177,4787,7378,0918,2988,7259,39910,10010,22410,28211,11811,476
Salivary gland2,9823,1473,1803,2203,3053,3573,4703,5993,6283,7543,7743,7623,7923,986
Floor of mouth2,0742,0532,0752,0181,9401,9161,8271,9441,9231,9341,9201,9241,8381,787
Gum and other mouth4,3574,1974,3124,2364,3874,3484,3384,3724,5644,7594,6634,8464,9274,915
Nasopharynx1,4711,5271,4161,5351,6221,5591,6181,5651,7221,7131,6011,6601,6351,640
Tonsil3,4093,5843,7804,0324,3164,5704,7565,0685,3075,7306,2636,3486,7546,786
Oropharynx9951,0601,1061,1101,2771,2951,2981,4041,4161,4791,4601,6661,7041,598
Hypopharynx2,1872,1532,0852,0662,1632,1312,1202,0342,1312,0822,1272,0742,1242,106
Other oral cavity and pharynx9329819568767187527317238257967558811,012971
Digestive system232,437235,790238,113239,050242,294243,671244,545246,111249,358252,542252,284250,837254,183254,508
Esophagus12,69112,88613,08213,10513,60614,15214,05814,52214,53515,09215,22014,59814,99814,884
Stomach19,35019,22719,18419,41819,68919,65319,39219,40019,82719,67420,03620,92521,05421,168
Small intestine4,3124,3144,6144,8825,0385,3795,5935,9746,1796,5026,7067,1247,1887,336
Colon and rectum142,816144,059143,905142,685142,037140,094138,690136,944136,405135,443131,492127,515127,219124,944
Colon excluding rectum104,182105,255105,235104,439103,760102,098100,50399,46498,77298,05594,44491,34491,13488,810
Rectum and rectosigmoid junction38,63438,80438,67038,24638,27737,99638,18737,48037,63337,38837,04836,17136,08536,134
Anus, anal canal, and anorectum3,4673,5413,6263,8014,1984,3144,5064,5034,9675,2305,6145,4425,6945,876
Liver and Intrahepatic bile duct12,47013,41513,50214,45115,22116,46017,38118,42620,09721,26423,13023,86225,02826,279
Gallbladder3,1022,9923,1492,9803,1223,1403,2313,2793,3143,3303,5503,5383,6073,614
Other biliary3,3563,5444,2214,4014,5654,6244,6774,8624,8745,1415,3495,4375,6355,603
Pancreas28,02428,80129,42129,80431,08531,92232,98534,13734,96136,51936,95038,11239,24240,229
Retroperitoneum9909631,0331,0621,0381,0571,1251,0941,1141,1361,1351,1511,2271,257
Peritoneum, omentum, and mesentery1,1011,1881,3911,4721,6461,8181,8131,7511,8951,9811,8381,8081,8351,791
Other digestive organs7588609859891,0491,0581,0941,2191,1901,2301,2641,3251,4561,527
Respiratory system193,612194,368196,473198,631201,452202,402206,455207,257208,946211,173211,521208,570207,967207,627
Nose, nasal cavity, and middle ear1,8051,7991,7651,8701,8151,9281,9661,9532,1162,0802,1042,0052,0452,126
Larynx11,69611,51311,40911,08111,20211,42711,37311,45711,50711,48911,49911,62711,40011,106
Lung and bronchus179,444180,405182,729185,079187,813188,372192,465193,219194,673196,903197,245194,261193,906193,768
Pleura1041017797929893831029910410392100
Trachea, mediastinum, and other respiratory organs563550493504530577558545548602569574524527
Bones and joints2,4722,4622,6272,6452,5772,6402,7522,6922,7552,6872,8082,7082,7662,769
Soft tissue including heart7,3337,6877,8468,0358,3838,7929,0258,8979,4499,5899,7079,9789,81010,000
Skin excluding basal and squamous42,23145,62449,07850,75651,02654,24658,46658,59160,95963,46765,47765,30667,70468,633
Melanoma of the skin38,86741,92545,14146,75746,93550,04054,09654,22556,30358,48460,33560,39762,67463,502
Other nonepithelial skin3,3643,6993,9373,9994,0914,2064,3704,3664,6564,9835,1424,9095,0305,131
Male and female breast 187,922187,408189,541188,438181,949182,828185,308189,451194,935200,299205,221201,894208,322210,356
Female breast186,459185,946188,139186,934180,386181,216183,738187,819193,211198,411203,405199,991206,446208,404
Male breast1,4631,4621,4021,5041,5631,6121,5701,6321,7241,8881,8161,9031,8761,952
