Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis

At a glance

Comparison of incidence of ALS in 45 geographical areas worldwide

Affiliates

Benoît Marin1,2,3,4,5,6, Farid Boumdiene1,2,3, Giancarlo Logroscino5,6, Philippe Couratier1,2,7, Marie-Claude Babron8,9, Anne Louise Leutenegger8,9, Massimilano Copetti10, Pierre-Marie Preux1,2,3, and Ettore Beghi4

  1. INSERM, U1094, Tropical Neuroepidemiology
  2. Univ. Limoges, UMR_S 1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology
  3. CHU Limoges, Centre d'Epide´miologie de Biostatistique et de Me´ thodologie de la Recherche
  4. Laboratorio di Malattie Neurologiche, IRCCS Istituto di Ricerche Farmacologiche Mario Negri
  5. Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari 'Aldo Moro'
  6. Unit of Neurodegenerative Diseases, University of Bari 'Aldo Moro', at 'Pia Fondazione Cardinale G. Panico'
  7. CHU Limoges, Service de Neurologie
  8. INSERM UMR 946, Genetic Variability and Human Diseases
  9. University Paris Diderot, UMR 946
  10. Unit of Biostatistics, IRCCS 'Casa Sollievo della Sofferenza'

Journal

International Journal of Epidemiology

Summary

To estimate the overall pooled worldwide crude ALS incidence, 44 studies were selected, covering 45 geographical areas in 11 sub-continents. Differences in ALS incidence rate estimates were identified between North Europe and East Asia or South Asia. However, incidence rates were similar for those in Europe, North America, and New Zealand. This review confirms a heterogeneous distribution worldwide of ALS and sets the scene to sustain a collaborative study involving a wide international consortium to investigate the link between ancestry, environment, and ALS incidence.

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