Articles about Spina Bifida

Publications

Key Findings

Key Findings: Study helps clinicians and families anticipate surgeries for individuals with spina bifida
In a study appearing in Pediatrics, CDC scientists and other researchers describe the lifetime occurrence of common surgeries and four key health outcomes in individuals with spina bifida.

Key Findings: Cost savings of spina bifida prevention after folic acid fortification in the United States
This study looked at potential cost savings associated with spina bifida prevention after folic acid fortification of enriched cereal grains in the United States.
(Published: January 11, 2016)

Key Findings: Sociodemographic Attributes and Spina Bifida Outcomes
Data from CDC’s spina bifida registry suggests certain patients may have less favorable health outcomes.
(Published: April 8, 2015)

Key Findings: Updated estimates of neural tube defects prevented by mandatory folic acid fortification – United States, 1995-2011
CDC’s Morbidity and Mortality Weekly Report published a new study looking at how many serious birth defects of the brain and spine, called neural tube defects (NTDs), have been prevented since the U.S. Food and Drug Administration required that all enriched grain products be fortified with folic acid.
(Published: January 15, 2015)

Feature Articles

Using Data to Help Babies Born with Spina Bifida
Learn how CDC is protecting babies born with spina bifida.
(Published: October 17, 2016)

Stories: Living with Spina Bifida
Spina bifida is a condition that affects the spine and is usually apparent at birth. It is a type of neural tube defect (NTD). To learn what it’s like to live with this condition or how families are affected, read these real stories from people living with spina bifida.

Scientific Articles

* These CDC-authored scientific articles are listed in order of date published, starting with the most recent.
**We have a separate webpage with a list of all published research from the National Spina Bifida Patient Registry.

Differences in length of stay and costs between comparable hospitalizations of patients with spina bifida with or without pressure injuries.
Archives of Physical Medicine and Rehabilitation 2019 Jan 23
Wang Y, Ouyang L, Dicianno BE, Beierwaltes P, Valdez R, Thibadeau J, Bolen J.
[Read Summaryexternal icon]

Skin ulcers and mortality among adolescents and young adults with spina bifida in South Carolina during 2000-2010.
Journal of Child Neurology  2016 Mar;31(3):370-7
Cai B, McDermott S, Wang Y, Royer JA, Mann JR, Hardin JW, Ozturk O, Ouyang L.
[Read full articleexternal icon]

Surgeries and Health Outcomes Among Patients With Spina Bifida.
Pediatrics 2018 September
Alabi NB, Thibadeau J, Wiener JS, Conklin MJ, Dias MS, Sawin KJ, Valdez R.
[Read Full Articleexternal icon]

Bladder Management and Continence Outcomes in Adults with Spina Bifida: Results from the National Spina Bifida Patient Registry, 2009 to 2015.
Journal of Urology 2018 July
Wiener JS, Suson KD, Castillo J, Routh JC, Tanaka ST, Liu T, Ward EA, Thibadeau JK, Joseph DB; National Spina Bifida Patient Registry.
[Read Summaryexternal icon]

Longitudinal Study of Bladder Continence in Patients with Spina Bifida in the National Spina Bifida Patient Registry.
Journal of Urology 2018 March
Liu T, Ouyang L, Thibadeau JK, Wiener JS, Routh JC, Castillo H, Castillo J, Freeman KA, Sawin KJ, Smith K, Van Speybroeck A, Valdez R.
[Read Summaryexternal icon]

Bladder Reconstruction Rates Differ among Centers Participating in National Spina Bifida Patient Registry.
Journal of Urology 2018 January
Routh JC, Joseph DB, Liu T, Schechter MS, Thibadeau JK, Wallis MC, Ward EA, Wiener JS.
[Read Summaryexternal icon]

Variation in Surgical Management of Neurogenic Bowel among Centers Participating in National Spina Bifida.
Journal of Pediatric Rehabilitation Medicine 2017 December

Routh JC, Joseph DB, Liu T, Schechter MS, Thibadeau JK, Wallis CM, Ward EA, Wiener JS.
[Read Summaryexternal icon]

Variation in Bowel and Bladder Continence across US Spina Bifida Programs: A Descriptive Study.
Journal of Pediatric Rehabilitation Medicine 2017 December
Freeman KA, Castillo H, Castillo J, Liu T, Schechter M, Wiener JS, Thibadeau JK, Ward E, Brei T.
[Read Summaryexternal icon]

Bowel Management and Continence in Adults with Spina Bifida: Results from the NSBPR 2009-2015.
Journal of Pediatric Rehabilitation Medicine 2017 December