Female genital system71,59172,19372,98672,69871,89372,88174,55675,67577,44679,35481,18581,43783,02084,199
Cervix12,99112,98412,39912,07911,72611,49111,71911,65311,70511,62311,80711,39511,33911,145
Corpus and uterus, NOS33,45833,50134,73134,92734,38835,86836,92837,85939,26040,75542,49643,34744,70945,902
Corpus32,35032,36633,57333,76333,22434,72735,75136,72138,12439,44041,08141,97043,24744,449
Uterus, NOS1,1081,1351,1581,1641,1641,1411,1771,1381,1361,3151,4151,3771,4621,453
Ovary19,87520,33920,36120,07520,18719,80520,11320,17520,13120,40920,00019,56919,52419,382
Vagina1,0201,0881,0751,1001,0521,1031,0101,0831,0971,1461,1541,1631,1781,199
Vulva3,4013,3483,4943,5153,5513,5793,7003,7883,9864,0174,2014,2234,3554,502
Other female genital organs8469339261,0029891,0351,0861,1171,2671,4041,5271,7401,9152,069
Male genital system194,920200,489206,681208,978196,114195,842196,522214,202226,520215,968211,749203,731207,234173,864
Prostate186,717192,151198,257200,678187,529187,229187,731205,526217,631206,730202,691194,600198,110164,613
Testis6,9377,0527,1607,0177,2517,3557,5017,3467,5097,6907,6507,6737,5797,724
Penis1,0041,0089911,0251,0539889971,0251,0991,2111,1061,1431,2061,194
Other male genital organs262278273258281270293305281337302315339333
Urinary system89,16691,90294,17897,018100,211103,654106,689108,167111,587114,459115,944115,668117,650119,465
Urinary bladder 55,82256,84557,15358,16859,24260,73261,70660,72162,48463,35464,13864,05164,87265,494
Kidney and renal pelvis31,07332,82434,75636,62938,70640,61542,66144,96546,60848,38349,20349,01850,06851,269
Ureter1,5531,5361,5601,5651,5731,6081,6001,7211,6681,7011,7231,7201,7641,783
Other urinary organs7186977096566906997227608271,021880879946919
Eye and orbit2,1852,2662,2832,2582,4412,4592,4402,4842,5382,5142,5372,4382,4742,589
Brain and other nervous system17,61117,83017,76618,26718,35318,87918,99319,20119,51219,85820,01919,80919,89319,929
Brain16,44616,58116,54117,06917,00017,54217,66117,97518,20418,54318,70918,58718,70318,727
Cranial nerves other nervous system1,1651,2491,2251,1981,3531,3371,3321,2261,3081,3151,3101,2221,1901,202
Endocrine system19,09321,07422,59424,40125,85628,35331,03033,17436,00039,38641,69342,58443,92445,696
Thyroid17,38519,32220,73122,55723,90526,26328,94631,07133,81637,08939,50640,32241,81443,523
Other endocrine including thymus1,7081,7521,8631,8441,9512,0902,0842,1032,1842,2972,1872,2622,1102,173
Lymphomas56,38157,05458,14759,57860,94862,81363,61363,76265,11666,35067,26267,80067,17367,005
Hodgkin lymphoma7,2727,4617,3467,6787,6177,7267,9817,9057,9728,2738,0128,0697,8847,704
Non-Hodgkin lymphoma49,10949,59350,80151,90053,33155,08755,63255,85757,14458,07759,25059,73159,28959,301
Myeloma14,18414,84915,30815,60815,90116,54816,87916,94617,23618,12218,82819,41619,94220,284
Leukemias32,68834,53335,36734,80835,97036,58036,75237,61437,87538,50839,19241,21441,53041,569
Acute lymphocytic leukemia3,6703,8233,9393,9163,9704,1314,0664,2694,3804,5364,4914,6004,7014,536
Chronic lymphocytic leukemia10,49911,45512,04912,14912,66913,13313,51113,68313,35213,54813,60513,75913,89713,938
Acute myeloid leukemia9,53510,08910,1929,89510,14310,13210,01510,29210,40710,82410,93812,20812,44812,883
Chronic myeloid leukemia4,1224,3054,3434,1044,3024,4374,3704,6124,6434,7585,0455,2785,3055,223
Other leukemias4,8624,8614,8444,7444,8864,7474,7904,7585,0934,8425,1135,3695,1794,989
Mesothelioma2,8252,8892,8912,9352,9252,9643,0742,9782,9743,0123,0483,0703,0793,002
Kaposi Sarcoma1,4061,3991,3911,3061,3491,3151,3551,2261,2631,1911,1721,1121,1131,036
Miscellaneous32,01431,78831,51131,30430,36230,03030,04529,84829,84929,87429,84530,59830,16030,457

