There is currently no treatment for CHHF. Supportive therapy is important for recovery from and survival of CHHF. This includes:
- maintenance of hydration
- management of shock (eg, fluid resuscitation, administration of vasopressin stocks)
- pain relief
- transfusions (when necessary)
Because CHHF is rare and there have only been two described outbreaks, the precise mortality and risk factors for mortality are unknown. In the first known outbreak, the only confirmed case was fatal. In the second outbreak in 2019, three out of five documented cases were fatal (case-fatality rate of 60%).
Patients who recover from infections with arenaviruses may continue to shed virus in blood, saliva, urine, or semen for months after they no longer have symptoms. For this reason, these fluids should be monitored for the presence of Chapare virus, since recovering patients have the potential to infect others (particularly sexual partners or other household members) via these fluids. Little is known about possible long-term complications or protective immunity following Chapare virus infection.