Wiener JS, Suson KD, Castillo J, Routh JC, Tanaka S, Liu T, Ward E, Thibadeau JK, Joseph D, Registry NSBP.
[Read Summaryexternal icon]

Periconceptional maternal fever, folic acid intake, and the risk for neural tube defects.
Ann Epidemiol. 2017; 27(12):777-782e1.
Kerr SM, Parker SE, Mitchell AA, Tinker SC, Werler MM.
[Read full articleexternal icon]

Bladder Reconstruction Rates Differ Among Centers Participating in National Spina Bifida Patient Registry
Journal of Urology 2017 August 19
Routh JC, Joseph DB, Liu T, Schechter MS, Thibadeau JK, Wallis MC, Ward EA, Weiner JS
[Read Summaryexternal icon]

Design and Methodological Considerations of the National Spina Bifida Patient Registry Urologic and Renal Protocol for the Newborn and Young Child
Journal of Urology 2016 Jul 27.
Routh JC, Cheng EY, Austin JC, Baum MA, Gargollo PC, Grady RW, Herron AR, Kim SS, King SJ, Koh CJ, Paramsothy P, Raman L, Schechter MS, Smith KA, Tanaka ST, Thibadeau JK, Walker WO, Wallis MC, Wiener JS, Joseph DB.
[Read full articleexternal icon]

Factors associated with the timeliness of postnatal surgical repair of spina bifida
Child’s Nervous System 2016 May 14.
Radcliff E, Cassell CH, Laditka SB, Thibadeau JK, Correia J, Grosse SD, Kirby RS.
[Read full articleexternal icon]

When you click “Read summary”

The link will take you to a short summary of the article. The full article is available to subscribers of the publication's service.

Retrospective assessment of cost savings from prevention: folic acid fortification and spina bifida in the U.S.
Am Jl Prev Med. 2016 May;50 (5):S74-80.
Grosse SD, Berry RJ, Tilford JM, Kucik JE, Waitzman NJ.
[Read full articleexternal icon] [Read key findings]

Sociodemographic attributes and spina bifida outcomes
Pediatr. 2015;135(4):e957-e964.
Schechter MS, Liu T, Soe M, Swanson M, Ward E, Thibadeau J.
[Read full articleexternal icon] [Read key findings]

The national spina bifida patient registry: profile of a large cohort of participants from the first 10 clinics
J Pediatr. 2015 Feb; 166(2):444-50.e1.
Sawin K, Liu T, Ward E, Thibadeau J, Schechter M, Soe M, Walker W.
[Read full articleexternal icon]

Characteristics and survival of end stage renal disease (ESRD) patients with spina bifida in the United States Renal Data System (USRDS)
J Urol. 2015 Feb; 193(2):558-64.
Ouyang L, Bolen J, Valdez R, Joseph D, Baum MA, Thibadeau J.
[Read full articleexternal icon]

Updated estimates of neural tube defects prevented by mandatory folic acid fortification – United States, 1995-2011.
MMWR Morb Mortal Wkly Rep. 2015 Jan; 64(1):1-5
Williams J, Mai CT, Mulinare J, Isenburg J, Flood TJ, Ethen M, Frohnert B, Kirby RS.
[Read full article] [Read key findings]

Additional Selected Articles

Maternal use of weight loss products and the risk of neural tube defects in offspring: a systematic literature review.
Birth Defects Res. 2018; 110(1):48-55.
Hoang TT, Agopian AJ, Mitchell LE.
[Read full articleexternal icon]

Association of clomiphene and assisted reproductive technologies with the risk of neural tube defects.
Am J Epidemiol. 2016; 183(11):977-987.
Benedum CM, Yazdy MM, Parker SE, Mitchell AA, Werler MM.
[Read full articleexternal icon]

Supplement use and other characteristics among pregnant women with a previous pregnancy affected by a neural tube defect – United States, 1997-2009.
MMWR Morb Mortal Wkly Rep. 2015 Jan; 64(1):6-9
Arth A, Tinker S, Moore C, Canfield M, Agopian A, Reefhuis J.
[Read Full Article] [Read key findings]

Impact of periconceptional use of nitrosatable drugs on the risk of neural tube defects.
Am J Epidemiol. 2015; 182(8):675-84.
Benedum CM, Yazdy MM, Mitchell AA, Werler MM.
[Read full articleexternal icon]

A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele
The New England Journal of Medicine; 2011 March 17; 364:993-1004 Adzick NS, et al
[Read summaryexternal icon]