Abbreviation: NOS = not otherwise specified.
*Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing number of cases and deaths because of potential differences in population coverage.

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Return to your place in the textTABLE 14. Reported number of cancer deaths, by primary cancer site and year — United States, 1999–2012*
Cancer site19992000200120022003200420052006200720082009201020112012
All cancer sites combined 549,829553,080553,760557,264556,890553,880559,303559,880562,867565,460567,614574,738576,685582,607
Oral cavity and pharynx7,4867,4927,7017,7377,7777,8267,7737,7208,0678,0197,9228,4748,6578,924
Lip5267777472746051666857698371
Tongue1,7381,7671,8181,8871,8751,8811,9481,9062,0341,9831,9712,1252,0892,224
Salivary gland656663685722696697701699742718795827820869
Floor of mouth18015313514914712213511410299109938475
Gum and other mouth1,2151,2131,1791,1521,1761,1681,1181,1081,1091,1601,0911,2121,2451,275
Nasopharynx638650621628598637615633677645662701630666
Tonsil543518612638608592647654688724736795842879
Oropharynx600547592606626658655650721734720806861891
Hypopharynx385359348323318368281301324294279324322356
Other oral cavity and pharynx1,4791,5551,6341,5581,6611,6291,6131,6041,6041,5941,5021,5221,6811,618
Digestive system130,070131,455131,726132,541133,010132,215133,562135,140136,419138,469139,200142,680144,007147,024
Esophagus11,91712,23212,52912,70012,86013,02313,49913,68513,59213,71413,90814,49014,44614,649
Stomach12,71112,64512,31912,19812,11011,85911,51411,34511,38811,35211,18411,39011,03511,191
Small intestine1,0361,0571,0821,0171,0701,1151,1171,0911,0831,1921,1951,2181,2561,293
Colon and rectum57,22257,43456,80856,60355,78353,58053,00553,19653,21952,85751,84852,04551,78351,516
Colon excluding rectum48,96249,01948,29247,98747,24844,98844,32544,33144,24743,65042,47142,24542,18141,867
Rectum and rectosigmoid junction8,2608,4158,5168,6168,5358,5928,6808,8658,9729,2079,3779,8009,6029,649
Anus, anal canal, and anorectum462492511539555589583623644718818813863889
Liver and intrahepatic bile duct12,38212,91613,35114,04714,70615,32116,07516,52517,14618,21319,35220,30421,60822,972
Gallbladder2,0591,9491,9711,9071,9151,9361,9892,0001,9141,9712,0482,1052,1012,102
Other biliary1,5311,7171,6301,5011,4911,4611,4641,4271,4361,3771,3841,5191,5101,519
Pancreas29,08129,33129,80230,26330,77731,77132,75933,45434,11735,23435,62836,88837,34438,797
Retroperitoneum220262220219191219238190204226186202219207
Peritoneum, omentum, and mesentery429503543616602686648698721695703702807750
Other digestive organs1,0209179609319506556719069559209461,0041,0351,139
Respiratory system156,708160,051160,602162,148162,589162,400163,751163,134163,065163,141162,492162,730161,376161,851
Nose, nasal cavity, and middle ear456419485444457458484426475516530495416458
Larynx3,8153,8613,7973,7223,7913,6683,7963,8213,6343,7603,6303,6913,7323,662
Lung and bronchus152,061155,426155,969157,630157,990158,006159,217158,599158,683158,592158,081158,248156,953157,423
Pleura9976847376786764485455546182
Trachea, mediastinum, and other respiratory organs277269267279275190187224225219196242214226
Bones and joints1,2241,2121,2981,1941,2621,3011,3911,3401,3621,3571,3841,3781,4231,399
Soft tissue including heart3,6793,6933,6463,5543,6513,7223,8493,9604,0234,0934,2294,3764,4084,559
Skin excluding basal and squamous9,5309,6729,9929,90410,21410,30110,79811,06811,23411,33712,13012,08912,21212,463
