Post-Exposure Prophylaxis (PEP)

Photo of a patient examining medication with doctor

PEP is the use of antiretroviral drugs after a single high-risk event to stop HIV seroconversion. PEP must be started as soon as possible to be effective—and always within 72 hours of a possible exposure.

Resources for Consumers

Basic PEP Q&As – learn the basics about PEP and if it’s right for you.

PEP 101 Consumer Info Sheet (English and Spanish) [PDF – 706 KB]

Resources for Providers

HIV Nexus: Post-Exposure Prophylaxis

Visit the Non-Occupational Post-Exposure Prophylaxis (nPEP) Toolkit from the AETC National Coordinating Resource Center

PEP Consultation Service for Clinicians

9 am to 8 pm EST, Monday through Friday, and 11 am to 8 pm EST on weekends and holidays.
For more information on the services offered through the PEPline, visit the National Clinicians Consultation Center.


Guidelines: Post-Exposure Prophylaxis (PEP)