The National Institute for Occupational Safety and Health, Centers for
Disease Control and Prevention (NIOSH, CDC) is conducting a peer review
of the NIOSH document entitled Current Intelligence Bulletin: Evaluation of Health Hazard and Recommendations for Occupational Exposure to Titanium Dioxide. This document has been
determined by NIOSH to be a Highly Influential Scientific Assessment according
to Office of Management and Budget (OMB) guidelines under the Federal Data
Quality Act 2000 (Public Law 106-554, Section 1(a)(3)). The overall
goal of the peer review is to enhance the quality and credibility of Agency
recommendations by ensuring that the scientific and technical work underlying
these recommendations receives appropriate review by independent scientific
and technical experts. The peer review charge was developed in accordance
with OMB guidelines, is consistent with NIOSH peer review practice, and
is meant to ensure that credible and appropriate science is used in the
development of its worker protection recommendations for titanium dioxide
exposure in the workplace.
Charge to the Peer Reviewers
The goals of this document are to (1) describe the relevant animal,
human and in vitro studies on the health effects of titanium dioxide
(TiO2), (2) provide a quantitative risk assessment based on dose-response
information from the rat and human lung dosimetry modeling, and (3) describe
the rationale NIOSH used in the development of the draft recommended
exposure limits (RELs). The charge to the Peer Reviewers is to objectively
review the document to determine whether
- the hazard identification is a reasonable reflection of the available
- the risk assessment and dosimetric modeling represents a reasonable
methodology for estimating worker risks from exposure to TiO2, and
- the data and analysis used by NIOSH were appropriate for the scientific
conclusions that formed the basis of the proposed RELs.
To facilitate review of this Current Intelligence Bulletin, the five
questions below should be considered:
- Is the hazard identification and discussion of health effects for
TiO2 a full and reasonable reflection of the human and animal studies
in the scientific literature?
- Are the risk assessment and dosimetric modeling methods used in this
document appropriate and relevant?
- Are the sampling and analysis methods adequate to characterize worker
exposure to fine and ultrafine TiO2?
- Is the use of particle surface area as a dose metric appropriate
for estimating worker risks from inhalation of TiO2?
- Are there additional relevant studies or methods that NIOSH should
consider in developing its RELs for TiO2?
The Peer Reviewers will be provided all substantive public comments
received in the NIOSH Docket Office by March 31, 2006. Upon request,
NIOSH will provide the Peer Reviewers with any statistical model not
described in the appendices to the document.
A public meeting will be held on February 27, 2006, from 9 a.m. to 4
p.m. at the Robert A. Taft Laboratory in Cincinnati, Ohio, as a forum
for scientists and representatives of government agencies, industry,
labor, and other stakeholders to discuss the document. The meeting
will be open to the public, limited only by the space available.
Time Frame for Review
We request that peer review comments be submitted to the NIOSH Docket
Office by April 30, 2006. Please return your written comments either
by mail (to Diane Miller, NIOSH Docket Office, Robert A. Taft Laboratories,
Mail Stop C-34, 4676 Columbia Parkway, Cincinnati, Ohio 45226) or electronically
via e-mail (to firstname.lastname@example.org.) All electronic comments should
be formatted as Microsoft Word. Please make reference to docket number
List of Reviewers
- Chao W. Chen, Ph.D.
National Center of Environmental Assessment
U.S. Environmental Protection Agency
- Mr. Harvey Clewell
Director, Center for Human Health Assessment
Centers for Health Research
Chemical Industry Institute for Toxicology (CIIT)
- Prof. Dr. med. Helmut Greim
Institute of Toxicology and Environmental Hygiene
Technical University of Munich
- Franklin E. Mirer, Ph.D., CIH
Director, Health and Safety Department
International Union - UAW
- Jonathan M. Samet, MD, MS
Chairman, Department of Epidemiology
Bloomberg School of Public Health
Johns Hopkins University
Page last modified: July 28, 2008
Page last reviewed: July 28, 2008
Content Source: National Institute for Occupational Safety and Health (NIOSH)