CDC has released the 2022 CDC Clinical Practice Guideline for Prescribing Opioids for Pain, which updates and replaces the 2016 guideline. We are in the process of updating available resources and materials. Please refer to the 2022 Clinical Practice Guideline for current CDC recommendations and implementation strategies.

Data Resources

Analyzing Opioid Prescription Data and Oral Morphine Milligram Equivalents (MME)

More than 14,000 deaths in 2019 involved prescription opioids.

CDC’s National Center for Injury Prevention and Control has compiled a data file of opioid analgesic medications by National Drug Code (NDC) to help with analyzing population-level opioid prescription data. The data file is referred as Opioid NDC and Oral MME Conversion File. The file is intended solely for research, analytic purposes, population-based retrospective opioid utilization reviews, surveillance of population-level opioid utilization, and other population-level monitoring purposes.

The file contains opioid NDCs with their linked oral morphine milligram equivalent (MME) conversion factors. The following information is also provided at the NDC level: product name, generic name, form of drug, Drug Enforcement Administration Schedule, strength, and unit of measure for strength.

Requesting Access to the NDC and Oral MME Conversion File

To request access to the data file (Excel file, SAS file, reference SAS program), send an email to: All requests must include the following information:

  • Subject line: “Request: 2020 CDC Opioid NDC and Oral MME Conversion File”
  • Name
  • Intended use of the data file (100 words or less outlining the type of research or surveillance)
  • Name or type of your own prescription dataset (e.g. CMS prescription claims data, state PDMP data, etc.)
  • Company / Affiliation

You will receive a response to your request for access within 7-10 business days of submission.

Note: The Opioid NDC and Oral MME Conversion File is not intended to assist with clinical decision-making. For clinical guidance on dosage of opioids for treatment of pain, including MME conversion factors for commonly prescribed opioids, see our provider resources on calculating daily dose for commonly prescribed opioids and/or consult the FDA-approved product labeling.

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