Melanoma of the skin7,2157,4207,5427,5137,8187,9528,3458,4418,4618,6239,1999,1549,1289,251
Other nonepithelial skin2,3152,2522,4502,3912,3962,3492,4532,6272,7732,7142,9312,9353,0843,212
Male and female breast 41,52842,30041,80941,88341,99841,31641,49141,20940,96941,02641,07641,43541,37441,555
Female breast41,14441,87241,39441,51441,61940,95441,11640,82040,59840,58940,67640,99640,93141,150
Male breast384428415369379362375389371437400439443405
Female genital system25,88126,41126,83827,09127,01127,04927,25927,84827,73927,81327,81728,77029,02729,405
Cervix4,2044,2004,0923,9523,9193,8503,9243,9764,0214,0083,9093,9394,0924,074
Corpus and uterus, NOS6,4686,5856,7836,8536,8996,9907,0967,3847,4567,6757,7138,4028,6418,911
Corpus3,1213,1393,1853,1873,2613,2723,2593,4493,3773,4363,3333,6443,7143,812
Uterus, NOS3,3473,4463,5983,6663,6383,7183,8373,9354,0794,2394,3804,7584,9275,099
Ovary13,62714,06014,41414,68214,65714,71614,78714,85714,62114,36214,43614,57214,34614,404
Vagina403405382378391416382396376417398423428429
Vulva7627527657947758068098628659219469421,0221,034
Other female genital organs417409402432370271261373400430415492498553
Male genital system32,34931,67531,30031,08430,17629,62729,51429,02229,70329,12028,74429,27628,63027,955
Prostate31,72831,07830,71930,44629,55429,00228,90528,37229,09328,47128,08828,56027,97027,244
Testis378338335393344357359358326358376399380386
Penis202217205209250231217245246246234258239273
Other male genital organs4142413628373347384546594152
Urinary system23,66624,34424,91025,44325,42225,92826,40426,64927,31927,68227,94128,72629,31729,594
Urinary bladder 11,91012,00212,22512,62712,48313,03013,25313,47413,84314,03614,20114,73015,01415,245
Kidney and renal pelvis11,11611,73612,07812,16512,28612,31312,51712,37912,70312,89512,99513,21913,55913,518
Ureter345302294297323334347361340354371350338378
Other urinary organs295304313354330251287435433397374427406453
Eye and orbit227236226240231208252219249262278283280279
Brain and other nervous system12,76512,65512,60912,83012,90112,82913,15212,88613,23413,72414,17614,16414,49115,276
Endocrine system2,1462,2102,2992,2312,1552,2722,3542,4042,4882,5552,6342,6412,6892,660
Thyroid1,2411,3281,3541,3671,3121,4091,4621,5181,5621,6491,7071,6861,7471,690
Other endocrine including thymus905882945864843863892886926906927955942970
Lymphomas24,20524,01623,62823,26222,82222,21422,14521,92021,79921,53921,63921,52521,48521,518
Hodgkin lymphoma1,4031,2871,3231,3521,3471,2761,2721,3271,2711,1711,2501,2311,1681,130
Non-Hodgkin lymphoma22,80222,72922,30521,91021,47520,93820,87320,59320,52820,36820,38920,29420,31720,388
Myeloma10,50810,63910,71410,91310,80910,57810,75810,71210,87210,60610,69011,02211,41111,821
Leukemias21,07121,39721,53221,58121,60821,47221,71622,01621,92822,43122,68822,67323,19423,309
Acute lymphocytic leukemia1,3611,3951,4331,4321,4291,3711,4601,3931,4181,4241,4231,4361,4321,408
Chronic lymphocytic leukemia4,4764,3234,3864,4434,4764,3424,3914,4984,4714,3954,5574,4864,6084,598
Acute myeloid leukemia6,9327,4137,7497,9148,1268,2148,2678,5398,5688,9629,2239,1509,4919,484
Chronic myeloid leukemia1,7881,8021,6491,3671,2331,1641,0671,0779841,0001,0031,0191,0911,017
Other leukemias6,5146,4646,3156,4256,3446,3816,5316,5096,4876,6506,4826,5826,5726,802
Mesothelioma2,3432,3842,3712,4302,4762,5042,5532,4522,4322,5382,6062,5742,6512,686
Miscellaneous44,40141,17640,51941,14440,72340,07040,53440,14039,92039,70039,92639,88640,00240,276

