Association between cardiometabolic diseases and the risk and progression of motor neuron diseases in Sweden: a population-based case–control study

Affiliates

Charilaos Chourpiliadis [1], Anikó Lovik [1][2], Christina Seitz [1], Yihan Hu [1], Jing Wu [1], Petter Ljungman [1][3], Rayomand Press [4][5], Kristin Samuelsson [4][5], Caroline Ingre [4][5], Fang Fang [1]

1. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
2. Institute of Psychology, Leiden University, Leiden, the Netherlands
3. Department of Cardiology and Clinical Physiology, Danderyd Hospital, Stockholm, Sweden
4. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
5. Department of Neurology, Karolinska University Hospital, Stockholm, Sweden

Journal

The Lancet Regional Health – Europe

Summary

This research paper investigates the relationship between cardiometabolic diseases (CMDs) and motor neuron diseases (MNDs), including amyotrophic lateral sclerosis (ALS). The study found that most CMDs showed no association with the risk of MNDs, and in fact some, like type 2 diabetes and hypercholesterolemia were actually associated with lower risks of MNDs. However, CMDs were found to be associated with worse disease prognosis after a MND diagnosis. The study emphasizes the importance of monitoring the cardiometabolic health of patients who are diagnosed with MND

Link to Paper

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