Reported Tuberculosis in the United States, 2021

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Table 31. Tuberculosis Cases and Clusters by Cluster Size:1 United States, 2019–2021

See Surveillance Slide #61.

Number and percentage of tuberculosis cases and clusters by cluster size.
Cluster size Clusters Cases2
No. (%)3 No. (%)4
Total 1,241 100.0 3,565 100.0
2 case cluster 836 (67.4) 1,672 (46.9)
3 case cluster 206 (16.6) 618 (17.3)
4 case cluster 95 (7.7) 380 (10.7)
5 case cluster 30 (2.4) 150 (4.2)
6 case cluster 18 (1.5) 108 (3.0)
7 case cluster 12 (1.0) 84 (2.4)
8 case cluster 11 (0.9) 88 (2.5)
9 case cluster 4 (0.3) 36 (1.0)
≥10 case cluster 29 (2.3) 429 (12.0)

1Clusters have two or more cases with matching spoligotype and 24-locus mycobacterial interspersed repetitive unit-variable number tandem repeat type (GENType) within a county during the specified 3-year time period.
2Cases with matching spoligotype and 24-locus mycobacterial interspersed repetitive unit-variable number tandem repeat type (GENType) are members of a cluster within a county during the specified 3-year time period.
3Denominator is total number of clusters.
4Denominator is total number of cases.