Abbreviation: NOS = not otherwise specified.
*Data are from the National Vital Statistics System (NVSS). Data for deaths cover 100% of the U.S. population. Use caution when comparing numbers of cases and deaths because of potential differences in population coverage. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

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Return to your place in the textTABLE 15. Age-adjusted rate* of invasive cancer cases, by primary cancer site and year — United States, 1999–2012§
Cancer site19992000200120022003200420052006200720082009201020112012
All cancer sites combined 483.9485.1487.2483.7473.1471.6470.9473.4476.5471.8466.0453.2450.9433.7
Oral cavity and pharynx10.910.810.810.810.810.810.710.811.111.311.211.211.411.2
Lip1.00.90.90.90.80.70.70.70.70.60.60.60.60.5
Tongue2.62.72.72.82.82.92.93.03.13.33.33.23.43.4
Salivary gland1.21.21.21.21.21.21.21.31.31.31.31.21.21.3
Floor of mouth0.80.80.80.80.70.70.60.70.60.60.60.60.60.5
Gum and other mouth1.71.61.61.61.61.61.51.51.61.61.51.61.61.5
Nasopharynx0.60.60.50.60.60.60.60.50.60.60.50.50.50.5
Tonsil1.41.41.41.51.61.61.61.71.71.82.01.92.02.0
Oropharynx0.40.40.40.40.50.50.50.50.50.50.50.50.50.5
Hypopharynx0.90.80.80.80.80.80.70.70.70.70.70.60.60.6
Other oral cavity and pharynx0.40.40.40.30.30.30.30.20.30.30.20.30.30.3
Digestive system91.891.691.290.189.788.787.386.385.684.882.980.780.178.4
Esophagus5.05.05.04.95.05.15.05.04.95.04.94.64.64.5
Stomach7.67.57.47.37.37.27.06.86.86.76.66.86.76.6
Small intestine1.71.71.81.81.92.02.02.12.12.22.22.32.32.3
Colon and rectum56.456.055.153.852.651.049.648.146.945.743.441.340.438.8
Colon excluding rectum41.140.940.439.438.537.336.035.034.133.231.329.729.027.7
Rectum and rectosigmoid junction15.215.114.814.414.113.813.613.112.812.512.111.611.411.1
Anus, anal canal, and anorectum1.41.41.41.41.51.61.61.61.71.71.81.71.81.8
Liver and Intrahepatic bile duct4.95.25.25.45.65.96.16.36.87.07.47.47.67.8
Gallbladder1.21.21.21.11.21.11.21.21.11.11.21.21.11.1
Other biliary1.31.41.61.71.71.71.71.71.71.71.81.81.81.7
Pancreas11.111.211.311.211.511.611.812.012.012.312.212.312.412.4
Retroperitoneum0.40.40.40.40.40.40.40.40.40.40.40.40.40.4
Peritoneum, omentum, and mesentery0.40.50.50.60.60.70.60.60.70.70.60.60.60.6
Other digestive organs0.30.30.40.40.40.40.40.40.40.40.40.40.50.5
Respiratory system76.375.675.474.974.773.974.073.172.171.369.967.565.864.0
Nose, nasal cavity, and middle ear0.70.70.70.70.70.70.70.70.70.70.70.70.70.7
Larynx4.64.54.44.14.14.14.03.93.93.83.73.63.53.3
Lung and bronchus70.770.170.169.969.768.869.168.267.366.665.362.961.559.8
Pleura00000000000000
Trachea, mediastinum, and other respiratory organs0.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Bones and joints1.00.91.01.01.01.01.01.01.00.91.00.90.90.9
Soft tissue including heart2.93.03.03.03.13.23.33.23.33.33.33.33.23.2
Skin excluding basal and squamous16.617.718.719.118.919.821.020.721.121.621.921.521.921.7
Melanoma of the skin15.316.217.217.617.418.219.419.119.519.920.219.820.220.1
Other nonepithelial skin1.31.41.51.51.51.51.61.61.61.71.71.61.61.6
Male and female breast 74.372.772.370.666.966.165.766.066.767.267.665.366.365.7
Female breast135.2132.8132.3129.3122.9121.5121.0121.9123.2124.4125.3121.2123.2122.3
Male breast1.41.31.21.31.31.31.31.31.31.41.31.41.31.3
Female genital system51.951.651.450.449.048.949.149.149.349.649.949.049.148.9
Cervix9.79.69.18.78.48.28.28.18.17.98.07.67.57.4
Corpus and uterus, NOS24.223.824.324.023.223.824.024.224.524.925.425.425.725.8
Corpus23.423.123.623.322.523.023.323.423.824.124.624.624.925.0
Uterus, NOS0.80.80.80.80.80.70.70.70.70.80.80.80.80.8
Ovary14.314.414.213.813.613.213.113.012.712.712.211.811.611.3
Vagina0.70.80.70.70.70.70.60.70.70.70.70.70.70.7
Vulva2.42.32.42.42.42.32.42.42.52.52.52.52.52.6
Other female genital organs0.60.70.70.70.70.70.70.70.80.90.91.01.11.2
Male genital system176.5178.4180.6178.4163.7159.7156.4166.0170.1157.0148.7139.2137.5111.7
Prostate170.0171.9174.1172.0157.1153.1149.7159.5163.4150.1142.0132.5130.9105.1
Testis5.35.45.45.35.55.55.65.55.55.75.65.65.55.5
Penis0.90.90.90.90.90.80.80.80.90.90.80.80.90.8
Other male genital organs0.20.30.20.20.20.20.20.20.20.30.20.20.20.2
Urinary system35.235.736.136.637.137.838.238.138.538.738.437.537.437.1
Urinary bladder 22.022.121.922.022.022.222.221.521.721.521.320.920.720.4
Kidney and renal pelvis12.312.713.313.714.314.715.215.716.016.216.215.815.815.9
Ureter0.60.60.60.60.60.60.60.60.60.60.60.60.60.6
Other urinary organs0.30.30.30.20.30.30.30.30.30.30.30.30.30.3
Eye and orbit0.90.90.90.80.90.90.90.90.90.90.90.80.80.8
Brain and other nervous system6.96.96.86.96.86.96.96.86.86.86.86.66.56.4
Brain6.46.46.36.46.36.46.46.46.46.46.36.26.16.0
Cranial nerves other nervous system0.50.50.50.50.50.50.50.40.50.50.50.40.40.4
Endocrine system7.58.18.69.29.610.411.211.812.713.714.314.514.715.2
Thyroid6.87.47.98.58.99.610.511.111.912.913.613.714.014.5
Other endocrine including thymus0.70.70.70.70.70.80.80.80.80.80.70.80.70.7
Lymphomas22.222.122.222.422.622.922.922.622.622.722.622.421.821.3
Hodgkin lymphoma2.82.92.82.92.82.92.92.92.92.92.82.82.72.6
Non-Hodgkin lymphoma19.319.219.419.519.820.119.919.719.819.719.819.519.018.6
Myeloma5.65.85.95.95.96.06.05.95.96.16.26.36.36.3
Leukemias12.913.413.513.113.413.413.313.413.213.213.213.613.513.3
Acute lymphocytic leukemia1.41.51.51.51.51.61.51.61.61.61.61.61.71.6
Chronic lymphocytic leukemia4.14.54.64.64.74.84.84.84.64.64.54.44.44.3
Acute myeloid leukemia3.73.93.93.73.83.73.63.73.63.73.74.14.14.1
Chronic myeloid leukemia1.61.71.71.51.61.61.61.61.61.61.71.81.71.7
Other leukemias1.91.91.91.81.81.71.71.71.81.71.71.81.71.6
Mesothelioma1.11.11.11.11.11.11.11.11.01.01.01.01.01.0
Kaposi Sarcoma0.50.50.50.50.50.50.50.50.50.40.40.40.40.4
Miscellaneous12.612.412.111.811.210.910.710.510.310.19.89.99.69.4

