Updated Recommendations on the Use of Chlorhexidine-Impregnated Dressings for Prevention of Intravascular Catheter-Related Infections (2017)
Appendix: Table 5. Strength of Evidence for Using C-I Sponges under Standard Dressings vs. Using Standard Dressings or Gauze among Patients Aged < 18 Years with Short-term, Non-tunneled Central Venous Catheters F
Quantity and Type of Evidence
GRADE of Evidence for Outcome
(Limitations of the Evidence)
(Indirect, G Imprecise H)
|BSI without a source B||
(Indirect G, Imprecise J)
|Local catheter infection B||
|Product-related adverse events||
B A critical outcome
G Different skin antisepsis used for each study group.
H Wide confidence interval in one study, low power in second study.
I Underpowered; only 1 study.
J Only 1 study; wide confidence interval.
- Garland JS, Alex CP, Mueller CD, et al. A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates. Pediatrics. 2001;107(6):1431-1436.
- Duzkaya DS, Sahiner NC, Uysal G, Yakut T, Citak A. Chlorhexidine-Impregnated Dressings and Prevention of Catheter-Associated Bloodstream Infections in a Pediatric Intensive Care Unit. Crit Care Nurse. 2016;36(6):e1-e7.
- Levy I, Katz J, Solter E, et al. Chlorhexidine-impregnated dressing for prevention of colonization of central venous catheters in infants and children: a randomized controlled study. Pediatr Infect Dis J. 2005;24(8):676-679.
- Page last reviewed: December 14, 2017
- Page last updated: December 14, 2017
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