Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Biology - Life Cycle of D. repens

Life Cycle:

Life Cycle of D. repens

During a blood meal, an infected mosquito (Aedes, Anopheles, Culex, Mansonia) introduces third-stage filarial larvae of Dirofilaria repens onto the skin of the canine definitive host (but also occasionally humans, especially in Europe), where they penetrate into the bite wound The number 1 . In the definitive host, the L3 larvae undergo two more molts into L4 and adults, the latter of which resides in subcutaneous tissues The number 2 . Adult females are usually 100-170 mm long by 460-650 µm wide; males are usually 50-70 mm long by 370-450 µm wide. Adults can live for 5 – 10 years. In subcutaneous tissue, the female worms are capable of producing microfilariae over their lifespan. The microfilariae are found in peripheral blood The number 3 . A mosquito ingests the microfilariae during a blood meal The number 4 . After ingestion, the microfilariae migrate from the mosquito’s midgut through the hemocoel to the Malpighian tubules in the abdomen The number 5 . There the microfilariae develop into first-stage larvae The number 6 and subsequently into third-stage infective larvae The number 7 . The third-stage infective larvae migrate to the mosquito’s proboscis The number 8 and can infect another definitive host when it takes a blood meal The number 1 . In humans The number 9 , D. repens usually manifests as either a wandering worm in the subcutaneous tissue or a granulomatous nodule, although there are reports of pulmonary dirofilariasis with this species .

Life cycle image and information courtesy of DPDx.

TOP