Abbreviation: NOS = not otherwise specified.
*Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.
§Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Return to your place in the textFIGURE 4. Age-adjusted rate* of invasive cancer cases by primary cancer site, race,§ and sex — United States, 1999–2012
	This figure presents 11 line charts showing, by race and sex, the age-adjusted rate per 100,000 persons of invasive cancer cases in the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by race for male prostate cancer and female breast cancer.

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Rates are not presented for persons of unknown or other race. Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Return to your place in the textFIGURE 5. Age-adjusted rate* of invasive cancer cases, by primary cancer site, ethnicity,§ and sex — United States, 1999–2012
	This figure presents 11 line charts showing, by ethnicity (Hispanic and non-Hispanic) and sex, the age-adjusted rate per 100,000 population of invasive cancer cases in the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by ethnicity for male prostate cancer and female breast cancer.

* Rates are the number of cases per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Invasive cancer excludes basal and squamous cell carcinomas of the skin except when these occur on the skin of the genital organs, and in situ cancers except urinary bladder. Urinary bladder cancer includes invasive and in situ.

§ Data for specified ethnical populations should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

Data are compiled from cancer registries that meet the data quality criteria for all invasive cancer sites combined for all years, 1999–2012 (covering approximately 92% of the U.S. population). See registry-specific data quality information for all years, 1999–2012 (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=RegistriesPubCriteria). Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Return to your place in the textTABLE 16. Age-adjusted rate* of cancer deaths, by primary cancer site and year — United States, 1999–2012
Cancer site19992000200120022003200420052006200720082009201020112012
All cancer sites combined 200.7198.8196.3194.4190.9186.8185.2182.0179.3176.3173.4171.8168.7166.4
Oral cavity and pharynx2.72.72.72.72.62.62.52.52.52.52.42.52.52.5
Lip00000000000000
Tongue0.60.60.60.70.60.60.60.60.60.60.60.60.60.6
Salivary gland0.20.20.20.30.20.20.20.20.20.20.20.20.20.2
Floor of mouth0.10.100.10000000000
Gum and other mouth0.40.40.40.40.40.40.40.40.40.40.30.40.40.4
Nasopharynx0.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Tonsil0.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Oropharynx0.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Hypopharynx0.10.10.10.10.10.10.10.10.10.10.10.10.10.1
Other oral cavity and pharynx0.50.60.60.50.60.50.50.50.50.50.40.40.50.4
Digestive system47.547.346.746.245.644.544.143.843.343.042.342.341.841.6
Esophagus4.34.44.44.44.44.44.44.44.34.24.24.34.24.1
Stomach4.64.54.44.34.24.03.83.73.63.53.43.43.33.2
Small intestine0.40.40.40.40.40.40.40.40.30.40.40.40.40.4
Colon and rectum20.920.720.219.819.118.117.617.316.916.515.815.515.114.7
Colon excluding rectum17.917.617.116.816.215.214.714.414.113.613.012.612.312.0
Rectum and rectosigmoid junction3.03.03.03.02.92.92.92.92.82.92.82.92.82.7
Anus, anal canal, and anorectum0.20.20.20.20.20.20.20.20.20.20.20.20.20.3
Liver and intrahepatic bile duct4.54.64.74.95.05.15.35.35.45.65.85.96.16.3
