Current Intelligence Bulletin 23: Ethylene Dibromide and Disulfiram Toxic Interaction

The purpose of this bulletin is to recommend that no worker be exposed to ethylene dibromide and disulfiram (Antabuse®, Ro-Sulfirarm®, tetraethylthiuram disulfide) and to summarize the current status of a NIOSH study. It provides other pertinent data, occupational health implications, and NIOSH recommendations for reducing the risk from the toxic interaction. This interim recommendation is based on preliminary results of NIOSH research currently in progress which suggests a serious toxic interaction between inhaled ethylene dibromide and ingested disulfiram resulting in exceedingly high mortality of laboratory rats.

Current Intelligence Bulletin 23: Ethylene Dibromide and Disulfiram Toxic Interaction