Untargeted metabolomics yields insight into ALS disease mechanisms.

Key points

Investigate metabolomic pathways associated with the development and treatment of ALS

Affiliates

Stephen A Goutman [1], Jonathan Boss [2], Kai Guo [3], Fadhl M Alakwaa [1], Adam Patterson [1], Sehee Kim [2], Masha Georges Savelieff [1], Junguk Hur [3], Eva L Feldman [1]

  1. Department of Neurology, University of Michigan
  2. Department of Biostatistics, University of Michigan
  3. Department of Biomedical Sciences, University of North Dakota

Journal

Neuromuscular

Summary

Understanding dysregulated metabolic pathways in amyotrophic lateral sclerosis (ALS) is important in discovering important therapeutic targets. This study located important metabolic pathway alterations with known pathomechanisms, or pathways to developing said disease, to ALS.

Link to paper

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Agency for Toxic Substances and Disease Registry