Gallbladder0.80.70.70.70.70.70.70.70.60.60.60.60.60.6
Other biliary0.60.60.60.50.50.50.50.50.50.40.40.50.40.4
Pancreas10.610.510.610.610.510.710.810.910.811.010.811.010.911.0
Retroperitoneum0.10.10.10.10.10.10.10.10.10.10.10.10.10.1
Peritoneum, omentum, and mesentery0.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Other digestive organs0.40.30.30.30.30.20.20.30.30.30.30.30.30.3
Respiratory system57.157.557.056.655.854.854.353.252.151.049.748.747.346.2
Nose, nasal cavity, and middle ear0.20.20.20.20.20.20.20.10.20.20.20.10.10.1
Larynx1.41.41.31.31.31.21.21.21.11.21.11.11.11.0
Lung and bronchus55.455.855.355.054.253.452.951.750.749.648.447.446.045.0
Pleura00000000000000
Trachea, mediastinum, and other respiratory organs0.10.10.10.10.10.10.10.10.10.10.10.10.10.1
Bones and joints0.40.40.50.40.40.40.50.40.40.40.40.40.40.4
Soft tissue including heart1.31.31.31.21.21.31.31.31.31.31.31.31.31.3
Skin excluding basal and squamous3.53.53.53.43.53.53.63.63.63.53.73.63.63.6
Melanoma of the skin2.62.72.72.62.72.72.82.72.72.72.82.72.72.7
Other nonepithelial skin0.80.80.90.80.80.80.80.80.90.80.90.90.90.9
Male and female breast 15.215.214.814.514.313.813.613.212.912.712.412.312.011.8
Female breast26.626.626.025.625.324.524.123.623.022.622.221.921.521.3
Male breast0.30.40.40.30.30.30.30.30.30.30.30.30.30.3
Female genital system16.716.716.816.716.416.216.016.115.815.515.215.515.315.2
Cervix2.82.82.72.62.52.42.42.42.42.42.32.32.32.3
Corpus and uterus, NOS4.14.14.24.24.14.14.14.24.24.24.24.54.54.5
Corpus2.02.02.01.92.01.91.92.01.91.91.81.91.91.9
Uterus, NOS2.12.12.22.22.22.22.22.22.32.32.42.52.62.6
Ovary8.88.99.09.08.98.88.78.68.38.07.97.87.57.4
Vagina0.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Vulva0.50.40.50.50.40.50.50.50.50.50.50.50.50.5
Other female genital organs0.30.30.30.30.20.20.20.20.20.20.20.30.30.3
Male genital system32.130.930.029.227.726.725.824.724.723.522.622.321.220.0
Prostate31.630.429.528.727.226.225.424.224.223.022.121.820.819.6
Testis0.30.20.20.30.20.30.20.20.20.20.30.30.30.3
Penis0.20.20.20.20.20.20.20.20.20.20.20.20.20.2
Other male genital organs00000000000000
Urinary system8.78.88.88.98.78.88.88.78.78.68.58.68.68.5
Urinary bladder 4.44.34.34.44.34.44.44.44.44.44.44.44.44.4
Kidney and renal pelvis4.14.24.34.24.24.14.14.04.04.03.93.93.93.8
Ureter0.10.10.10.10.10.10.10.10.10.10.10.10.10.1
Other urinary organs0.10.10.10.10.10.10.10.10.10.10.10.10.10.1
Eye and orbit0.10.10.10.10.10.10.10.10.10.10.10.10.10.1
Brain and other nervous system4.64.54.44.54.44.34.34.24.24.34.34.24.34.4
Endocrine system0.80.80.80.80.70.80.80.80.80.80.80.80.80.8
Thyroid0.50.50.50.50.40.50.50.50.50.50.50.50.50.5
Other endocrine including thymus0.30.30.30.30.30.30.30.30.30.30.30.30.30.3
Lymphomas8.88.68.48.17.87.57.47.27.06.86.76.56.46.2
Hodgkin lymphoma0.50.50.50.50.50.40.40.40.40.40.40.40.40.3
Non-Hodgkin lymphoma8.38.27.97.77.47.16.96.76.66.46.36.16.05.9
Myeloma3.83.83.83.83.73.63.63.53.53.33.33.33.43.4
Leukemias7.77.77.67.57.47.37.37.27.17.17.16.96.96.8
Acute lymphocytic leukemia0.50.50.50.50.50.50.50.50.50.50.50.50.40.4
Chronic lymphocytic leukemia1.61.61.61.61.51.51.51.51.41.41.41.41.41.3
Acute myeloid leukemia2.52.72.72.82.82.82.82.82.82.82.92.82.82.8
Chronic myeloid leukemia0.70.60.60.50.40.40.40.40.30.30.30.30.30.3
Other leukemias2.42.32.22.22.22.22.22.12.12.12.02.02.02.0
Mesothelioma0.90.90.80.90.90.90.90.80.80.80.80.80.80.8
Miscellaneous16.214.814.414.414.013.513.413.012.712.412.211.911.711.5

