Incidence of Malignant Mesothelioma, 1999–2018

U.S. Cancer Statistics Data Briefs, No. 27
March 2022

Mesothelioma is a rare cancer—2,875 cases were reported in the United States in 2018. Exposure to asbestos causes most cases of mesothelioma.

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Mesothelioma is a cancer that forms in the mesothelium, the thin tissue that lines many internal organs. A diagnosis of mesothelioma is based on histology codes. These include International Classification of Diseases for Oncology, Third Edition (ICD-O-3) histology codes—

  • 9050 (mesothelioma).
  • 9051 (fibrous mesothelioma).
  • 9052 (epithelioid mesothelioma).
  • 9053 (mesothelioma, biphasic).
  • 9055 (multicystic mesothelioma).

Mesothelioma is also defined by the part of the body it is found in, using ICD-O-3 anatomic site codes. The most common kind of mesothelioma forms in the tissue around the lungs, called the pleura (ICD-O-3 anatomic site code C38.4). Mesothelioma may also form in—

  • the tissue in the abdomen (peritoneum; C48.0–C48.8).
  • the tissue around the heart (pericardium; C38.0).
  • the tissue around the testicles (tunica vaginalis; C63.7).
Table 1. Number and Percentage of New Malignant Mesothelioma Cases1 by Sex and Type, United States,2 1999–2018
Subsite (ICD-O-3 anatomic code) Male Female Total
Count Percentage Count Percentage Count Percentage
All cases 48,073 100.0% 14,477 100.0% 62,550 100.0%
Pleura (C38.4) 40,824 84.9% 10,514 72.6% 51,338 82.1%
Peritoneum (C48.0-C48.8) 3,463 7.2% 2,706 18.7% 6,169 9.9%
Pericardium (C38.0) 62 0.1% 49 0.3% 111 0.2%
Tunica vaginalis (C63.7) 114 0.2% 0 0.0% 114 0.2%
Other3 3,610 7.5% 1,208 8.3% 4,818 7.7%

1Based on cases with ICD-O-3 histology codes 9050, 9051, 9052, 9053, or 9055. 94% of cases were based on microscopic confirmation.

2Based on 47 registries that met high-quality data criteria for all years 1999–2018, covering 97% of the U.S. population.

3Includes all other anatomic sites. The most common were lung and bronchus (C34.0–C34.9; 66% of “other” cases); unknown primary site (C80.9; 14%); overlapping lesion of heart, mediastinum and pleura (C38.8; 2%); and testis, not otherwise specified (C62.9; 2%). Other sites made up less than 2% of “other” cases.

Asbestos was used in many consumer products, automobile parts, and building materials in the 20th century, before scientists learned about its dangers to health. The potential for asbestos exposure in the United States peaked in the 1970s but has since declined as U.S. asbestos mines were closed and asbestos-containing products and materials were withdrawn from the market. The decline in asbestos exposure is reflected by declines in mesothelioma rates. However, people can still be exposed to asbestos. Although asbestos is no longer mined in the United States, it is imported from other countries to make some products. It is also still present in some older homes and buildings.

Data Source

Data in this brief come from U.S. Cancer Statistics, the official federal cancer statistics.

U.S. Cancer Statistics incidence data are from population-based registries that participate in CDC’s National Program of Cancer Registries (NPCR) and/or the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program and met high-quality data criteria during 1999–2018 for the 2020 data submission period, covering 97% of the U.S. population.

Suggested Citation

Centers for Disease Control and Prevention. Incidence of Malignant Mesothelioma, 1999–2018. USCS Data Brief, no. 27. Atlanta, GA: Centers for Disease Control and Prevention, US Department of Health and Human Services; 2022.

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