Guidelines and Recommendations

Many HIV professional associations and government organizations, including CDC, have developed guidelines and recommendations for HIV screening, prevention, and treatment and care. Access a comprehensive collection of HIV clinical guidelines on’s Clinical Infoexternal icon website.

HIV Screening, Testing, and Diagnosis

Revised Recommendations for HIV Testing of Adults, Adolescents, and Pregnant Women in Health Care Settings: CDC’s revised recommendations provide guidance for HIV testing of adults, adolescents, and pregnant people in health care settings.

Final Recommendation Statement: HIV Screeningexternal icon: The US Preventive Services Task Force provides graded recommendations for HIV screening of pregnant people and adults and adolescents, as well as supporting evidence.

Screening for HIV in Health Care Settings: A Guidance Statement from the American College of Physicians and HIV Medicine Associationexternal icon
This guidance statement presents the available evidence for routine and repeat screening for HIV in health care settings.

HIV Prevention

Preventing New HIV Infections: This CDC website lists available guidelines and implementation resources for preventing HIV infection and linking patients to relevant prevention, medicaland social services. It also identifies which guidelines are current and which have been superseded or are outdated.

Preexposure Prophylaxis for the Prevention of HIV Infection in the United States—2021 Update—A Clinical Practice Guidelinepdf icon: CDC’s updated guideline provides comprehensive information about using pre-exposure prophylaxis (PrEP) to reduce the risk of acquiring HIV infection in adults and adolescents.

Preexposure Prophylaxis for the Prevention of HIV Infection in the United States—2021 Update—Clinical Providers’ Supplementpdf icon: This supplement to CDC’s Preexposure Prophylaxis for the Prevention of HIV Infection in the United States—2021 Update—A Clinical Practice Guideline provides additional information for health care providers who prescribe PrEP.

Updated Guidelines for Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV—United States, 2016pdf icon: CDC’s guidelines for using nonoccupational postexposure prophylaxis (nPEP) include information about current nPEP medications, testing recommendations, and transitioning patients between nPEP and PrEP.

HIV Treatment, Care, and Viral Suppression

Antiretroviral therapy (Art) for HIV Treatment

Recommendations for HIV Prevention with Adults and Adolescents with HIV in the United States, 2014: CDC has issued comprehensive recommendations for providing treatment and care for adults and adolescents with HIV and their sexual and drug injection partners.

Evidence of HIV Treatment and Viral Suppression in Preventing the Sexual Transmission of HIV: This web page from CDC covers the underlying evidence supporting HIV treatment as prevention and tips for effective treatment as prevention in practice.

Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIVexternal icon: These guidelines, developed by the US Department of Health and Human Services (HHS) Panel on Antiretroviral Guidelines for Adults and Adolescents, describe how to prescribe ART and manage adult and adolescent patients with HIV while they are taking ART.

Recommendations for the Use of Antiretroviral Drugs in Pregnant Women with HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United Statesexternal icon: These guidelines, developed by the HHS Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission, cover how to treat pregnant people with HIV and prevent perinatal HIV transmission.

Considerations for treating tuberculosis co-infection

Managing Drug Interactions in the Treatment of HIV-Related Tuberculosispdf icon: This guide from CDC explores the drug–drug interactions between rifamycin antibiotics and four classes of antiretroviral drugs.

Treatment of Drug-Susceptible Tuberculosisexternal icon: These guidelines offer guidance and recommendations for the treatment of drug-susceptible tuberculosis. The development of the guidelines was jointly sponsored by the American Thoracic Society, CDC, and the Infectious Diseases Society of America.