Abbreviation: NOS = not otherwise specified.
*Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25-1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).
Data are from the National Vital Statistics System (NVSS). Data for deaths cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Return to your place in the textFIGURE 6. Age-adjusted rate* of cancer deaths, by primary cancer site, race, and sex — United States, 1999–2012§
	The figure presents 11 line charts showing, by race and sex, age-adjusted death rates per 100,000 population for the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by race for male prostate cancer and female breast cancer.

Abbreviations: AI/AN = American Indian/Alaska Native; A/PI = Asian/Pacific Islander.

* Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Rates are not presented for persons of unknown or other race. Data for specified racial populations other than white and black should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

§ Data are from the National Vital Statistics System (NVSS). Data for death rates cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Return to your place in the textFIGURE 7. Age-adjusted rate* of cancer deaths, by primary cancer site, ethnicity, and sex — United States, 1999–2012§
	The figure presents 11 line charts showing, by ethnicity (Hispanic and non-Hispanic) and sex, age-adjusted death rates per 100,000 population for the United States during 1999–2012. Rates are shown for males and females combined and separately for each sex for all cancer sites combined, colorectal cancer, and lung and bronchus cancer, and by ethnicity for male prostate cancer and female breast cancer.

* Rates are the number of deaths per 100,000 persons and are age-adjusted to the 2000 U.S. standard population (19 age groups – Census P25–1130). For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf).

Data for specified ethnic populations should be interpreted with caution. For more information, see USCS technical notes (http://www.cdc.gov/cancer/npcr/uscs/pdf/uscs-2012-technical-notes.pdf#nameddest=IntRaceEthnicityData).

§ Data are from the National Vital Statistics System (NVSS). Data for death rates cover 100% of the U.S. population. Caution should be used when comparing incidence and death rates because of potential differences in population coverage.

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Suggested citation for this article: Singh SD, Henley SJ, Ryerson AB. Surveillance for Cancer Incidence and Mortality — United States, 2012. MMWR Morb Mortal Wkly Rep 2016;63:17–58. DOI: http://dx.doi.org/10.15585/mmwr.mm6355a4.

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