Post-Exposure Prophylaxis (PEP)

PEP is the use of antiretroviral drugs after a single high-risk event to stop HIV seroconversion. PEP must be started as soon as possible to be effective—and always within 72 hours of a possible exposure.
Resources for Consumers
Basic PEP Q&As – learn the basics about PEP and if it’s right for you.
PEP 101 Consumer Info Sheet (English and Spanish) pdf icon[PDF – 706 KB]
Resources for Providers
HIV Nexus: Post-Exposure Prophylaxis
PEP Consultation Service for Clinicians
1-888-448-4911
9 a.m. – 2 a.m. ET
For more information on the services offered through the PEPline, visit the National Clinicians Consultation Centerexternal icon.
Guidelines
Page last reviewed: March 28, 2022