Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

Biology - Life Cycle of D. tenuis

Life Cycle:

Life cycle of D. tenuis

During a blood meal, an infected mosquito (Aedes, Anopheles, and possibly others) introduces third-stage filarial larvae of Dirofilaria tenuis onto the skin of the raccoon definitive host (but also occasionally humans), where they penetrate into the bite wound The number 1. In the definitive host, the L3 larvae undergo two more molts into L4 and adults, the latter of which resides in subcutaneous tissues The number 2. Adult females are usually 80-130 mm long by 260-360 µm wide; males are usually 40-50 mm long by 190-260 µm wide. Adults can live for 5 - 10 years. In subcutaneous tissue, the female worms are capable of producing microfilariae over their lifespan. The microfilariae are found in peripheral blood The number 3. A mosquito ingests the microfilariae during a blood meal The number 4. After ingestion, the microfilariae migrate from the mosquito’s midgut through the hemocoel to the Malpighian tubules in the abdomen The number 5. There the microfilariae develop into first-stage larvae The number 6 and subsequently into third-stage infective larvae The number 7. The third-stage infective larvae migrate to the mosquito's proboscis The number 8 and can infect another definitive host when it takes a blood meal The number 1. In humans The number 9, D. tenuis may wander in the subcutaneous tissues for months, but finally is encapsulated in a granulomatous nodule, but may also be found around the eye or on the conjunctiva. Because of this, the infection in humans was first known as Dirofilaria conjunctivae.

Life cycle image and information courtesy of DPDx.

 
Contact Us:
  • Centers for Disease Control and Prevention
    1600 Clifton Rd.
    Atlanta, GA 30333
  • 1-800-CDC-INFO
    (1-800-232-4636)
    TTY: 1-888-232-6348
    Hours of Operation
    8am-8pm EST/ Monday-Friday
    Closed Holidays
  • Contact CDC-INFO
  • Page last reviewed: February 8, 2012
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC-INFO