Post-Exposure Prophylaxis (PEP)

New (September 17, 2018)

Guidance for Non-HIV-Specialized Providers Caring for Persons with HIV Who Have been Displaced by Disasters (such as a Hurricane)external icon

Update (May 23, 2018)

Interim Statement Regarding Potential Fetal Harm from Exposure to Dolutegravir – Implications for HIV Post-exposure Prophylaxis (PEP). Please see attached PDF pdf icon[PDF – 104 KB].

Photo of a patient examining medication with doctor

PEP is the use of antiretroviral drugs after a single high-risk event to stop HIV seroconversion. PEP must be started as soon as possible to be effective—and always within 72 hours of a possible exposure.

Resources for Consumers

Basic PEP Q&As – learn the basics about PEP and if it’s right for you.

PEP 101 Consumer Info Sheet (English and Spanish) pdf icon[PDF – 691 KB]

Resources for Providers

Visit the Prescribe HIV Prevention website to learn about using PrEP and PEP to reduce new HIV infections.

Visit the Non-Occupational Post-Exposure Prophylaxis (nPEP) Toolkit from the AETC National Coordinating Resource Centerexternal icon

PEP Consultation Service for Clinicians

1-888-448-4911
9 a.m. – 2 a.m. ET
For more information on the services offered through the PEPline, visit the National Clinicians Consultation Centerexternal icon.

Guidelines